Clinical trials data
Cognitive tests in schizophrenia and psychosis trials: 640 registered studies
Every registered schizophrenia and psychosis study on ClinicalTrials.gov that names a cognitive test in an outcome measure: the tests used most, how often as a primary outcome, which tests go together, how large the studies are and when they measure the outcome.
- Registered schizophrenia and psychosis studies name a cognitive test in an outcome
- 640
- Led by industry
- 65
The tests schizophrenia and psychosis trials use most
Verbal Learning leads: 112 of the 640 studies name it, 18%. Next comes Verbal Fluency (107). As a primary outcome, Verbal Learning leads with 37 studies.
- 1
Verbal Learning112 studies, 37 as a primary outcome
- 2
Verbal Fluency107 studies, 34 as a primary outcome
- 3
Trail Making Test102 studies, 18 as a primary outcome
- 4
Continuous Performance Test78 studies, 28 as a primary outcome
- 5
N-Back Task66 studies, 32 as a primary outcome
- 6
Digit Span Test66 studies, 15 as a primary outcome
- 7
Emoji Emotion Recognition52 studies, 16 as a primary outcome
- 8
Card Sorting Test (Berg)50 studies, 15 as a primary outcome
- 9
Category Fluency46 studies, 13 as a primary outcome
- 10
Stroop Color-Word Test46 studies, 9 as a primary outcome
- 11
Symbol Coding43 studies, 9 as a primary outcome
- 12
Tower Planning40 studies, 12 as a primary outcome
- 13
AX Continuous Performance Test32 studies, 20 as a primary outcome
- 14
Letter-Number Sequencing Task29 studies, 8 as a primary outcome
- 15
Indirect Hints Task27 studies, 6 as a primary outcome
- 16
Matrix Reasoning21 studies, 6 as a primary outcome
- 17
Oddball Target Detection20 studies, 8 as a primary outcome
- 18
Short Story Recall19 studies, 3 as a primary outcome
- 19
Go/No-Go Task15 studies, 3 as a primary outcome
- 20
Task Switching Test14 studies, 1 as a primary outcome
- 21
Monetary Incentive Delay13 studies, 7 as a primary outcome
- 22
Rapid Visual Information Processing13 studies, 4 as a primary outcome
- 23
Paced Visual Serial Addition Test13 studies, 3 as a primary outcome
- 24
Beads Task12 studies, 4 as a primary outcome
- 25
Finger Tapping Task12 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
13% of schizophrenia and psychosis studies name only instruments outside the library, such as clinician-administered screening scales. They count in every figure on this page and are not listed. The explorer below holds all 114 tests.
Tests used together
- Trail Making Test and Verbal Learning43 studies name both
- Trail Making Test and Verbal Fluency30 studies name both
- Continuous Performance Test and Verbal Learning28 studies name both
- Category Fluency and Continuous Performance Test27 studies name both
- Digit Span Test and Trail Making Test27 studies name both
- AX Continuous Performance Test and Continuous Performance Test24 studies name both
- Verbal Fluency and Verbal Learning24 studies name both
- Category Fluency and Verbal Learning23 studies name both
- Digit Span Test and Verbal Learning23 studies name both
- Category Fluency and Trail Making Test21 studies name both
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 1 | 1 |
| 2001 | 1 | 0 |
| 2002 | 8 | 8 |
| 2003 | 9 | 6 |
| 2004 | 10 | 4 |
| 2005 | 10 | 5 |
| 2006 | 9 | 4 |
| 2007 | 18 | 10 |
| 2008 | 10 | 3 |
| 2009 | 13 | 8 |
| 2010 | 17 | 10 |
| 2011 | 19 | 4 |
| 2012 | 23 | 10 |
| 2013 | 29 | 14 |
| 2014 | 33 | 14 |
| 2015 | 28 | 13 |
| 2016 | 38 | 19 |
| 2017 | 26 | 10 |
| 2018 | 34 | 10 |
| 2019 | 44 | 20 |
| 2020 | 23 | 12 |
| 2021 | 36 | 18 |
| 2022 | 34 | 12 |
| 2023 | 35 | 13 |
| 2024 | 35 | 10 |
| 2025 | 42 | 15 |
| 2026 | 48 | 18 |
Phases and sponsors
By phase
- Early phase 112 studies, 7 as a primary outcome
- Phase 130 studies, 19 as a primary outcome
- Phase 1/29 studies, 2 as a primary outcome
- Phase 284 studies, 34 as a primary outcome
- Phase 2/311 studies, 2 as a primary outcome
- Phase 333 studies, 9 as a primary outcome
- Phase 452 studies, 24 as a primary outcome
- Not applicable366 studies, 156 as a primary outcome
- Observational43 studies, 20 as a primary outcome
Sponsors and study types
Lead sponsor: industry 65, NIH 2, universities, hospitals and others 573. Interventional 597, observational 43.
Status, results, interventions and countries
Status
- Recruiting108 studies, 35 as a primary outcome
- Not yet recruiting30 studies, 14 as a primary outcome
- Active, not recruiting22 studies, 9 as a primary outcome
- Completed350 studies, 166 as a primary outcome
- Stopped early50 studies, 15 as a primary outcome
- Status unknown80 studies, 34 as a primary outcome
What they test
- Behavioral179 studies, 86 as a primary outcome
- Drug248 studies, 109 as a primary outcome
- Device132 studies, 47 as a primary outcome
- Dietary supplement17 studies, 6 as a primary outcome
- Procedure10 studies, 2 as a primary outcome
- Diagnostic test5 studies, 2 as a primary outcome
- Biological3 studies, 0 as a primary outcome
- Combination product1 studies, 0 as a primary outcome
- Genetic1 studies, 1 as a primary outcome
- Other121 studies, 49 as a primary outcome
- None given21 studies, 11 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States253 studies, 139 as a primary outcome
- France50 studies, 15 as a primary outcome
- Canada45 studies, 15 as a primary outcome
- Taiwan44 studies, 18 as a primary outcome
- China40 studies, 6 as a primary outcome
- Germany34 studies, 7 as a primary outcome
- Spain34 studies, 13 as a primary outcome
- United Kingdom28 studies, 10 as a primary outcome
- Italy15 studies, 3 as a primary outcome
- Denmark14 studies, 1 as a primary outcome
- South Korea14 studies, 3 as a primary outcome
- India13 studies, 3 as a primary outcome
57 countries in all. A study with sites in several counts in each; 43 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed schizophrenia and psychosis studies: 196 of 350, 56%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed schizophrenia and psychosis studies | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 51, 15% | 776, 10% |
| Results on ClinicalTrials.gov only | 77, 22% | 1,139, 14% |
| A results paper only | 68, 19% | 1,711, 22% |
| Neither | 154, 44% | 4,327, 54% |
How many participants they enroll
- Early phase 146 median, 18 to 98
- Phase 131 median, 21 to 77
- Phase 257 median, 31 to 92
- Phase 3142 median, 49 to 400
- Phase 460 median, 40 to 98
- Not applicable60 median, 32 to 108
- Observational100 median, 62 to 289
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Early phase 1 | 12 | 46 | 18 to 98 |
| Phase 1 | 29 | 31 | 21 to 77 |
| Phase 2 | 82 | 57 | 31 to 92 |
| Phase 3 | 33 | 142 | 49 to 400 |
| Phase 4 | 51 | 60 | 40 to 98 |
| Not applicable | 362 | 60 | 32 to 108 |
| Observational | 43 | 100 | 62 to 289 |
When the cognitive outcome is measured
Latest time point of each outcome
- Within a day184 outcomes, 85 as a primary outcome
- Up to 4 weeks256 outcomes, 84 as a primary outcome
- 1 to 3 months390 outcomes, 134 as a primary outcome
- 3 to 6 months246 outcomes, 71 as a primary outcome
- 6 to 12 months101 outcomes, 12 as a primary outcome
- 1 to 2 years47 outcomes, 9 as a primary outcome
- Over 2 years22 outcomes, 5 as a primary outcome
- No duration given59 outcomes, 22 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
1,246 of the 1,305 outcome measures give a duration. A single visit counts as within a day.
Median time to the primary outcome, by test
| Test | Primary outcomes | Median |
|---|---|---|
| Verbal Learning | 35 | 8 weeks |
| Verbal Fluency | 33 | 9 weeks |
| N-Back Task | 30 | 4 weeks |
| Continuous Performance Test | 28 | 10 weeks |
| AX Continuous Performance Test | 18 | 3 weeks |
| Trail Making Test | 17 | 8 weeks |
| Emoji Emotion Recognition | 16 | 11 weeks |
| Digit Span Test | 15 | 10 weeks |
| Card Sorting Test (Berg) | 13 | 12 weeks |
| Category Fluency | 12 | 10 weeks |
Explore the schizophrenia and psychosis studies
558 studies match. 242 name a library test in a primary outcome. Median size 60 participants. Median time to the primary outcome: 8 weeks.
Loading 558 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 1 that started before 2000, 4 planned to start after 2026 and 1 with no start year.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 1 | 1 |
| 2001 | 1 | 0 |
| 2002 | 8 | 8 |
| 2003 | 8 | 5 |
| 2004 | 8 | 4 |
| 2005 | 10 | 5 |
| 2006 | 9 | 4 |
| 2007 | 18 | 10 |
| 2008 | 10 | 3 |
| 2009 | 13 | 8 |
| 2010 | 16 | 10 |
| 2011 | 17 | 4 |
| 2012 | 21 | 10 |
| 2013 | 26 | 13 |
| 2014 | 31 | 14 |
| 2015 | 24 | 12 |
| 2016 | 32 | 17 |
| 2017 | 23 | 10 |
| 2018 | 31 | 8 |
| 2019 | 39 | 17 |
| 2020 | 19 | 9 |
| 2021 | 32 | 15 |
| 2022 | 29 | 10 |
| 2023 | 24 | 8 |
| 2024 | 28 | 7 |
| 2025 | 29 | 11 |
| 2026 | 45 | 17 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 61, NIH 2, other 495. Interventional 523, observational 35.
As a primary outcomeSecondary or other outcome
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07900893 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants10,000 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07881016 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder, Autism | Participants3,000 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07875790 | Start2028 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants325 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07856381 | Start2026 | PhaseObservational | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants180 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07856368 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07853807 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants325 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07853079 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants88 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07834203 | Start2025 | PhaseObservational | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder | Participants500 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07806877 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants60 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07805980 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07795554 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants60 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07786714 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07748078 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Substance use and addiction | Participants140 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07747181 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants135 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07745140 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants66 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07743645 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants100 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07702526 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants160 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07701343 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07680959 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants100 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07659938 | Start2027 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants30 | Lead sponsorIndustry | StatusNot yet recruiting | Library tests named
|
| NCT07658898 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants74 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07647380 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants50 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07633899 | Start2022 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants32 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07621549 | Start2025 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants80 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07616999 | Start2026 | PhaseObservational | ConditionsSchizophrenia and psychosis | Participants178 | Lead sponsorOther | StatusRecruiting | Library tests named
|
Questions, answered from the data
Which cognitive test do schizophrenia and psychosis trials use most?
Verbal Learning: 112 of the 640 registered studies name it in an outcome measure, 18%. Next come Verbal Fluency (107) and the Trail Making Test (102).
Which cognitive test do schizophrenia and psychosis trials use most as a primary outcome?
Verbal Learning, named in a primary outcome by 37 studies. 273 of the 640 studies, 43%, name a cognitive test in a primary outcome.
How many participants does a phase 2 schizophrenia and psychosis trial enroll?
Half of the phase 2 schizophrenia and psychosis studies enroll 57 participants or fewer, and the middle half enroll 31 to 92. 82 of them give a size.
How long after the start do schizophrenia and psychosis trials measure a cognitive outcome?
Half of the primary outcomes that name a library test are measured within 8 weeks of the start, and the middle half from 1 week to 13 weeks. 400 primary outcomes give a duration.
Which cognitive tests do schizophrenia and psychosis trials use together?
The Trail Making Test with Verbal Learning most often: 43 studies name both. Next, the Trail Making Test with Verbal Fluency (30).
How many completed schizophrenia and psychosis trials have reported results?
196 of the 350 completed schizophrenia and psychosis studies, 56%, have reported results: 128 posted them on ClinicalTrials.gov, 119 have a results paper linked to the registry record, and 51 did both. The other 154 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Plan the cognitive outcomes of a schizophrenia and psychosis trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.