Clinical trials data
Cognitive tests in Parkinson's disease trials: 892 registered studies
Every registered Parkinson's disease study on ClinicalTrials.gov that names a cognitive test in an outcome measure: the tests used most, how often as a primary outcome, which tests go together, how large the studies are and when they measure the outcome.
- Registered Parkinson's disease studies name a cognitive test in an outcome
- 892
- Led by industry
- 86
The tests Parkinson's disease trials use most
The Trail Making Test leads: 156 of the 892 studies name it, 17%. Next comes Verbal Fluency (140). As a primary outcome, Verbal Fluency leads with 45 studies.
- 1
Trail Making Test156 studies, 38 as a primary outcome
- 2
Verbal Fluency140 studies, 45 as a primary outcome
- 3
Stroop Color-Word Test126 studies, 39 as a primary outcome
- 4
Digit Span Test86 studies, 15 as a primary outcome
- 5
Verbal Learning61 studies, 22 as a primary outcome
- 6
Category Fluency44 studies, 13 as a primary outcome
- 7
Symbol Coding41 studies, 10 as a primary outcome
- 8
Picture Naming Test37 studies, 7 as a primary outcome
- 9
Clock Drawing Task33 studies, 10 as a primary outcome
- 10
Line Angle Matching25 studies, 6 as a primary outcome
- 11
Finger Tapping Task24 studies, 8 as a primary outcome
- 12
Card Sorting Test (Berg)23 studies, 6 as a primary outcome
- 13
Complex Figure Copy and Recall21 studies, 5 as a primary outcome
- 14
Go/No-Go Task18 studies, 8 as a primary outcome
- 15
Choice Reaction Time15 studies, 11 as a primary outcome
- 16
Simple Reaction Time14 studies, 6 as a primary outcome
- 17
Task Switching Test14 studies, 5 as a primary outcome
- 18
Matrix Reasoning14 studies, 4 as a primary outcome
- 19
N-Back Task13 studies, 4 as a primary outcome
- 20
Tower Planning13 studies, 4 as a primary outcome
- 21
Short Story Recall11 studies, 4 as a primary outcome
- 22
Stop-Signal Task10 studies, 6 as a primary outcome
- 23
Eriksen Flanker Task10 studies, 4 as a primary outcome
- 24
Psychomotor Vigilance Task10 studies, 2 as a primary outcome
- 25
Delayed Recall Module9 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
47% of Parkinson's disease studies name only instruments outside the library, such as clinician-administered screening scales. They count in every figure on this page and are not listed. The explorer below holds all 93 tests.
Tests used together
- Stroop Color-Word Test and Trail Making Test68 studies name both
- Trail Making Test and Verbal Fluency50 studies name both
- Digit Span Test and Verbal Fluency43 studies name both
- Digit Span Test and Trail Making Test42 studies name both
- Stroop Color-Word Test and Verbal Fluency42 studies name both
- Digit Span Test and Stroop Color-Word Test37 studies name both
- Verbal Fluency and Verbal Learning33 studies name both
- Trail Making Test and Verbal Learning32 studies name both
- Category Fluency and Verbal Fluency29 studies name both
- Picture Naming Test and Verbal Fluency25 studies name both
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 2 | 0 |
| 2004 | 1 | 0 |
| 2005 | 0 | 0 |
| 2006 | 2 | 0 |
| 2007 | 6 | 3 |
| 2008 | 1 | 0 |
| 2009 | 9 | 5 |
| 2010 | 8 | 4 |
| 2011 | 19 | 6 |
| 2012 | 21 | 6 |
| 2013 | 28 | 6 |
| 2014 | 24 | 5 |
| 2015 | 25 | 13 |
| 2016 | 31 | 8 |
| 2017 | 48 | 13 |
| 2018 | 49 | 13 |
| 2019 | 57 | 23 |
| 2020 | 69 | 17 |
| 2021 | 80 | 29 |
| 2022 | 64 | 21 |
| 2023 | 76 | 22 |
| 2024 | 82 | 23 |
| 2025 | 88 | 26 |
| 2026 | 100 | 33 |
Phases and sponsors
By phase
- Early phase 110 studies, 1 as a primary outcome
- Phase 134 studies, 5 as a primary outcome
- Phase 1/222 studies, 9 as a primary outcome
- Phase 291 studies, 13 as a primary outcome
- Phase 2/36 studies, 1 as a primary outcome
- Phase 321 studies, 6 as a primary outcome
- Phase 432 studies, 11 as a primary outcome
- Not applicable509 studies, 153 as a primary outcome
- Observational167 studies, 77 as a primary outcome
Sponsors and study types
Lead sponsor: industry 86, NIH 3, universities, hospitals and others 803. Interventional 725, observational 167.
Status, results, interventions and countries
Status
- Recruiting196 studies, 69 as a primary outcome
- Not yet recruiting56 studies, 19 as a primary outcome
- Active, not recruiting33 studies, 14 as a primary outcome
- Completed392 studies, 121 as a primary outcome
- Stopped early54 studies, 16 as a primary outcome
- Status unknown161 studies, 37 as a primary outcome
What they test
- Behavioral153 studies, 51 as a primary outcome
- Drug195 studies, 42 as a primary outcome
- Device209 studies, 56 as a primary outcome
- Dietary supplement22 studies, 4 as a primary outcome
- Procedure41 studies, 9 as a primary outcome
- Diagnostic test31 studies, 15 as a primary outcome
- Biological16 studies, 3 as a primary outcome
- Radiation5 studies, 3 as a primary outcome
- Combination product1 studies, 1 as a primary outcome
- Genetic9 studies, 4 as a primary outcome
- Other241 studies, 88 as a primary outcome
- None given76 studies, 38 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States265 studies, 101 as a primary outcome
- Italy74 studies, 29 as a primary outcome
- China71 studies, 15 as a primary outcome
- Canada61 studies, 16 as a primary outcome
- France58 studies, 11 as a primary outcome
- United Kingdom49 studies, 6 as a primary outcome
- Türkiye47 studies, 21 as a primary outcome
- Germany40 studies, 4 as a primary outcome
- Spain37 studies, 12 as a primary outcome
- Netherlands36 studies, 5 as a primary outcome
- Brazil28 studies, 8 as a primary outcome
- Switzerland28 studies, 7 as a primary outcome
50 countries in all. A study with sites in several counts in each; 42 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed Parkinson's disease studies: 170 of 392, 43%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed Parkinson's disease studies | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 36, 9% | 776, 10% |
| Results on ClinicalTrials.gov only | 58, 15% | 1,139, 14% |
| A results paper only | 76, 19% | 1,711, 22% |
| Neither | 222, 57% | 4,327, 54% |
How many participants they enroll
- Phase 116 median, 9 to 24
- Phase 1/217 median, 13 to 40
- Phase 260 median, 31 to 100
- Phase 3130 median, 80 to 410
- Phase 421 median, 17 to 56
- Not applicable44 median, 25 to 80
- Observational100 median, 50 to 221
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Phase 1 | 30 | 16 | 9 to 24 |
| Phase 1/2 | 21 | 17 | 13 to 40 |
| Phase 2 | 88 | 60 | 31 to 100 |
| Phase 3 | 21 | 130 | 80 to 410 |
| Phase 4 | 32 | 21 | 17 to 56 |
| Not applicable | 504 | 44 | 25 to 80 |
| Observational | 163 | 100 | 50 to 221 |
When the cognitive outcome is measured
Latest time point of each outcome
- Within a day207 outcomes, 97 as a primary outcome
- Up to 4 weeks187 outcomes, 51 as a primary outcome
- 1 to 3 months318 outcomes, 79 as a primary outcome
- 3 to 6 months168 outcomes, 42 as a primary outcome
- 6 to 12 months78 outcomes, 19 as a primary outcome
- 1 to 2 years49 outcomes, 9 as a primary outcome
- Over 2 years51 outcomes, 15 as a primary outcome
- No duration given58 outcomes, 24 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
1,058 of the 1,116 outcome measures give a duration. A single visit counts as within a day.
Median time to the primary outcome, by test
| Test | Primary outcomes | Median |
|---|---|---|
| Verbal Fluency | 40 | 12 weeks |
| Stroop Color-Word Test | 38 | 8 weeks |
| Trail Making Test | 36 | 6 weeks |
| Verbal Learning | 20 | 11 weeks |
| Digit Span Test | 15 | 4 weeks |
| Category Fluency | 11 | 4 weeks |
| Choice Reaction Time | 10 | 8 weeks |
Explore the Parkinson's disease studies
475 studies match. 183 name a library test in a primary outcome. Median size 45 participants. Median time to the primary outcome: 6 weeks.
Loading 475 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 1 with no start year.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 2 | 0 |
| 2004 | 1 | 0 |
| 2005 | 0 | 0 |
| 2006 | 1 | 0 |
| 2007 | 5 | 3 |
| 2008 | 1 | 0 |
| 2009 | 7 | 4 |
| 2010 | 5 | 4 |
| 2011 | 13 | 6 |
| 2012 | 11 | 5 |
| 2013 | 16 | 5 |
| 2014 | 15 | 4 |
| 2015 | 12 | 5 |
| 2016 | 16 | 5 |
| 2017 | 25 | 8 |
| 2018 | 29 | 8 |
| 2019 | 33 | 15 |
| 2020 | 30 | 13 |
| 2021 | 42 | 18 |
| 2022 | 33 | 11 |
| 2023 | 40 | 17 |
| 2024 | 37 | 19 |
| 2025 | 40 | 10 |
| 2026 | 60 | 23 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 33, NIH 1, other 441. Interventional 403, observational 72.
As a primary outcomeSecondary or other outcome
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07907718 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants50 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07886450 | Start2026 | PhaseObservational | ConditionsParkinson's disease | Participants128 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07882108 | Start2025 | PhaseNot applicable | ConditionsParkinson's disease, Sleep and sleep disorders | Participants72 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07865260 | Start2026 | PhaseNot applicable | ConditionsMild cognitive impairment, Stroke, Parkinson's disease | Participants80 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07860294 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07846007 | Start2024 | PhaseNot applicable | ConditionsParkinson's disease | Participants15 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07838675 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07833748 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants12 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07832695 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants90 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07827963 | Start2026 | PhaseObservational | ConditionsMild cognitive impairment, Parkinson's disease | Participants80 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07824128 | Start2026 | PhaseNot applicable | ConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's disease | Participants120 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07815964 | Start2026 | PhaseObservational | ConditionsParkinson's disease | Participants100 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07813156 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants24 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07786116 | Start2025 | PhaseNot applicable | ConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's disease, Sleep and sleep disorders | Participants215 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07777419 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants20 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07721688 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07718659 | Start2026 | PhasePhase 1 | ConditionsParkinson's disease | Participants8 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07714772 | Start2026 | PhaseObservational | ConditionsParkinson's disease, Sleep and sleep disorders | Participants50 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07705373 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants200 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07703137 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07702929 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants48 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07678983 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants66 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07651085 | Start2024 | PhaseObservational | ConditionsDementia and Alzheimer's, Mild cognitive impairment, Parkinson's disease, Sleep and sleep disorders | Participants65 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07641569 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants39 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07641556 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
Questions, answered from the data
Which cognitive test do Parkinson's disease trials use most?
The Trail Making Test: 156 of the 892 registered studies name it in an outcome measure, 17%. Next come Verbal Fluency (140) and the Stroop Color-Word Test (126).
Which cognitive test do Parkinson's disease trials use most as a primary outcome?
Verbal Fluency, named in a primary outcome by 45 studies. 276 of the 892 studies, 31%, name a cognitive test in a primary outcome.
How many participants does a phase 2 Parkinson's disease trial enroll?
Half of the phase 2 Parkinson's disease studies enroll 60 participants or fewer, and the middle half enroll 31 to 100. 88 of them give a size.
How long after the start do Parkinson's disease trials measure a cognitive outcome?
Half of the primary outcomes that name a library test are measured within 6 weeks of the start, and the middle half from the first day to 14 weeks. 312 primary outcomes give a duration.
Which cognitive tests do Parkinson's disease trials use together?
The Stroop Color-Word Test with the Trail Making Test most often: 68 studies name both. Next, the Trail Making Test with Verbal Fluency (50).
How many completed Parkinson's disease trials have reported results?
170 of the 392 completed Parkinson's disease studies, 43%, have reported results: 94 posted them on ClinicalTrials.gov, 112 have a results paper linked to the registry record, and 36 did both. The other 222 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Plan the cognitive outcomes of a Parkinson's disease trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.