Clinical trials data
Cognitive tests in COVID-19 and long COVID trials: 221 registered studies
Every registered COVID-19 and long COVID study on ClinicalTrials.gov that names a cognitive test in an outcome measure: the tests used most, how often as a primary outcome, which tests go together, how large the studies are and when they measure the outcome.
- Registered COVID-19 and long COVID studies name a cognitive test in an outcome
- 221
- Led by industry
- 13
The tests COVID-19 and long COVID trials use most
The Trail Making Test leads: 36 of the 221 studies name it, 16%. Next comes the Digit Span Test (31). As a primary outcome, the Trail Making Test leads with 15 studies.
- 1
Trail Making Test36 studies, 15 as a primary outcome
- 2
Digit Span Test31 studies, 14 as a primary outcome
- 3
Stroop Color-Word Test30 studies, 13 as a primary outcome
- 4
Verbal Fluency24 studies, 8 as a primary outcome
- 5
Verbal Learning22 studies, 8 as a primary outcome
- 6
Symbol Coding21 studies, 5 as a primary outcome
- 7
Category Fluency14 studies, 5 as a primary outcome
- 8
Continuous Performance Test9 studies, 2 as a primary outcome
- 9
Complex Figure Copy and Recall8 studies, 4 as a primary outcome
- 10
Simple Reaction Time7 studies, 2 as a primary outcome
- 11
Picture Naming Test6 studies, 4 as a primary outcome
- 12
Tower Planning6 studies, 1 as a primary outcome
- 13
Short Story Recall4 studies, 3 as a primary outcome
- 14
N-Back Task4 studies, 2 as a primary outcome
- 15
Paired Associate Learning4 studies, 1 as a primary outcome
- 16
Rapid Visual Information Processing4 studies, 1 as a primary outcome
- 17
Task Switching Test4 studies, 1 as a primary outcome
- 18
Matrix Reasoning3 studies, 2 as a primary outcome
- 19
Psychomotor Vigilance Task3 studies, 2 as a primary outcome
- 20
Size Order Memory Test3 studies, 2 as a primary outcome
- 21
Clock Drawing Task3 studies, 1 as a primary outcome
- 22
Effort Discounting Task3 studies, 1 as a primary outcome
- 23
Choice Reaction Time3 studies, 0 as a primary outcome
- 24
Recognition Memory Test3 studies, 0 as a primary outcome
- 25
Word Pair Learning2 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
50% of COVID-19 and long COVID studies name only instruments outside the library, such as clinician-administered screening scales. They count in every figure on this page and are not listed. The explorer below holds all 58 tests.
Tests used together
- Stroop Color-Word Test and Trail Making Test18 studies name both
- Digit Span Test and Trail Making Test17 studies name both
- Trail Making Test and Verbal Learning13 studies name both
- Digit Span Test and Stroop Color-Word Test12 studies name both
- Digit Span Test and Verbal Learning12 studies name both
- Stroop Color-Word Test and Verbal Fluency11 studies name both
- Digit Span Test and Verbal Fluency10 studies name both
- Stroop Color-Word Test and Verbal Learning10 studies name both
- Trail Making Test and Verbal Fluency10 studies name both
- Category Fluency and Digit Span Test9 studies name both
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 0 | 0 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 0 | 0 |
| 2011 | 0 | 0 |
| 2012 | 0 | 0 |
| 2013 | 0 | 0 |
| 2014 | 0 | 0 |
| 2015 | 0 | 0 |
| 2016 | 0 | 0 |
| 2017 | 0 | 0 |
| 2018 | 2 | 0 |
| 2019 | 0 | 0 |
| 2020 | 41 | 16 |
| 2021 | 46 | 16 |
| 2022 | 31 | 12 |
| 2023 | 52 | 12 |
| 2024 | 20 | 3 |
| 2025 | 18 | 6 |
| 2026 | 11 | 6 |
Phases and sponsors
By phase
- Early phase 12 studies, 0 as a primary outcome
- Phase 13 studies, 1 as a primary outcome
- Phase 1/23 studies, 2 as a primary outcome
- Phase 225 studies, 4 as a primary outcome
- Phase 2/34 studies, 0 as a primary outcome
- Phase 35 studies, 1 as a primary outcome
- Phase 44 studies, 1 as a primary outcome
- Not applicable97 studies, 29 as a primary outcome
- Observational78 studies, 33 as a primary outcome
Sponsors and study types
Lead sponsor: industry 13, NIH 1, universities, hospitals and others 207. Interventional 143, observational 78.
Status, results, interventions and countries
Status
- Recruiting34 studies, 11 as a primary outcome
- Not yet recruiting8 studies, 2 as a primary outcome
- Active, not recruiting15 studies, 2 as a primary outcome
- Completed110 studies, 33 as a primary outcome
- Stopped early13 studies, 3 as a primary outcome
- Status unknown41 studies, 20 as a primary outcome
What they test
- Behavioral43 studies, 12 as a primary outcome
- Drug39 studies, 10 as a primary outcome
- Device37 studies, 16 as a primary outcome
- Dietary supplement10 studies, 3 as a primary outcome
- Procedure8 studies, 1 as a primary outcome
- Diagnostic test7 studies, 3 as a primary outcome
- Biological8 studies, 4 as a primary outcome
- Combination product1 studies, 0 as a primary outcome
- Genetic1 studies, 0 as a primary outcome
- Other63 studies, 13 as a primary outcome
- None given32 studies, 16 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States61 studies, 16 as a primary outcome
- Germany16 studies, 3 as a primary outcome
- Spain16 studies, 5 as a primary outcome
- Canada12 studies, 4 as a primary outcome
- France12 studies, 2 as a primary outcome
- United Kingdom11 studies, 2 as a primary outcome
- Italy8 studies, 3 as a primary outcome
- Sweden7 studies, 3 as a primary outcome
- Türkiye7 studies, 4 as a primary outcome
- Chile6 studies, 1 as a primary outcome
- China6 studies, 3 as a primary outcome
- Switzerland6 studies, 2 as a primary outcome
36 countries in all. A study with sites in several counts in each; 8 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed COVID-19 and long COVID studies: 40 of 110, 36%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed COVID-19 and long COVID studies | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 8, 7% | 776, 10% |
| Results on ClinicalTrials.gov only | 6, 5% | 1,139, 14% |
| A results paper only | 26, 24% | 1,711, 22% |
| Neither | 70, 64% | 4,327, 54% |
How many participants they enroll
- Phase 288 median, 40 to 142
- Not applicable60 median, 38 to 104
- Observational194 median, 65 to 400
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Phase 2 | 24 | 88 | 40 to 142 |
| Not applicable | 96 | 60 | 38 to 104 |
| Observational | 77 | 194 | 65 to 400 |
When the cognitive outcome is measured
Latest time point of each outcome
- Within a day22 outcomes, 8 as a primary outcome
- Up to 4 weeks35 outcomes, 14 as a primary outcome
- 1 to 3 months125 outcomes, 39 as a primary outcome
- 3 to 6 months49 outcomes, 19 as a primary outcome
- 6 to 12 months47 outcomes, 30 as a primary outcome
- 1 to 2 years2 outcomes, 0 as a primary outcome
- Over 2 years8 outcomes, 0 as a primary outcome
- No duration given6 outcomes, 1 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
288 of the 294 outcome measures give a duration. A single visit counts as within a day.
Median time to the primary outcome, by test
| Test | Primary outcomes | Median |
|---|---|---|
| Trail Making Test | 15 | 13 weeks |
| Digit Span Test | 14 | 4 months |
| Stroop Color-Word Test | 13 | 13 weeks |
Explore the COVID-19 and long COVID studies
111 studies match. 40 name a library test in a primary outcome. Median size 84 participants. Median time to the primary outcome: 12 weeks.
Loading 111 studies; the filters turn on when they arrive.
2026 is partly planned starts.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 0 | 0 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 0 | 0 |
| 2011 | 0 | 0 |
| 2012 | 0 | 0 |
| 2013 | 0 | 0 |
| 2014 | 0 | 0 |
| 2015 | 0 | 0 |
| 2016 | 0 | 0 |
| 2017 | 0 | 0 |
| 2018 | 1 | 0 |
| 2019 | 0 | 0 |
| 2020 | 9 | 5 |
| 2021 | 26 | 10 |
| 2022 | 15 | 7 |
| 2023 | 28 | 6 |
| 2024 | 15 | 1 |
| 2025 | 9 | 5 |
| 2026 | 8 | 6 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 5, other 106. Interventional 82, observational 29.
As a primary outcomeSecondary or other outcome
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07881029 | Start2026 | PhaseObservational | ConditionsCOVID-19 and long COVID | Participants55 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07783074 | Start2026 | PhaseObservational | ConditionsMultiple sclerosis, Healthy volunteers, COVID-19 and long COVID, Pain and fatigue | Participants122 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07724834 | Start2026 | PhasePhase 2 | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants38 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07709234 | Start2026 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants20 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07429903 | Start2023 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants31 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07359482 | Start2026 | PhasePhase 3 | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants160 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07355751 | Start2026 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants108 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07278388 | Start2025 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants200 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07278206 | Start2025 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants66 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07051967 | Start2025 | PhaseObservational | ConditionsCOVID-19 and long COVID | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07021794 | Start2025 | PhasePhase 2 | ConditionsCOVID-19 and long COVID | Participants100 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07005921 | Start2025 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants40 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06932237 | Start2025 | PhaseObservational | ConditionsCOVID-19 and long COVID | Participants200 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06928506 | Start2025 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06897553 | Start2024 | PhaseNot applicable | ConditionsBrain injury and concussion, Depression and bipolar disorder, COVID-19 and long COVID, Anxiety, PTSD and OCD | Participants44 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06895850 | Start2021 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants20 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06850350 | Start2026 | PhaseObservational | ConditionsCOVID-19 and long COVID | Participants136 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06614309 | Start2024 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants45 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06586398 | Start2025 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants10 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06510985 | Start2024 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants120 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT06503874 | Start2024 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants58 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06476496 | Start2024 | PhaseNot applicable | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants93 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06452095 | Start2026 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06391489 | Start2024 | PhaseNot applicable | ConditionsCOVID-19 and long COVID | Participants10 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT06366724 | Start2024 | PhasePhase 2 | ConditionsCOVID-19 and long COVID, Pain and fatigue | Participants160 | Lead sponsorOther | StatusRecruiting | Library tests named
|
Questions, answered from the data
Which cognitive test do COVID-19 and long COVID trials use most?
The Trail Making Test: 36 of the 221 registered studies name it in an outcome measure, 16%. Next come the Digit Span Test (31) and the Stroop Color-Word Test (30).
Which cognitive test do COVID-19 and long COVID trials use most as a primary outcome?
The Trail Making Test, named in a primary outcome by 15 studies. 71 of the 221 studies, 32%, name a cognitive test in a primary outcome.
How many participants does a phase 2 COVID-19 and long COVID trial enroll?
Half of the phase 2 COVID-19 and long COVID studies enroll 88 participants or fewer, and the middle half enroll 40 to 142. 24 of them give a size.
How long after the start do COVID-19 and long COVID trials measure a cognitive outcome?
Half of the primary outcomes that name a library test are measured within 12 weeks of the start, and the middle half from 7 weeks to 9 months. 110 primary outcomes give a duration.
Which cognitive tests do COVID-19 and long COVID trials use together?
The Stroop Color-Word Test with the Trail Making Test most often: 18 studies name both. Next, the Digit Span Test with the Trail Making Test (17).
How many completed COVID-19 and long COVID trials have reported results?
40 of the 110 completed COVID-19 and long COVID studies, 36%, have reported results: 14 posted them on ClinicalTrials.gov, 34 have a results paper linked to the registry record, and 8 did both. The other 70 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Plan the cognitive outcomes of a COVID-19 and long COVID trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.