ConductCognition

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    1. Verbal Fluency TestGradeA
    2. Stroop Color-Word TestGradeA
    3. Trail Making TestGradeA
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    8. Verbal Learning TestGradeA
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    • Motor and AttentionGradeA−29 min
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    • Cognitive outcomes, 2026

    Conditions

    Registered studies

    • Dementia and Alzheimer's1,673
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    All 25 conditions
    16,361Registered studies name a cognitive test in an outcome measure11,688 name a test you can run hereExplore the studies
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  1. Home
  2. /Data
  3. /Clinical trials
  4. /Conditions
  5. /Dementia and Alzheimer's

Clinical trials data

Cognitive tests in dementia and Alzheimer's trials: 1,673 registered studies

Every registered dementia and Alzheimer's disease study on ClinicalTrials.gov that names a cognitive test in an outcome measure: the tests used most, how often as a primary outcome, which tests go together, how large the studies are and when they measure the outcome.

Registered dementia and Alzheimer's disease studies name a cognitive test in an outcome
1,673
Name one in a primary outcome
661
See the tests
Median participants per study
83
By phase
Led by industry
405

The tests dementia and Alzheimer's trials use most

The Trail Making Test leads: 273 of the 1,673 studies name it, 16%. Next comes Verbal Fluency (248). As a primary outcome, Verbal Learning leads with 102 studies.

  1. 1

    Trail Making Test273 studies, 83 as a primary outcome

  2. 2

    Verbal Fluency248 studies, 95 as a primary outcome

  3. 3

    Verbal Learning224 studies, 102 as a primary outcome

  4. 4

    Digit Span Test181 studies, 61 as a primary outcome

  5. 5

    Category Fluency167 studies, 50 as a primary outcome

  6. 6

    Symbol Coding117 studies, 41 as a primary outcome

  7. 7

    Stroop Color-Word Test116 studies, 49 as a primary outcome

  8. 8

    Picture Naming Test104 studies, 38 as a primary outcome

  9. 9

    Short Story Recall91 studies, 36 as a primary outcome

  10. 10

    Selective Reminding Task76 studies, 34 as a primary outcome

  11. 11

    Delayed Recall Module71 studies, 17 as a primary outcome

  12. 12

    Clock Drawing Task69 studies, 28 as a primary outcome

  13. 13

    Complex Figure Copy and Recall53 studies, 23 as a primary outcome

  14. 14

    N-Back Task44 studies, 21 as a primary outcome

  15. 15

    Cancellation Test42 studies, 12 as a primary outcome

  16. 16

    Paired Associate Learning34 studies, 9 as a primary outcome

  17. 17

    Task Switching Test31 studies, 10 as a primary outcome

  18. 18

    Choice Reaction Time25 studies, 14 as a primary outcome

  19. 19

    Matrix Reasoning25 studies, 8 as a primary outcome

  20. 20

    Face-name Memory Task22 studies, 13 as a primary outcome

  21. 21

    Go/No-Go Task20 studies, 9 as a primary outcome

  22. 22

    Line Angle Matching16 studies, 6 as a primary outcome

  23. 23

    Continuous Performance Test14 studies, 6 as a primary outcome

  24. 24

    Simple Reaction Time13 studies, 7 as a primary outcome

  25. 25

    Dimensional Change Card Sort13 studies, 6 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

48% of dementia and Alzheimer's disease studies name only instruments outside the library, such as clinician-administered screening scales. They count in every figure on this page and are not listed. The explorer below holds all 109 tests.

Tests used together

The pairs of tests dementia and Alzheimer's disease studies name together most often.
  1. Digit Span Test and Trail Making Test104 studies name both
  2. Trail Making Test and Verbal Fluency101 studies name both
  3. Trail Making Test and Verbal Learning99 studies name both
  4. Category Fluency and Verbal Fluency93 studies name both
  5. Verbal Fluency and Verbal Learning80 studies name both
  6. Digit Span Test and Verbal Learning79 studies name both
  7. Digit Span Test and Verbal Fluency76 studies name both
  8. Category Fluency and Trail Making Test71 studies name both
  9. Category Fluency and Digit Span Test65 studies name both
  10. Stroop Color-Word Test and Trail Making Test63 studies name both

Studies by start year

Each study counted once. 2026 is partly planned starts.
01002000: 4 studies, 2 with a test as a primary outcome20002001: 3 studies, 1 with a test as a primary outcome2002: 4 studies, 2 with a test as a primary outcome2003: 10 studies, 3 with a test as a primary outcome2004: 10 studies, 5 with a test as a primary outcome2005: 13 studies, 6 with a test as a primary outcome20052006: 14 studies, 6 with a test as a primary outcome2007: 33 studies, 9 with a test as a primary outcome2008: 29 studies, 12 with a test as a primary outcome2009: 35 studies, 11 with a test as a primary outcome2010: 45 studies, 14 with a test as a primary outcome20102011: 37 studies, 17 with a test as a primary outcome2012: 44 studies, 16 with a test as a primary outcome2013: 49 studies, 23 with a test as a primary outcome2014: 56 studies, 19 with a test as a primary outcome2015: 62 studies, 27 with a test as a primary outcome20152016: 61 studies, 24 with a test as a primary outcome2017: 74 studies, 25 with a test as a primary outcome2018: 87 studies, 38 with a test as a primary outcome2019: 127 studies, 53 with a test as a primary outcome2020: 90 studies, 42 with a test as a primary outcome20202021: 109 studies, 45 with a test as a primary outcome2022: 121 studies, 48 with a test as a primary outcome2023: 119 studies, 47 with a test as a primary outcome2024: 135 studies, 59 with a test as a primary outcome2025: 169 studies, 69 with a test as a primary outcome20252026: 118 studies, 34 with a test as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table
Registered studies by start year
Start yearStudiesA test as a primary outcome
200042
200131
200242
2003103
2004105
2005136
2006146
2007339
20082912
20093511
20104514
20113717
20124416
20134923
20145619
20156227
20166124
20177425
20188738
201912753
20209042
202110945
202212148
202311947
202413559
202516969
202611834

Phases and sponsors

By phase

  • Early phase 118 studies, 5 as a primary outcome
  • Phase 172 studies, 20 as a primary outcome
  • Phase 1/255 studies, 18 as a primary outcome
  • Phase 2274 studies, 73 as a primary outcome
  • Phase 2/328 studies, 15 as a primary outcome
  • Phase 3131 studies, 24 as a primary outcome
  • Phase 473 studies, 21 as a primary outcome
  • Not applicable746 studies, 354 as a primary outcome
  • Observational276 studies, 131 as a primary outcome

Sponsors and study types

Lead sponsor: industry 405, NIH 6, universities, hospitals and others 1,262. Interventional 1,397, observational 276.

Status, results, interventions and countries

Status

  • Recruiting308 studies, 113 as a primary outcome
  • Not yet recruiting113 studies, 35 as a primary outcome
  • Active, not recruiting66 studies, 20 as a primary outcome
  • Completed778 studies, 328 as a primary outcome
  • Stopped early165 studies, 64 as a primary outcome
  • Status unknown243 studies, 101 as a primary outcome

What they test

  • Behavioral282 studies, 136 as a primary outcome
  • Drug603 studies, 163 as a primary outcome
  • Device268 studies, 124 as a primary outcome
  • Dietary supplement65 studies, 26 as a primary outcome
  • Procedure74 studies, 37 as a primary outcome
  • Diagnostic test54 studies, 20 as a primary outcome
  • Biological56 studies, 11 as a primary outcome
  • Radiation12 studies, 5 as a primary outcome
  • Combination product7 studies, 5 as a primary outcome
  • Genetic6 studies, 4 as a primary outcome
  • Other370 studies, 160 as a primary outcome
  • None given129 studies, 64 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

Where their sites are

  • United States593 studies, 232 as a primary outcome
  • China186 studies, 58 as a primary outcome
  • Canada163 studies, 47 as a primary outcome
  • Spain147 studies, 52 as a primary outcome
  • France145 studies, 44 as a primary outcome
  • Italy130 studies, 50 as a primary outcome
  • United Kingdom126 studies, 42 as a primary outcome
  • Germany110 studies, 30 as a primary outcome
  • South Korea98 studies, 22 as a primary outcome
  • Australia96 studies, 22 as a primary outcome
  • Japan79 studies, 21 as a primary outcome
  • Taiwan74 studies, 29 as a primary outcome

72 countries in all. A study with sites in several counts in each; 122 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed dementia and Alzheimer's disease studies: 437 of 778, 56%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed dementia and Alzheimer's disease studies and every completed study, by how they reported results
ResultsCompleted dementia and Alzheimer's disease studiesEvery completed study
Results on ClinicalTrials.gov and a paper127, 16%776, 10%
Results on ClinicalTrials.gov only135, 17%1,139, 14%
A results paper only175, 22%1,711, 22%
Neither341, 44%4,327, 54%

How many participants they enroll

Enrollment as registered: actual for a finished study, planned for one still recruiting.
1020501002005001,000
  • Early phase 140 median, 19 to 88
  • Phase 130 median, 17 to 55
  • Phase 1/233 median, 15 to 49
  • Phase 290 median, 43 to 196
  • Phase 2/3228 median, 59 to 434
  • Phase 3543 median, 223 to 1,154
  • Phase 4101 median, 50 to 200
  • Not applicable60 median, 33 to 129
  • Observational280 median, 100 to 1,000
Participants per study. The bar spans the middle half of the studies in each phase, the mark is the median, and the axis is logarithmic. Phases with fewer than 10 studies that give a size are left out.
Show as a table
Participants per dementia and Alzheimer's disease study by phase
PhaseStudies with a sizeMedianMiddle half
Early phase 1184019 to 88
Phase 1703017 to 55
Phase 1/2543315 to 49
Phase 22679043 to 196
Phase 2/32822859 to 434
Phase 3131543223 to 1,154
Phase 47010150 to 200
Not applicable7316033 to 129
Observational270280100 to 1,000

When the cognitive outcome is measured

Half of the primary outcomes that name a library test are measured within 5 months of the start, and the middle half from 6 weeks to 12 months. 839 primary outcomes give a duration.

Latest time point of each outcome

  • Within a day179 outcomes, 102 as a primary outcome
  • Up to 4 weeks241 outcomes, 94 as a primary outcome
  • 1 to 3 months439 outcomes, 178 as a primary outcome
  • 3 to 6 months476 outcomes, 168 as a primary outcome
  • 6 to 12 months429 outcomes, 119 as a primary outcome
  • 1 to 2 years265 outcomes, 73 as a primary outcome
  • Over 2 years225 outcomes, 105 as a primary outcome
  • No duration given126 outcomes, 70 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

2,254 of the 2,380 outcome measures give a duration. A single visit counts as within a day.

Median time to the primary outcome, by test

Median weeks to the latest time point of each test's primary outcomes
TestPrimary outcomesMedian
Verbal Learning916 months
Verbal Fluency875 months
Trail Making Test774 months
Digit Span Test556 months
Stroop Color-Word Test479 weeks
Category Fluency456 months
Symbol Coding386 months
Picture Naming Test3613 weeks
Short Story Recall3612 months
Selective Reminding Task3210 months

Explore the dementia and Alzheimer's disease studies

The 878 dementia and Alzheimer's disease studies that name a test in the library, with filters for test, phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.
ConditionDementia and Alzheimer's

878 studies match. 380 name a library test in a primary outcome. Median size 77 participants. Median time to the primary outcome: 5 months.

Loading 878 studies; the filters turn on when they arrive.

By start year
02550751002000: 0 studies, 0 naming a library test in a primary outcome20002001: 3 studies, 1 naming a library test in a primary outcome2002: 1 studies, 1 naming a library test in a primary outcome2003: 3 studies, 1 naming a library test in a primary outcome2004: 5 studies, 3 naming a library test in a primary outcome2005: 13 studies, 5 naming a library test in a primary outcome20052006: 6 studies, 5 naming a library test in a primary outcome2007: 12 studies, 3 naming a library test in a primary outcome2008: 13 studies, 7 naming a library test in a primary outcome2009: 22 studies, 7 naming a library test in a primary outcome2010: 29 studies, 12 naming a library test in a primary outcome20102011: 23 studies, 12 naming a library test in a primary outcome2012: 27 studies, 15 naming a library test in a primary outcome2013: 32 studies, 16 naming a library test in a primary outcome2014: 26 studies, 14 naming a library test in a primary outcome2015: 41 studies, 16 naming a library test in a primary outcome20152016: 32 studies, 12 naming a library test in a primary outcome2017: 43 studies, 18 naming a library test in a primary outcome2018: 46 studies, 21 naming a library test in a primary outcome2019: 82 studies, 33 naming a library test in a primary outcome2020: 41 studies, 20 naming a library test in a primary outcome20202021: 56 studies, 27 naming a library test in a primary outcome2022: 66 studies, 29 naming a library test in a primary outcome2023: 57 studies, 24 naming a library test in a primary outcome2024: 63 studies, 26 naming a library test in a primary outcome2025: 81 studies, 32 naming a library test in a primary outcome20252026: 48 studies, 18 naming a library test in a primary outcome

2026 is partly planned starts. Not shown: 1 that started before 2000 and 6 planned to start after 2026.

Show as a table
Matching studies by start year
Start yearStudiesAs a primary outcome
200000
200131
200211
200331
200453
2005135
200665
2007123
2008137
2009227
20102912
20112312
20122715
20133216
20142614
20154116
20163212
20174318
20184621
20198233
20204120
20215627
20226629
20235724
20246326
20258132
20264818

Library tests named most

Largest condition groups

  • Dementia and Alzheimer's878 studies, 380 as a primary outcome
  • Mild cognitive impairment211 studies, 107 as a primary outcome
  • Aging, frailty and exercise67 studies, 33 as a primary outcome
  • Parkinson's disease41 studies, 20 as a primary outcome
  • Healthy volunteers25 studies, 17 as a primary outcome
  • Sleep and sleep disorders25 studies, 12 as a primary outcome
  • Depression and bipolar disorder23 studies, 13 as a primary outcome
  • Obesity and diabetes23 studies, 14 as a primary outcome
  • Stroke17 studies, 9 as a primary outcome
  • Cardiovascular disease13 studies, 4 as a primary outcome
  • Cancer12 studies, 7 as a primary outcome
  • Hearing loss11 studies, 6 as a primary outcome

Phases

Participants

Lead sponsor: industry 189, NIH 4, other 685. Interventional 761, observational 117.

As a primary outcomeSecondary or other outcome

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
StudyStartPhaseConditionsParticipantsLead sponsorStatusLibrary tests named, with the latest time point
NCT07883148Start2024PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants52Lead sponsorOtherStatusCompletedLibrary tests named
  • Trail Making TestSecondary8 months
  • Verbal LearningSecondary8 months
  • Verbal FluencySecondary8 months
  • Digit Span TestSecondary8 months
  • Complex Figure Copy and RecallSecondary8 months
NCT07882251Start2021PhaseNot applicableConditionsDementia and Alzheimer'sParticipants80Lead sponsorOtherStatusCompletedLibrary tests named
  • Stroop Color-Word TestPrimary5 weeks
  • Verbal LearningPrimary5 weeks
  • Digit Span TestPrimary5 weeks
  • Category FluencyPrimary5 weeks
  • Complex Figure Copy and RecallPrimary5 weeks
  • Corsi Block-Tapping TestPrimary5 weeks
  • Line Angle MatchingPrimary5 weeks
NCT07856043Start2026PhasePhase 1ConditionsDementia and Alzheimer's, Mild cognitive impairment, Cardiovascular diseaseParticipants18Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Trail Making TestSecondary12 weeks
  • Symbol CodingSecondary12 weeks
  • Selective Reminding TaskSecondary12 weeks
NCT07842146Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants60Lead sponsorOtherStatusRecruitingLibrary tests named
  • Verbal FluencySecondary11 months
  • Symbol CodingSecondary11 months
  • Category FluencySecondary11 months
  • Delayed Recall ModuleSecondary11 months
NCT07842029Start2025PhaseObservationalConditionsDementia and Alzheimer'sParticipants1,000Lead sponsorIndustryStatusRecruitingLibrary tests named
  • Task Switching TestSecondary12 months
NCT07841145Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Aging, frailty and exerciseParticipants68Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Trail Making TestSecondary13 weeks
  • Verbal FluencySecondary13 weeks
NCT07839650Start2026PhaseNot applicableConditionsDementia and Alzheimer'sParticipants30Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestPrimary6 months
  • Verbal LearningPrimary6 months
  • Category FluencyPrimary6 months
  • Task Switching TestPrimary6 months
  • Face-name Memory TaskPrimary6 months
NCT07824128Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's diseaseParticipants120Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Alternative Uses TaskPrimary8 months
NCT07786116Start2025PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's disease, Sleep and sleep disordersParticipants215Lead sponsorOtherStatusRecruitingLibrary tests named
  • Category FluencyOther outcome18 months
NCT07779863Start2027PhaseNot applicableConditionsDementia and Alzheimer'sParticipants188Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Digit Span TestSecondary12 months
NCT07775833Start2026PhaseNot applicableConditionsDementia and Alzheimer'sParticipants600Lead sponsorOtherStatusRecruitingLibrary tests named
  • Verbal LearningSecondary2 years
NCT07766993Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants100Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Digit Span TestPrimary12 months
NCT07741071Start2026PhasePhase 2ConditionsDementia and Alzheimer'sParticipants270Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestSecondary2 years
  • Verbal FluencySecondary2 years
NCT07731334Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants384Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestSecondary12 months
  • Stroop Color-Word TestSecondary12 months
  • Verbal LearningSecondary12 months
  • Verbal FluencySecondary12 months
  • Digit Span TestSecondary12 months
  • Complex Figure Copy and RecallSecondary12 months
  • Corsi Block-Tapping TestSecondary12 months
  • Oddball Target DetectionSecondary
NCT07730671Start2026PhaseObservationalConditionsDementia and Alzheimer'sParticipants121Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Stroop Color-Word TestPrimary5 years
  • Short Story RecallPrimary5 years
  • Selective Reminding TaskPrimary5 years
NCT07722169Start2026PhaseNot applicableConditionsDementia and Alzheimer'sParticipants48Lead sponsorOtherStatusNot yet recruitingLibrary tests named
  • Verbal FluencySecondary13 weeks
  • Digit Span TestSecondary13 weeks
  • Category FluencySecondary13 weeks
  • Picture Naming TestSecondary13 weeks
  • Matrix ReasoningSecondary13 weeks
  • Token Commands TaskSecondary13 weeks
NCT07717411Start2026PhasePhase 3ConditionsDementia and Alzheimer'sParticipants1,600Lead sponsorIndustryStatusRecruitingLibrary tests named
  • Trail Making TestSecondary4 years
  • Symbol CodingSecondary4 years
  • Category FluencySecondary4 years
  • Short Story RecallSecondary4 years
  • Selective Reminding TaskSecondary4 years
NCT07700615Start2025PhasePhase 4ConditionsDementia and Alzheimer'sParticipants120Lead sponsorIndustryStatusCompletedLibrary tests named
  • Trail Making TestSecondary9 weeks
  • Symbol CodingSecondary9 weeks
NCT07692542Start2026PhaseNot applicableConditionsDementia and Alzheimer'sParticipants40Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestSecondary2 weeks
  • Stroop Color-Word TestSecondary2 weeks
NCT07673770Start2026PhaseNot applicableConditionsDementia and Alzheimer'sParticipants30Lead sponsorOtherStatusRecruitingLibrary tests named
  • Digit Span TestPrimary4 months
NCT07672977Start2025PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants30Lead sponsorIndustryStatusRecruitingLibrary tests named
  • Verbal LearningOther outcome7 months
  • Digit Span TestOther outcome7 months
  • Short Story RecallOther outcome7 months
  • Symbol Scan TaskOther outcome7 months
  • Word Pair LearningOther outcome7 months
NCT07667478Start2026PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants40Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestPrimary6 months
  • Verbal LearningPrimary6 months
  • Digit Span TestPrimary6 months
  • Picture Naming TestPrimary6 months
NCT07664865Start2024PhaseObservationalConditionsDementia and Alzheimer'sParticipants250Lead sponsorOtherStatusCompletedLibrary tests named
  • Stroop Color-Word TestPrimarysame day
  • Verbal FluencyPrimarysame day
  • Symbol CodingPrimarysame day
  • Picture Naming TestPrimarysame day
  • Clock Drawing TaskPrimarysame day
  • Complex Figure Copy and RecallPrimarysame day
  • Emoji Emotion RecognitionPrimarysame day
  • Selective Reminding TaskPrimarysame day
NCT07651787Start2025PhaseNot applicableConditionsDementia and Alzheimer's, Mild cognitive impairmentParticipants40Lead sponsorOtherStatusRecruitingLibrary tests named
  • Symbol CodingOther outcome12 weeks
  • N-Back TaskPrimary12 weeks
  • Dimensional Change Card SortOther outcome12 weeks
  • Size Order Memory TestOther outcome12 weeks
  • Pattern and Letter ComparisonOther outcome12 weeks
  • Picture Order Memory TestOther outcome12 weeks
NCT07651085Start2024PhaseObservationalConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's disease, Sleep and sleep disordersParticipants65Lead sponsorOtherStatusActive, not recruitingLibrary tests named
  • Verbal LearningPrimary
  • Verbal FluencyPrimary
  • Category FluencyPrimary
  • Clock Drawing TaskPrimary

Page 1 of 36

Questions, answered from the data

Which cognitive test do dementia and Alzheimer's trials use most?

The Trail Making Test: 273 of the 1,673 registered studies name it in an outcome measure, 16%. Next come Verbal Fluency (248) and Verbal Learning (224).

Which cognitive test do dementia and Alzheimer's trials use most as a primary outcome?

Verbal Learning, named in a primary outcome by 102 studies. 661 of the 1,673 studies, 40%, name a cognitive test in a primary outcome.

How many participants does a phase 2 dementia and Alzheimer's trial enroll?

Half of the phase 2 dementia and Alzheimer's disease studies enroll 90 participants or fewer, and the middle half enroll 43 to 196. 267 of them give a size.

How long after the start do dementia and Alzheimer's trials measure a cognitive outcome?

Half of the primary outcomes that name a library test are measured within 5 months of the start, and the middle half from 6 weeks to 12 months. 839 primary outcomes give a duration.

Which cognitive tests do dementia and Alzheimer's trials use together?

The Digit Span Test with the Trail Making Test most often: 104 studies name both. Next, the Trail Making Test with Verbal Fluency (101).

How many completed dementia and Alzheimer's trials have reported results?

437 of the 778 completed dementia and Alzheimer's disease studies, 56%, have reported results: 262 posted them on ClinicalTrials.gov, 302 have a results paper linked to the registry record, and 127 did both. The other 341 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.

Other conditions

  • Mild cognitive impairment341 shared
  • Aging, frailty and exercise109 shared
  • Parkinson's disease79 shared
  • Depression and bipolar disorder56 shared
  • Sleep and sleep disorders43 shared
  • Stroke40 shared
  • Obesity and diabetes40 shared
  • Cancer36 shared
  • Healthy volunteers32 shared
  • Cardiovascular disease25 shared
  • Delirium, surgery and intensive care24 shared
  • Hearing loss17 shared
  • Anxiety, PTSD and OCD16 shared
  • Schizophrenia and psychosis15 shared
  • Pain and fatigue11 shared
  • Brain injury and concussion7 shared
  • Epilepsy6 shared
  • Substance use and addiction5 shared
  • Lung disease4 shared
  • Multiple sclerosis3 shared
  • COVID-19 and long COVID3 shared
  • ADHD1 shared
  • Cognitive impairment and decline354 studies
  • Autism200 studies

All 16,361 registered studies, by test, condition, phase and year.

How the studies are counted

For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.

The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.

A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.

A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.

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