Clinical trials data
Cognitive tests in obesity and diabetes trials: 627 registered studies
Every registered obesity and diabetes study on ClinicalTrials.gov that names a cognitive test in an outcome measure: the tests used most, how often as a primary outcome, which tests go together, how large the studies are and when they measure the outcome.
- Registered obesity and diabetes studies name a cognitive test in an outcome
- 627
- Led by industry
- 25
The tests obesity and diabetes trials use most
The Stroop Color-Word Test leads: 103 of the 627 studies name it, 16%. Next comes the Trail Making Test (102). As a primary outcome, the Trail Making Test leads with 35 studies.
- 1
Stroop Color-Word Test103 studies, 34 as a primary outcome
- 2
Trail Making Test102 studies, 35 as a primary outcome
- 3
Verbal Learning74 studies, 27 as a primary outcome
- 4
Digit Span Test64 studies, 26 as a primary outcome
- 5
Verbal Fluency63 studies, 30 as a primary outcome
- 6
Symbol Coding59 studies, 27 as a primary outcome
- 7
Go/No-Go Task44 studies, 17 as a primary outcome
- 8
Delay Discounting36 studies, 16 as a primary outcome
- 9
N-Back Task33 studies, 14 as a primary outcome
- 10
Category Fluency27 studies, 15 as a primary outcome
- 11
Eriksen Flanker Task25 studies, 14 as a primary outcome
- 12
Stop-Signal Task24 studies, 4 as a primary outcome
- 13
Matrix Reasoning19 studies, 6 as a primary outcome
- 14
Dimensional Change Card Sort18 studies, 7 as a primary outcome
- 15
Size Order Memory Test17 studies, 6 as a primary outcome
- 16
Short Story Recall16 studies, 7 as a primary outcome
- 17
Psychomotor Vigilance Task16 studies, 2 as a primary outcome
- 18
Continuous Performance Test15 studies, 8 as a primary outcome
- 19
Picture Naming Test14 studies, 5 as a primary outcome
- 20
Task Switching Test13 studies, 6 as a primary outcome
- 21
Choice Reaction Time13 studies, 2 as a primary outcome
- 22
Complex Figure Copy and Recall12 studies, 7 as a primary outcome
- 23
Paired Associate Learning12 studies, 4 as a primary outcome
- 24
Rapid Visual Information Processing12 studies, 4 as a primary outcome
- 25
Clock Drawing Task11 studies, 6 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
26% of obesity and diabetes studies name only instruments outside the library, such as clinician-administered screening scales. They count in every figure on this page and are not listed. The explorer below holds all 100 tests.
Tests used together
- Stroop Color-Word Test and Trail Making Test42 studies name both
- Trail Making Test and Verbal Learning40 studies name both
- Trail Making Test and Verbal Fluency34 studies name both
- Verbal Fluency and Verbal Learning31 studies name both
- Digit Span Test and Verbal Learning30 studies name both
- Stroop Color-Word Test and Verbal Learning28 studies name both
- Symbol Coding and Trail Making Test26 studies name both
- Digit Span Test and Trail Making Test25 studies name both
- Symbol Coding and Verbal Learning22 studies name both
- Stroop Color-Word Test and Verbal Fluency20 studies name both
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 2 | 0 |
| 2003 | 0 | 0 |
| 2004 | 1 | 0 |
| 2005 | 1 | 1 |
| 2006 | 2 | 0 |
| 2007 | 5 | 1 |
| 2008 | 7 | 5 |
| 2009 | 8 | 1 |
| 2010 | 9 | 2 |
| 2011 | 13 | 4 |
| 2012 | 10 | 3 |
| 2013 | 14 | 7 |
| 2014 | 16 | 4 |
| 2015 | 31 | 9 |
| 2016 | 28 | 10 |
| 2017 | 26 | 10 |
| 2018 | 46 | 19 |
| 2019 | 53 | 18 |
| 2020 | 27 | 9 |
| 2021 | 40 | 14 |
| 2022 | 55 | 23 |
| 2023 | 43 | 19 |
| 2024 | 65 | 19 |
| 2025 | 64 | 29 |
| 2026 | 55 | 18 |
Phases and sponsors
By phase
- Early phase 18 studies, 3 as a primary outcome
- Phase 114 studies, 7 as a primary outcome
- Phase 1/25 studies, 2 as a primary outcome
- Phase 235 studies, 14 as a primary outcome
- Phase 2/36 studies, 1 as a primary outcome
- Phase 312 studies, 3 as a primary outcome
- Phase 430 studies, 10 as a primary outcome
- Not applicable397 studies, 132 as a primary outcome
- Observational120 studies, 56 as a primary outcome
Sponsors and study types
Lead sponsor: industry 25, NIH 9, universities, hospitals and others 593. Interventional 507, observational 120.
Status, results, interventions and countries
Status
- Recruiting117 studies, 42 as a primary outcome
- Not yet recruiting43 studies, 15 as a primary outcome
- Active, not recruiting40 studies, 13 as a primary outcome
- Completed320 studies, 123 as a primary outcome
- Stopped early38 studies, 11 as a primary outcome
- Status unknown69 studies, 24 as a primary outcome
What they test
- Behavioral210 studies, 77 as a primary outcome
- Drug115 studies, 40 as a primary outcome
- Device56 studies, 15 as a primary outcome
- Dietary supplement61 studies, 22 as a primary outcome
- Procedure26 studies, 7 as a primary outcome
- Diagnostic test9 studies, 3 as a primary outcome
- Biological9 studies, 3 as a primary outcome
- Radiation1 studies, 0 as a primary outcome
- Combination product1 studies, 0 as a primary outcome
- Genetic2 studies, 0 as a primary outcome
- Other187 studies, 76 as a primary outcome
- None given64 studies, 29 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States250 studies, 95 as a primary outcome
- China45 studies, 16 as a primary outcome
- Canada32 studies, 6 as a primary outcome
- United Kingdom29 studies, 8 as a primary outcome
- Denmark28 studies, 8 as a primary outcome
- Spain26 studies, 13 as a primary outcome
- Türkiye24 studies, 10 as a primary outcome
- Germany22 studies, 3 as a primary outcome
- Italy20 studies, 5 as a primary outcome
- France14 studies, 7 as a primary outcome
- Netherlands14 studies, 1 as a primary outcome
- Brazil10 studies, 2 as a primary outcome
66 countries in all. A study with sites in several counts in each; 38 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed obesity and diabetes studies: 161 of 320, 50%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed obesity and diabetes studies | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 36, 11% | 776, 10% |
| Results on ClinicalTrials.gov only | 35, 11% | 1,139, 14% |
| A results paper only | 90, 28% | 1,711, 22% |
| Neither | 159, 50% | 4,327, 54% |
How many participants they enroll
- Phase 141 median, 22 to 60
- Phase 257 median, 29 to 105
- Phase 3306 median, 82 to 1,737
- Phase 4100 median, 60 to 192
- Not applicable61 median, 37 to 126
- Observational163 median, 80 to 450
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Phase 1 | 13 | 41 | 22 to 60 |
| Phase 2 | 34 | 57 | 29 to 105 |
| Phase 3 | 12 | 306 | 82 to 1,737 |
| Phase 4 | 30 | 100 | 60 to 192 |
| Not applicable | 390 | 61 | 37 to 126 |
| Observational | 120 | 163 | 80 to 450 |
When the cognitive outcome is measured
Latest time point of each outcome
- Within a day179 outcomes, 73 as a primary outcome
- Up to 4 weeks115 outcomes, 34 as a primary outcome
- 1 to 3 months243 outcomes, 101 as a primary outcome
- 3 to 6 months210 outcomes, 63 as a primary outcome
- 6 to 12 months120 outcomes, 57 as a primary outcome
- 1 to 2 years56 outcomes, 20 as a primary outcome
- Over 2 years94 outcomes, 36 as a primary outcome
- No duration given64 outcomes, 30 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
1,017 of the 1,081 outcome measures give a duration. A single visit counts as within a day.
Median time to the primary outcome, by test
| Test | Primary outcomes | Median |
|---|---|---|
| Trail Making Test | 33 | 4 months |
| Stroop Color-Word Test | 32 | 13 weeks |
| Verbal Fluency | 27 | 6 months |
| Symbol Coding | 25 | 12 weeks |
| Digit Span Test | 24 | 7 weeks |
| Verbal Learning | 24 | 6 months |
| Go/No-Go Task | 17 | 4 weeks |
| Delay Discounting | 16 | 8 weeks |
| Category Fluency | 15 | 12 months |
| N-Back Task | 13 | 16 weeks |
Explore the obesity and diabetes studies
467 studies match. 183 name a library test in a primary outcome. Median size 70 participants. Median time to the primary outcome: 13 weeks.
Loading 467 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 2 that started before 2000 and 3 planned to start after 2026.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 1 | 0 |
| 2003 | 0 | 0 |
| 2004 | 1 | 0 |
| 2005 | 1 | 1 |
| 2006 | 2 | 0 |
| 2007 | 3 | 1 |
| 2008 | 5 | 4 |
| 2009 | 8 | 1 |
| 2010 | 7 | 2 |
| 2011 | 10 | 4 |
| 2012 | 8 | 2 |
| 2013 | 13 | 7 |
| 2014 | 14 | 4 |
| 2015 | 24 | 8 |
| 2016 | 21 | 9 |
| 2017 | 21 | 8 |
| 2018 | 38 | 18 |
| 2019 | 43 | 16 |
| 2020 | 15 | 6 |
| 2021 | 30 | 12 |
| 2022 | 37 | 15 |
| 2023 | 34 | 14 |
| 2024 | 47 | 16 |
| 2025 | 42 | 20 |
| 2026 | 37 | 12 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 15, NIH 8, other 444. Interventional 389, observational 78.
As a primary outcomeSecondary or other outcome
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07883031 | Start2025 | PhaseNot applicable | ConditionsObesity and diabetes | Participants25 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07872904 | Start2026 | PhasePhase 4 | ConditionsObesity and diabetes | Participants400 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07870291 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants105 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07862452 | Start2027 | PhaseNot applicable | ConditionsObesity and diabetes, Cardiovascular disease | Participants400 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07846865 | Start2026 | PhasePhase 2/3 | ConditionsObesity and diabetes, Sleep and sleep disorders | Participants256 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07820774 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants54 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07809295 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants900 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07796932 | Start2027 | PhaseObservational | ConditionsObesity and diabetes | Participants150 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07756177 | Start2023 | PhaseObservational | ConditionsObesity and diabetes | Participants200 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07752225 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants34 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07750223 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants105 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07732426 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes, Substance use and addiction | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07714096 | Start2027 | PhaseNot applicable | ConditionsObesity and diabetes, Cardiovascular disease | Participants56 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07711834 | Start2025 | PhaseNot applicable | ConditionsObesity and diabetes | Participants45 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07705724 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants40 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07704229 | Start2026 | PhaseObservational | ConditionsObesity and diabetes | Participants150 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07694596 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants200 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07688564 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes, Pain and fatigue | Participants156 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07675499 | Start2026 | PhasePhase 2/3 | ConditionsObesity and diabetes | Participants60 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07650318 | Start2026 | PhaseNot applicable | ConditionsMild cognitive impairment, Obesity and diabetes | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07642518 | Start2026 | PhaseNot applicable | ConditionsMild cognitive impairment, Obesity and diabetes | Participants38 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07611201 | Start2025 | PhaseObservational | ConditionsObesity and diabetes | Participants90 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07600567 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants300 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07592728 | Start2026 | PhaseNot applicable | ConditionsObesity and diabetes | Participants36 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07592546 | Start2026 | PhasePhase 4 | ConditionsObesity and diabetes | Participants240 | Lead sponsorOther | StatusRecruiting | Library tests named
|
Questions, answered from the data
Which cognitive test do obesity and diabetes trials use most?
The Stroop Color-Word Test: 103 of the 627 registered studies name it in an outcome measure, 16%. Next come the Trail Making Test (102) and Verbal Learning (74).
Which cognitive test do obesity and diabetes trials use most as a primary outcome?
The Trail Making Test, named in a primary outcome by 35 studies. 228 of the 627 studies, 36%, name a cognitive test in a primary outcome.
How many participants does a phase 2 obesity and diabetes trial enroll?
Half of the phase 2 obesity and diabetes studies enroll 57 participants or fewer, and the middle half enroll 29 to 105. 34 of them give a size.
How long after the start do obesity and diabetes trials measure a cognitive outcome?
Half of the primary outcomes that name a library test are measured within 13 weeks of the start, and the middle half from 4 weeks to 12 months. 384 primary outcomes give a duration.
Which cognitive tests do obesity and diabetes trials use together?
The Stroop Color-Word Test with the Trail Making Test most often: 42 studies name both. Next, the Trail Making Test with Verbal Learning (40).
How many completed obesity and diabetes trials have reported results?
161 of the 320 completed obesity and diabetes studies, 50%, have reported results: 71 posted them on ClinicalTrials.gov, 126 have a results paper linked to the registry record, and 36 did both. The other 159 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Plan the cognitive outcomes of a obesity and diabetes trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.