Data
Cognitive tests in clinical trials: 16,361 registered studies
Every study on ClinicalTrials.gov that names a cognitive test in an outcome measure: which tests trials use, for which conditions, how large the trials are and how that is changing, with a page for each condition and each test.
- Registered studies name a cognitive test in an outcome measure
- 16,361
The tests trials use most
The Trail Making Test is the cognitive test registered studies name most: 2,293 of 16,361, 14%. Next comes the Stroop Color-Word Test (1,929). As a primary outcome, the Stroop Color-Word Test leads, with 785 studies.
- 1
Trail Making Test2,293 studies, 709 as a primary outcome
- 2
Stroop Color-Word Test1,929 studies, 785 as a primary outcome
- 3
Verbal Learning1,832 studies, 711 as a primary outcome
- 4
Verbal Fluency1,745 studies, 640 as a primary outcome
- 5
Digit Span Test1,629 studies, 603 as a primary outcome
- 6
Symbol Coding1,457 studies, 451 as a primary outcome
- 7
N-Back Task790 studies, 381 as a primary outcome
- 8
Go/No-Go Task702 studies, 309 as a primary outcome
- 9
Continuous Performance Test638 studies, 265 as a primary outcome
- 10
Category Fluency623 studies, 232 as a primary outcome
- 11
Picture Naming Test466 studies, 201 as a primary outcome
- 12
Card Sorting Test (Berg)411 studies, 139 as a primary outcome
- 13
Psychomotor Vigilance Task395 studies, 154 as a primary outcome
- 14
Paced Visual Serial Addition Test337 studies, 140 as a primary outcome
- 15
Eriksen Flanker Task334 studies, 177 as a primary outcome
- 16
Task Switching Test334 studies, 132 as a primary outcome
- 17
Stop-Signal Task321 studies, 147 as a primary outcome
- 18
Short Story Recall315 studies, 129 as a primary outcome
- 19
Clock Drawing Task281 studies, 98 as a primary outcome
- 20
Complex Figure Copy and Recall276 studies, 107 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 12 | 5 |
| 2001 | 13 | 5 |
| 2002 | 36 | 20 |
| 2003 | 52 | 22 |
| 2004 | 63 | 29 |
| 2005 | 69 | 35 |
| 2006 | 91 | 36 |
| 2007 | 132 | 53 |
| 2008 | 159 | 68 |
| 2009 | 199 | 91 |
| 2010 | 235 | 101 |
| 2011 | 287 | 119 |
| 2012 | 324 | 148 |
| 2013 | 436 | 192 |
| 2014 | 542 | 211 |
| 2015 | 601 | 257 |
| 2016 | 720 | 295 |
| 2017 | 851 | 320 |
| 2018 | 893 | 369 |
| 2019 | 1,076 | 482 |
| 2020 | 938 | 398 |
| 2021 | 1,269 | 561 |
| 2022 | 1,276 | 512 |
| 2023 | 1,410 | 581 |
| 2024 | 1,524 | 661 |
| 2025 | 1,591 | 620 |
| 2026 | 1,442 | 562 |
Not shown: 23 studies that started before 2000 and 91 planned to start after 2026.
Explore the studies
11,688 studies match. 5,264 name a library test in a primary outcome. Median size 60 participants. Median time to the primary outcome: 8 weeks.
Loading 11,688 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 15 that started before 2000, 68 planned to start after 2026 and 6 with no start year.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 8 | 3 |
| 2001 | 10 | 4 |
| 2002 | 31 | 18 |
| 2003 | 41 | 20 |
| 2004 | 51 | 24 |
| 2005 | 61 | 30 |
| 2006 | 76 | 31 |
| 2007 | 106 | 46 |
| 2008 | 123 | 57 |
| 2009 | 164 | 75 |
| 2010 | 196 | 93 |
| 2011 | 239 | 104 |
| 2012 | 253 | 134 |
| 2013 | 346 | 171 |
| 2014 | 412 | 184 |
| 2015 | 463 | 211 |
| 2016 | 559 | 245 |
| 2017 | 637 | 260 |
| 2018 | 662 | 304 |
| 2019 | 794 | 384 |
| 2020 | 595 | 283 |
| 2021 | 902 | 444 |
| 2022 | 890 | 386 |
| 2023 | 979 | 430 |
| 2024 | 1,009 | 458 |
| 2025 | 1,034 | 425 |
| 2026 | 958 | 402 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 1,111, NIH 68, other 10,509. Interventional 10,190, observational 1,498.
As a primary outcomeSecondary or other outcome
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07908147 | Start2027 | PhaseEarly phase 1 | ConditionsCancer | Participants12 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07907718 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants50 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07906847 | Start2026 | PhaseObservational | ConditionsPain and fatigue | Participants80 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07905430 | Start2026 | PhaseNot applicable | ConditionsOther conditions | Participants152 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07904325 | Start2026 | PhaseObservational | ConditionsCardiovascular disease, Lung disease | Participants100 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07903896 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD | Participants75 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07902206 | Start2026 | PhaseNot applicable | ConditionsAging, frailty and exercise, Huntington's disease | Participants88 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07902076 | Start2027 | PhaseObservational | ConditionsAnxiety, PTSD and OCD | Participants280 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07900893 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants10,000 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07900451 | Start2026 | PhaseObservational | ConditionsADHD | Participants90 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07900048 | Start2026 | PhaseNot applicable | ConditionsADHD | Participants100 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07899827 | Start2027 | PhaseNot applicable | ConditionsCancer, Substance use and addiction | Participants50 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07899671 | Start2026 | PhaseNot applicable | ConditionsOther conditions | Participants160 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07899528 | Start2026 | PhaseNot applicable | ConditionsOther conditions | Participants112 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07899242 | Start2025 | PhaseNot applicable | ConditionsOther conditions | Participants242 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07898722 | Start2025 | PhaseNot applicable | ConditionsAnxiety, PTSD and OCD, Pain and fatigue | Participants40 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07898371 | Start2026 | PhaseObservational | ConditionsMultiple sclerosis | Participants3,000 | Lead sponsorIndustry | StatusRecruiting | Library tests named
|
| NCT07897474 | Start2026 | PhaseObservational | ConditionsSleep and sleep disorders | Participants100 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07897214 | Start2026 | PhaseNot applicable | ConditionsOther conditions | Participants15 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07897175 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants54 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07897084 | Start2026 | PhaseNot applicable | ConditionsOther conditions | Participants120 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07895979 | Start2026 | PhaseNot applicable | ConditionsCognitive impairment and decline | Participants216 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07895797 | Start2026 | PhaseNot applicable | ConditionsBrain injury and concussion | Participants38 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07895407 | Start2025 | PhasePhase 4 | ConditionsDelirium, surgery and intensive care | Participants148 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07894965 | Start2026 | PhaseNot applicable | ConditionsPain and fatigue | Participants90 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
Tests by condition
Cells show
Registered studies in the condition group that name the test in an outcome measure.
- None
- 1 to 9
- 10 to 24
- 25 to 49
- 50 to 99
- 100 or more
| Test | Dementia and Alzheimer's1,673 studies in all | Aging, frailty and exercise1,398 studies in all | Depression and bipolar disorder1,247 studies in all | Stroke1,233 studies in all | Substance use and addiction895 studies in all | Parkinson's disease892 studies in all | Mild cognitive impairment859 studies in all | Cancer760 studies in all | Sleep and sleep disorders749 studies in all | Anxiety, PTSD and OCD692 studies in all | Cardiovascular disease682 studies in all | Pain and fatigue681 studies in all | Healthy volunteers656 studies in all | Schizophrenia and psychosis640 studies in all | Obesity and diabetes627 studies in all | Delirium, surgery and intensive care619 studies in all | Multiple sclerosis612 studies in all | Brain injury and concussion444 studies in all | ADHD357 studies in all | Cognitive impairment and decline354 studies in all | Hearing loss247 studies in all | COVID-19 and long COVID221 studies in all | Autism200 studies in all | Epilepsy138 studies in all | Lung disease110 studies in all |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trail Making Test2,293 studies | 273 | 255 | 204 | 156 | 52 | 156 | 213 | 187 | 85 | 69 | 105 | 94 | 68 | 102 | 102 | 69 | 43 | 115 | 24 | 77 | 17 | 36 | 17 | 15 | 18 |
| Stroop Color-Word Test1,929 studies | 116 | 230 | 138 | 105 | 75 | 126 | 126 | 65 | 89 | 79 | 81 | 114 | 98 | 46 | 103 | 37 | 56 | 59 | 61 | 47 | 8 | 30 | 19 | 12 | 18 |
| Verbal Learning1,832 studies | 224 | 128 | 178 | 63 | 77 | 61 | 183 | 235 | 66 | 70 | 64 | 72 | 56 | 112 | 74 | 51 | 139 | 111 | 8 | 79 | 5 | 22 | 5 | 25 | 9 |
| Verbal Fluency1,745 studies | 248 | 136 | 154 | 110 | 29 | 140 | 177 | 200 | 58 | 61 | 61 | 53 | 39 | 107 | 63 | 46 | 58 | 86 | 12 | 63 | 3 | 24 | 14 | 17 | 13 |
| Digit Span Test1,629 studies | 181 | 129 | 143 | 100 | 48 | 86 | 169 | 107 | 63 | 72 | 59 | 61 | 64 | 66 | 64 | 44 | 25 | 98 | 58 | 60 | 14 | 31 | 8 | 15 | 7 |
| Symbol Coding1,457 studies | 117 | 116 | 143 | 61 | 60 | 41 | 84 | 58 | 89 | 31 | 46 | 82 | 56 | 43 | 59 | 29 | 375 | 43 | 9 | 40 | 7 | 21 | 1 | 7 | 4 |
| N-Back Task790 studies | 44 | 68 | 79 | 22 | 68 | 13 | 42 | 19 | 51 | 31 | 20 | 31 | 51 | 66 | 33 | 5 | 6 | 26 | 30 | 16 | 3 | 4 | 5 | 3 | 3 |
| Go/No-Go Task702 studies | 20 | 41 | 79 | 12 | 80 | 18 | 16 | 10 | 44 | 63 | 12 | 22 | 42 | 15 | 44 | 4 | 10 | 12 | 65 | 7 | 2 | 2 | 17 | 5 | 0 |
| Continuous Performance Test638 studies | 14 | 22 | 73 | 16 | 53 | 7 | 17 | 35 | 37 | 37 | 5 | 27 | 18 | 78 | 15 | 4 | 6 | 39 | 123 | 14 | 0 | 9 | 17 | 10 | 1 |
| Category Fluency623 studies | 167 | 48 | 41 | 33 | 6 | 44 | 92 | 26 | 15 | 12 | 30 | 16 | 11 | 46 | 27 | 13 | 10 | 22 | 4 | 22 | 4 | 14 | 3 | 3 | 1 |
| Picture Naming Test466 studies | 104 | 23 | 19 | 99 | 2 | 37 | 71 | 14 | 8 | 6 | 14 | 2 | 5 | 7 | 14 | 10 | 2 | 15 | 0 | 23 | 3 | 6 | 3 | 8 | 0 |
| Card Sorting Test (Berg)411 studies | 12 | 23 | 65 | 13 | 27 | 23 | 15 | 10 | 21 | 29 | 10 | 11 | 18 | 50 | 11 | 2 | 3 | 17 | 15 | 8 | 1 | 1 | 17 | 5 | 1 |
| Psychomotor Vigilance Task395 studies | 7 | 13 | 18 | 4 | 20 | 10 | 7 | 5 | 237 | 12 | 10 | 35 | 31 | 1 | 16 | 5 | 2 | 4 | 2 | 2 | 0 | 3 | 0 | 5 | 10 |
| Paced Visual Serial Addition Test337 studies | 5 | 9 | 17 | 6 | 30 | 6 | 4 | 15 | 20 | 13 | 3 | 28 | 10 | 13 | 7 | 3 | 169 | 18 | 2 | 3 | 0 | 1 | 1 | 2 | 3 |
| Eriksen Flanker Task334 studies | 12 | 45 | 33 | 5 | 15 | 10 | 3 | 7 | 18 | 22 | 6 | 12 | 30 | 3 | 25 | 1 | 4 | 10 | 18 | 6 | 2 | 1 | 12 | 1 | 1 |
| Task Switching Test334 studies | 31 | 37 | 20 | 16 | 7 | 14 | 22 | 16 | 21 | 12 | 13 | 13 | 16 | 14 | 13 | 3 | 3 | 18 | 5 | 7 | 7 | 4 | 7 | 0 | 1 |
| Stop-Signal Task321 studies | 5 | 7 | 19 | 1 | 92 | 10 | 2 | 4 | 14 | 29 | 6 | 9 | 10 | 5 | 24 | 0 | 0 | 4 | 49 | 1 | 0 | 1 | 9 | 1 | 2 |
| Short Story Recall315 studies | 91 | 32 | 27 | 12 | 3 | 11 | 74 | 14 | 4 | 11 | 3 | 3 | 7 | 19 | 16 | 9 | 2 | 10 | 1 | 10 | 4 | 4 | 0 | 3 | 0 |
| Clock Drawing Task281 studies | 69 | 35 | 11 | 19 | 4 | 33 | 41 | 11 | 5 | 4 | 20 | 6 | 4 | 2 | 11 | 20 | 2 | 0 | 0 | 21 | 1 | 3 | 0 | 1 | 2 |
| Complex Figure Copy and Recall276 studies | 53 | 10 | 17 | 15 | 3 | 21 | 31 | 8 | 4 | 8 | 9 | 6 | 5 | 12 | 12 | 7 | 4 | 15 | 1 | 14 | 2 | 8 | 1 | 10 | 1 |
| Matrix Reasoning272 studies | 25 | 20 | 21 | 11 | 1 | 14 | 13 | 4 | 11 | 10 | 5 | 9 | 16 | 21 | 19 | 1 | 3 | 10 | 9 | 8 | 4 | 3 | 14 | 4 | 0 |
| Choice Reaction Time270 studies | 25 | 23 | 36 | 4 | 9 | 15 | 5 | 6 | 17 | 8 | 4 | 13 | 20 | 5 | 13 | 2 | 3 | 4 | 7 | 5 | 0 | 3 | 1 | 6 | 1 |
| Delay Discounting257 studies | 1 | 5 | 19 | 1 | 104 | 4 | 1 | 8 | 16 | 12 | 7 | 6 | 10 | 9 | 36 | 1 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cancellation Test253 studies | 42 | 9 | 15 | 75 | 2 | 3 | 5 | 5 | 5 | 7 | 3 | 5 | 8 | 6 | 6 | 0 | 1 | 17 | 5 | 3 | 1 | 2 | 1 | 1 | 0 |
| Tower Planning247 studies | 9 | 18 | 29 | 7 | 9 | 13 | 5 | 4 | 9 | 19 | 3 | 11 | 9 | 40 | 6 | 3 | 5 | 9 | 20 | 3 | 0 | 6 | 7 | 2 | 0 |
| Dimensional Change Card Sort214 studies | 13 | 37 | 12 | 10 | 7 | 1 | 9 | 6 | 10 | 12 | 12 | 2 | 12 | 0 | 18 | 2 | 2 | 9 | 6 | 9 | 1 | 2 | 13 | 5 | 1 |
| Simple Reaction Time210 studies | 13 | 14 | 19 | 5 | 7 | 14 | 4 | 2 | 15 | 13 | 2 | 22 | 20 | 1 | 4 | 1 | 5 | 15 | 1 | 3 | 0 | 7 | 0 | 4 | 0 |
| Paired Associate Learning204 studies | 34 | 14 | 12 | 6 | 15 | 5 | 11 | 6 | 18 | 9 | 2 | 14 | 30 | 11 | 12 | 1 | 2 | 5 | 1 | 7 | 0 | 4 | 2 | 2 | 3 |
| Rapid Visual Information Processing204 studies | 8 | 12 | 25 | 5 | 14 | 1 | 3 | 7 | 11 | 13 | 5 | 18 | 18 | 13 | 12 | 0 | 2 | 4 | 7 | 6 | 0 | 4 | 1 | 0 | 0 |
| Vocabulary Test199 studies | 5 | 9 | 7 | 7 | 4 | 1 | 3 | 9 | 4 | 4 | 9 | 2 | 7 | 4 | 8 | 0 | 1 | 8 | 1 | 6 | 9 | 0 | 21 | 9 | 0 |
Compare tests over time
The panel's testThe other tests chosenEvery panel has the same scale. 2026 is partly planned starts.
Show as a table
| Start year | Trail Making Test | Stroop Color-Word Test | Verbal Learning | Verbal Fluency |
|---|---|---|---|---|
| 2000 | 2 | 3 | 1 | 1 |
| 2001 | 0 | 3 | 5 | 1 |
| 2002 | 3 | 5 | 8 | 3 |
| 2003 | 8 | 2 | 14 | 4 |
| 2004 | 10 | 8 | 14 | 9 |
| 2005 | 14 | 11 | 17 | 19 |
| 2006 | 14 | 6 | 13 | 9 |
| 2007 | 21 | 13 | 22 | 22 |
| 2008 | 17 | 15 | 28 | 18 |
| 2009 | 29 | 16 | 28 | 29 |
| 2010 | 32 | 29 | 42 | 29 |
| 2011 | 47 | 31 | 33 | 36 |
| 2012 | 44 | 32 | 42 | 34 |
| 2013 | 60 | 42 | 53 | 58 |
| 2014 | 66 | 64 | 82 | 59 |
| 2015 | 85 | 67 | 91 | 79 |
| 2016 | 103 | 85 | 98 | 85 |
| 2017 | 122 | 79 | 107 | 93 |
| 2018 | 117 | 103 | 92 | 107 |
| 2019 | 155 | 119 | 122 | 121 |
| 2020 | 122 | 99 | 76 | 90 |
| 2021 | 172 | 151 | 137 | 131 |
| 2022 | 188 | 168 | 138 | 123 |
| 2023 | 228 | 198 | 157 | 147 |
| 2024 | 211 | 182 | 144 | 130 |
| 2025 | 210 | 198 | 132 | 167 |
| 2026 | 201 | 193 | 123 | 133 |
Rising and falling tests
Rising
| Test | 2016 to 2020 | 2021 to 2025 | Change |
|---|---|---|---|
| Attention Network Test | 0.7% | 1.1% | Up 50% |
| Dimensional Change Card Sort | 1.3% | 1.8% | Up 35% |
| Eriksen Flanker Task | 1.8% | 2.3% | Up 28% |
| Corsi Block-Tapping Test | 1.1% | 1.3% | Up 19% |
| Stroop Color-Word Test | 10.8% | 12.7% | Up 17% |
Falling
| Test | 2016 to 2020 | 2021 to 2025 | Change |
|---|---|---|---|
| Letter-Number Sequencing Task | 1.4% | 0.6% | Down 55% |
| Dot-Probe Task | 1.5% | 0.7% | Down 54% |
| Paced Visual Serial Addition Test | 2.4% | 1.3% | Down 48% |
| Arithmetic Fluency Task | 0.8% | 0.5% | Down 44% |
| Stop-Signal Task | 2.7% | 1.8% | Down 36% |
How many participants trials enroll
- Early phase 136 median, 20 to 71
- Phase 130 median, 17 to 57
- Phase 1/236 median, 18 to 60
- Phase 260 median, 32 to 120
- Phase 2/3100 median, 48 to 240
- Phase 3246 median, 83 to 669
- Phase 477 median, 36 to 159
- Not applicable60 median, 31 to 114
- Observational111 median, 57 to 300
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Early phase 1 | 217 | 36 | 20 to 71 |
| Phase 1 | 504 | 30 | 17 to 57 |
| Phase 1/2 | 285 | 36 | 18 to 60 |
| Phase 2 | 1,341 | 60 | 32 to 120 |
| Phase 2/3 | 155 | 100 | 48 to 240 |
| Phase 3 | 635 | 246 | 83 to 669 |
| Phase 4 | 671 | 77 | 36 to 159 |
| Not applicable | 9,682 | 60 | 31 to 114 |
| Observational | 2,559 | 111 | 57 to 300 |
When trials measure the cognitive outcome
Latest time point of each outcome
- Within a day3,923 outcomes, 1,915 as a primary outcome
- Up to 4 weeks4,276 outcomes, 1,730 as a primary outcome
- 1 to 3 months6,757 outcomes, 2,641 as a primary outcome
- 3 to 6 months3,981 outcomes, 1,350 as a primary outcome
- 6 to 12 months2,682 outcomes, 858 as a primary outcome
- 1 to 2 years1,241 outcomes, 428 as a primary outcome
- Over 2 years1,054 outcomes, 392 as a primary outcome
- No duration given1,679 outcomes, 799 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
23,914 of the 25,593 outcome measures give a duration. A single visit counts as within a day.
Median time to the primary outcome, by test
| Test | Primary outcomes | Median |
|---|---|---|
| Stroop Color-Word Test | 724 | 8 weeks |
| Verbal Learning | 665 | 13 weeks |
| Trail Making Test | 659 | 12 weeks |
| Verbal Fluency | 599 | 13 weeks |
| Digit Span Test | 570 | 12 weeks |
| Symbol Coding | 420 | 12 weeks |
| N-Back Task | 350 | 4 weeks |
| Go/No-Go Task | 282 | 6 weeks |
| Continuous Performance Test | 248 | 8 weeks |
| Category Fluency | 218 | 15 weeks |
What industry trials use
- 1
Symbol Coding273 studies, 60 as a primary outcome
- 2
Verbal Learning148 studies, 41 as a primary outcome
- 3
Verbal Fluency139 studies, 39 as a primary outcome
- 4
Trail Making Test141 studies, 33 as a primary outcome
- 5
Choice Reaction Time78 studies, 33 as a primary outcome
- 6
Digit Span Test102 studies, 31 as a primary outcome
- 7
Stroop Color-Word Test95 studies, 26 as a primary outcome
- 8
Continuous Performance Test54 studies, 21 as a primary outcome
- 9
Category Fluency76 studies, 20 as a primary outcome
- 10
Simple Reaction Time53 studies, 20 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Status, results, interventions and countries
Status
- Recruiting3,024 studies, 1,136 as a primary outcome
- Not yet recruiting1,048 studies, 408 as a primary outcome
- Active, not recruiting688 studies, 264 as a primary outcome
- Completed7,953 studies, 3,546 as a primary outcome
- Stopped early1,099 studies, 408 as a primary outcome
- Status unknown2,549 studies, 1,032 as a primary outcome
What they test
- Behavioral4,208 studies, 1,910 as a primary outcome
- Drug3,904 studies, 1,308 as a primary outcome
- Device2,887 studies, 1,162 as a primary outcome
- Dietary supplement889 studies, 428 as a primary outcome
- Procedure670 studies, 225 as a primary outcome
- Diagnostic test381 studies, 159 as a primary outcome
- Biological238 studies, 52 as a primary outcome
- Radiation191 studies, 60 as a primary outcome
- Combination product73 studies, 29 as a primary outcome
- Genetic43 studies, 17 as a primary outcome
- Other4,228 studies, 1,825 as a primary outcome
- None given1,117 studies, 539 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States5,548 studies, 2,549 as a primary outcome
- China1,348 studies, 450 as a primary outcome
- France1,058 studies, 299 as a primary outcome
- Canada1,028 studies, 312 as a primary outcome
- United Kingdom870 studies, 263 as a primary outcome
- Spain803 studies, 271 as a primary outcome
- Germany750 studies, 205 as a primary outcome
- Italy723 studies, 267 as a primary outcome
- Türkiye702 studies, 372 as a primary outcome
- Taiwan513 studies, 236 as a primary outcome
- Netherlands417 studies, 101 as a primary outcome
- Switzerland410 studies, 108 as a primary outcome
131 countries in all. A study with sites in several counts in each; 1,053 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed studies: 3,626 of 7,953, 46%
| Results | Completed studies |
|---|---|
| Results on ClinicalTrials.gov and a paper | 776, 10% |
| Results on ClinicalTrials.gov only | 1,139, 14% |
| A results paper only | 1,711, 22% |
| Neither | 4,327, 54% |
Every condition
- Dementia and Alzheimer's1,673 registered studies, 661 with a test as a primary outcome, median size 83Most used: Trail Making Test (273), Verbal Fluency (248), Verbal Learning (224)
- Aging, frailty and exercise1,398 registered studies, 580 with a test as a primary outcome, median size 78Most used: Trail Making Test (255), Stroop Color-Word Test (230), Verbal Fluency (136)
- Depression and bipolar disorder1,247 registered studies, 464 with a test as a primary outcome, median size 74Most used: Trail Making Test (204), Verbal Learning (178), Verbal Fluency (154)
- Stroke1,233 registered studies, 397 with a test as a primary outcome, median size 60Most used: Trail Making Test (156), Verbal Fluency (110), Stroop Color-Word Test (105)
- Substance use and addiction895 registered studies, 411 with a test as a primary outcome, median size 60Most used: Cue Reactivity Task (158), Delay Discounting (104), Stop-Signal Task (92)
- Parkinson's disease892 registered studies, 276 with a test as a primary outcome, median size 49Most used: Trail Making Test (156), Verbal Fluency (140), Stroop Color-Word Test (126)
- Mild cognitive impairment859 registered studies, 508 with a test as a primary outcome, median size 72Most used: Trail Making Test (213), Verbal Learning (183), Verbal Fluency (177)
- Cancer760 registered studies, 274 with a test as a primary outcome, median size 72Most used: Verbal Learning (235), Verbal Fluency (200), Trail Making Test (187)
- Sleep and sleep disorders749 registered studies, 264 with a test as a primary outcome, median size 64Most used: Psychomotor Vigilance Task (237), Stroop Color-Word Test (89), Symbol Coding (89)
- Anxiety, PTSD and OCD692 registered studies, 273 with a test as a primary outcome, median size 69Most used: Stroop Color-Word Test (79), Digit Span Test (72), Verbal Learning (70)
- Cardiovascular disease682 registered studies, 185 with a test as a primary outcome, median size 119Most used: Trail Making Test (105), Stroop Color-Word Test (81), Verbal Learning (64)
- Pain and fatigue681 registered studies, 237 with a test as a primary outcome, median size 60Most used: Stroop Color-Word Test (114), Trail Making Test (94), Symbol Coding (82)
- Healthy volunteers656 registered studies, 354 with a test as a primary outcome, median size 60Most used: Stroop Color-Word Test (98), Trail Making Test (68), Digit Span Test (64)
- Schizophrenia and psychosis640 registered studies, 273 with a test as a primary outcome, median size 60Most used: Verbal Learning (112), Verbal Fluency (107), Trail Making Test (102)
- Obesity and diabetes627 registered studies, 228 with a test as a primary outcome, median size 79Most used: Stroop Color-Word Test (103), Trail Making Test (102), Verbal Learning (74)
- Delirium, surgery and intensive care619 registered studies, 234 with a test as a primary outcome, median size 120Most used: Trail Making Test (69), Verbal Learning (51), Verbal Fluency (46)
- Multiple sclerosis612 registered studies, 197 with a test as a primary outcome, median size 61Most used: Symbol Coding (375), Paced Visual Serial Addition Test (169), Verbal Learning (139)
- Brain injury and concussion444 registered studies, 229 with a test as a primary outcome, median size 50Most used: Trail Making Test (115), Verbal Learning (111), Digit Span Test (98)
- ADHD357 registered studies, 185 with a test as a primary outcome, median size 63Most used: Continuous Performance Test (123), Go/No-Go Task (65), Stroop Color-Word Test (61)
- Cognitive impairment and decline354 registered studies, 230 with a test as a primary outcome, median size 75Most used: Verbal Learning (79), Trail Making Test (77), Verbal Fluency (63)
- Hearing loss247 registered studies, 133 with a test as a primary outcome, median size 44Most used: Trail Making Test (17), Digit Span Test (14), Spectral Ripple Task (9)
- COVID-19 and long COVID221 registered studies, 71 with a test as a primary outcome, median size 89Most used: Trail Making Test (36), Digit Span Test (31), Stroop Color-Word Test (30)
- Autism200 registered studies, 84 with a test as a primary outcome, median size 60Most used: Vocabulary Test (21), Emoji Emotion Recognition (19), Stroop Color-Word Test (19)
- Epilepsy138 registered studies, 57 with a test as a primary outcome, median size 55Most used: Verbal Learning (25), Verbal Fluency (17), Digit Span Test (15)
- Lung disease110 registered studies, 38 with a test as a primary outcome, median size 74Most used: Trail Making Test (18), Stroop Color-Word Test (18), Verbal Fluency (13)
Every test
- Trail Making Test2,293
- Stroop Color-Word Test1,929
- Verbal Learning1,832
- Verbal Fluency1,745
- Digit Span Test1,629
- Symbol Coding1,457
- N-Back Task790
- Go/No-Go Task702
- Continuous Performance Test638
- Category Fluency623
- Picture Naming Test466
- Card Sorting Test (Berg)411
- Psychomotor Vigilance Task395
- Paced Visual Serial Addition Test337
- Eriksen Flanker Task334
- Task Switching Test334
- Stop-Signal Task321
- Short Story Recall315
- Clock Drawing Task281
- Complex Figure Copy and Recall276
- Matrix Reasoning272
- Choice Reaction Time270
- Delay Discounting257
- Cancellation Test253
- Tower Planning247
- Dimensional Change Card Sort214
- Simple Reaction Time210
- Paired Associate Learning204
- Rapid Visual Information Processing204
- Vocabulary Test199
- AX Continuous Performance Test191
- Cue Reactivity Task188
- Emoji Emotion Recognition187
- Letter-Number Sequencing Task184
- Selective Reminding Task183
- Corsi Block-Tapping Test181
- Size Order Memory Test162
- Delayed Recall Module159
- Dot-Probe Task148
- Pattern and Letter Comparison147
- Finger Tapping Task144
- Picture Order Memory Test144
- Attention Network Test138
- Symbol Scan Task129
- Iowa Gambling Lite125
- Contrast Sensitivity Test119
- Implicit Association Test (IAT)113
- Monetary Incentive Delay106
- Balloon Risk105
- Arithmetic Fluency Task101
- Purchase Task89
- Oddball Target Detection86
- Sustained Attention to Response85
- Spatial Working Memory78
- Delayed Match-to-Sample69
- Line Angle Matching69
- Antisaccade Task68
- Line Bisection Test68
- Emotional Stroop Task66
- Hidden Path Learning66
- Probabilistic Reversal Learning66
- Mental Rotation64
- Mnemonic Similarity Task62
- Effort for Rewards Task61
- Emotion Regulation Task56
- Field of View Speed Test53
- Face-name Memory Task51
- One-Touch Tower Planning51
- Intra/Extra Dimensional Set Shift50
- Affective Go/No-Go48
- Word Pair Learning48
- Visual Search Test47
- Effort Discounting Task46
- Design Fluency Test45
- Recognition Memory Test45
- Pattern Recognition Memory41
- Probabilistic Reward Task38
- Sternberg Memory Scanning38
- Token Commands Task36
- Tower of Hanoi34
- Ball-Toss Game33
- Block Copy Test33
- Indirect Hints Task33
- Multi-Source Interference Task32
- Motor Sequence Task30
- Simon Task30
- Approach-Avoidance Task28
- Biological Motion Task28
- Serial Reaction Time27
- Trust Game26
- Betting Choice Task24
- Operation Span24
- Social Slips Stories Task24
- Mirror Tracing Task23
- Posner Cueing23
- Lexical Decision Task22
- Reading Span Task22
- Serial Naming Task22
- Sentence Completion Inhibition Test21
- Beads Task20
- Scrambled Sentences Test20
Questions, answered from the data
Which cognitive test do clinical trials use most?
The Trail Making Test: 2,293 of the 16,361 registered studies name it in an outcome measure, 14%. Next come the Stroop Color-Word Test (1,929) and Verbal Learning (1,832).
Which cognitive test do trials use most as a primary outcome?
The Stroop Color-Word Test, named in a primary outcome by 785 studies. 6,794 of the 16,361 studies, 42%, name a cognitive test in a primary outcome.
Which conditions have the most trials with a cognitive outcome?
Dementia and Alzheimer's, with 1,673 registered studies, then aging, frailty and exercise (1,398) and depression and bipolar disorder (1,247). 2,897 studies fall in none of the named groups.
How many participants does a phase 2 trial with a cognitive outcome enroll?
Half of the phase 2 studies enroll 60 participants or fewer, and the middle half enroll 32 to 120. 1,341 of them give a size. Phase 3 studies enroll a median of 246.
How long after the start do trials measure a cognitive outcome?
Half of the primary outcomes that name a library test are measured within 8 weeks of the start, and the middle half from 1 week to 6 months. 9,314 primary outcomes give a duration.
Where do trials with a cognitive outcome run?
In 131 countries. The United States has sites in 5,548 of the 16,361 studies, then China (1,348) and France (1,058). 1,053 studies list no site.
How many completed trials with a cognitive outcome have reported results?
3,626 of the 7,953 completed studies, 46%, have reported results: 1,915 posted them on ClinicalTrials.gov, 2,487 have a results paper linked to the registry record, and 776 did both. The other 4,327 show neither.
Which cognitive tests are new trials using more?
Of the studies that started in 2021 to 2025, the share that name the Attention Network Test is 50% larger than in 2016 to 2020. Dimensional Change Card Sort grew 35% and The Eriksen Flanker Task grew 28%. The Letter-Number Sequencing Task fell most, by 55%.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
More on use and evidence
- Test-retest evidence39 of 582 test families have 25 or more test-retest papersWhich tests have their reliability over time on record, and which well-used tests lack it.
- Reliability and validity evidence55 of 582 test families have 150 or more reliability or validity papersPapers on each test's reliability, validity and norms, set against how much it is used.
- Every test, every measure534 of 582 test families in the census are in the libraryThe full table, with grades, papers per year and a download.
Plan a trial's cognitive outcomes
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.