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    16,361Registered studies name a cognitive test in an outcome measure11,688 name a test you can run hereExplore the studies
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  1. Home
  2. /Data
  3. /Clinical trials
  4. /Benchmark

Clinical trials data

Trial design benchmark

Describe a planned trial by its condition, phase and intervention type, and see what similar registered trials did: the cognitive tests they named as primary and secondary outcomes, how many participants they enrolled and when they measured the outcome. From the 11,688 studies on ClinicalTrials.gov that name a test in the library.

Studies like yours

11,688 registered studies like this name a library test: any condition, any phase, any intervention.

Participants per study, median
60middle half 31 to 120, from 11,460 studies that give a size
Primary cognitive outcome measured, median
8 weeksmiddle half 1 week to 6 months, from 9,314 primary outcomes that give a duration

Tests they name in a primary outcome

  1. Stroop Color-Word Test7% of the studies, 785

  2. Verbal Learning6% of the studies, 711

  3. Trail Making Test6% of the studies, 709

  4. Verbal Fluency5% of the studies, 640

  5. Digit Span Test5% of the studies, 603

  6. Symbol Coding4% of the studies, 451

  7. N-Back Task3% of the studies, 381

  8. Go/No-Go Task3% of the studies, 309

  9. Continuous Performance Test2% of the studies, 265

  10. Category Fluency2% of the studies, 232

Tests they name in a secondary outcome

  1. Trail Making Test12% of the studies, 1,450

  2. Stroop Color-Word Test9% of the studies, 1,060

  3. Verbal Learning9% of the studies, 1,017

  4. Verbal Fluency9% of the studies, 997

  5. Digit Span Test8% of the studies, 939

  6. Symbol Coding8% of the studies, 908

  7. N-Back Task3% of the studies, 368

  8. Go/No-Go Task3% of the studies, 350

  9. Continuous Performance Test3% of the studies, 343

  10. Category Fluency3% of the studies, 341

Set up a study with these 5 testsSee these studies

The study starts with Stroop Color-Word Test, Verbal Learning, Trail Making Test, Verbal Fluency, Digit Span Test: the tests these studies name most in a primary outcome. You can add or remove tests before it starts.

Median participants by condition and phase

Half of the phase 2 studies with a cognitive outcome enroll 60 participants or fewer, and half of the phase 3 studies 246. Each cell is the median of the studies that give a size, with how many there are; "too few" marks fewer than 10.
Median participants per registered study by condition group and phase, with the studies that give a size
ConditionPhase 1Phase 2Phase 3Phase 4No phaseObservational
Every condition30(504)60(1,341)246(635)77(671)60(9,682)111(2,559)
Dementia and Alzheimer's30(70)90(267)543(131)101(70)60(731)280(270)
Aging, frailty and exercise40(16)60(27)too few140(14)70(1,084)160(216)
Depression and bipolar disorder30(36)69(98)111(56)60(81)71(730)140(163)
Stroke27(13)80(75)363(56)200(38)50(775)120(222)
Substance use and addiction31(74)50(139)81(16)44(32)70(463)93(69)
Parkinson's disease16(30)60(88)130(21)21(32)44(504)100(163)
Mild cognitive impairment28(14)79(74)206(12)86(23)64(587)180(111)
Cancer21(19)60(110)226(69)57(11)60(346)100(151)
Sleep and sleep disorders34(17)61(56)158(30)48(34)60(463)100(119)
Anxiety, PTSD and OCD38(15)62(47)70(12)65(21)69(465)109(81)
Cardiovascular diseasetoo few69(28)238(28)200(41)100(377)200(167)
Pain and fatigue32(17)100(55)72(29)102(25)59(393)93(115)
Healthy volunteers30(73)64(13)too few44(20)60(432)121(72)
Schizophrenia and psychosis31(29)57(82)142(33)60(51)60(362)100(43)
Obesity and diabetes41(13)57(34)306(12)100(30)61(390)163(120)
Delirium, surgery and intensive caretoo few93(22)290(24)136(61)107(268)150(217)
Multiple sclerosis28(14)60(57)828(62)111(23)50(291)86(121)
Brain injury and concussion40(13)43(29)133(12)40(13)41(288)92(61)
ADHD22(10)43(26)114(17)78(37)60(207)104(38)
Cognitive impairment and declinetoo few40(15)too few80(19)60(214)122(72)
Hearing losstoo few78(11)too fewtoo few40(169)80(47)
COVID-19 and long COVIDtoo few88(24)too fewtoo few60(96)194(77)
Autismtoo few46(20)too fewtoo few60(133)126(21)
Epilepsytoo few32(10)too fewtoo few46(70)120(27)
Lung diseasetoo fewtoo fewtoo fewtoo few60(53)98(38)

Every registered study in the group counts here, whichever tests it names, as on the condition pages; the benchmark above reads the studies that name a library test. Enrollment is as registered: actual for a finished study, planned for one still recruiting. “No phase” is the registry's “not applicable”, used for behavioral and device trials.

How the studies are counted

For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.

The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.

A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.

A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.

The benchmark counts a test in a primary outcome when a primary outcome measure of the study names it, and its timing is the latest time point of that outcome. The section's main page holds every study, with filters for test, sponsor, status, country, size and start year.

Plan the cognitive outcomes of your trial

Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.

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