Clinical trials data

Trail Making Test in dementia and Alzheimer's trials: 273 registered studies

Every registered dementia and Alzheimer's disease study on ClinicalTrials.gov that names the Trail Making Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.

Registered dementia and Alzheimer's disease studies name it in an outcome measure: 273
Name it in a primary outcome, 30%: 83 of 273
Of the condition's 1,673 studies name it, against 14% of all registered studies: 16%; Other conditions
Median participants per study: 72; By phase

Try Trail Making Test A Try Trail Making Test B

Tests named in the same studies

The library tests that dementia and Alzheimer's disease studies naming the Trail Making Test name most often beside it.

1
Digit Span Test104 studies, 37 as a primary outcome
2
Verbal Fluency101 studies, 38 as a primary outcome
3
Verbal Learning99 studies, 47 as a primary outcome
4
Category Fluency71 studies, 27 as a primary outcome
5
Stroop Color-Word Test63 studies, 24 as a primary outcome
6
Symbol Coding51 studies, 22 as a primary outcome
7
Picture Naming Test50 studies, 20 as a primary outcome
8
Complex Figure Copy and Recall38 studies, 18 as a primary outcome
9
Short Story Recall35 studies, 18 as a primary outcome
10
Clock Drawing Task33 studies, 10 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Studies by start year

Each study counted once. 2026 is partly planned starts.

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table

Registered studies by start year
Start year	Studies	A test as a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	1	1
2005	3	1
2006	3	1
2007	3	0
2008	3	1
2009	5	1
2010	9	3
2011	8	4
2012	8	3
2013	13	2
2014	7	0
2015	10	5
2016	8	0
2017	12	4
2018	11	5
2019	22	6
2020	12	5
2021	15	6
2022	26	9
2023	22	3
2024	23	7
2025	32	11
2026	17	5

Phases and study sizes

By phase

Early phase 15 studies, 2 as a primary outcome
Phase 14 studies, 1 as a primary outcome
Phase 1/29 studies, 2 as a primary outcome
Phase 238 studies, 10 as a primary outcome
Phase 2/35 studies, 0 as a primary outcome
Phase 311 studies, 2 as a primary outcome
Phase 413 studies, 2 as a primary outcome
Not applicable156 studies, 53 as a primary outcome
Observational32 studies, 11 as a primary outcome

Participants per study

Phase 255 median, 32 to 80
Phase 3390 median, 220 to 1,107
Phase 4160 median, 92 to 257
Not applicable61 median, 34 to 141
Observational250 median, 116 to 713

Participants per study. The bar spans the middle half of the studies in each phase, the mark is the median, and the axis is logarithmic. Phases with fewer than 10 studies that give a size are left out.

Show as a table

Participants per dementia and Alzheimer's disease study that names the Trail Making Test, by phase
Phase	Studies with a size	Median	Middle half
Phase 2	37	55	32 to 80
Phase 3	11	390	220 to 1,107
Phase 4	12	160	92 to 257
Not applicable	154	61	34 to 141
Observational	30	250	116 to 713

When dementia and Alzheimer's trials measure it

Half of the primary outcomes that name the Trail Making Test are measured within 4 months of the start, and the middle half from 8 weeks to 12 months. 77 primary outcomes give a duration.

Latest time point of each outcome

Within a day14 outcomes, 8 as a primary outcome
Up to 4 weeks19 outcomes, 5 as a primary outcome
1 to 3 months66 outcomes, 22 as a primary outcome
3 to 6 months55 outcomes, 16 as a primary outcome
6 to 12 months61 outcomes, 13 as a primary outcome
1 to 2 years25 outcomes, 6 as a primary outcome
Over 2 years23 outcomes, 7 as a primary outcome
No duration given10 outcomes, 6 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

263 of the 273 outcome measures give a duration. A single visit counts as within a day.

Status, results, interventions and countries

Status

Recruiting55 studies, 18 as a primary outcome
Not yet recruiting16 studies, 4 as a primary outcome
Active, not recruiting14 studies, 5 as a primary outcome
Completed122 studies, 36 as a primary outcome
Stopped early21 studies, 6 as a primary outcome
Status unknown45 studies, 14 as a primary outcome

What they test

Behavioral68 studies, 31 as a primary outcome
Drug74 studies, 18 as a primary outcome
Device57 studies, 14 as a primary outcome
Dietary supplement12 studies, 2 as a primary outcome
Procedure10 studies, 3 as a primary outcome
Diagnostic test4 studies, 2 as a primary outcome
Biological6 studies, 0 as a primary outcome
Radiation2 studies, 1 as a primary outcome
Combination product1 studies, 1 as a primary outcome
Genetic1 studies, 1 as a primary outcome
Other66 studies, 21 as a primary outcome
None given19 studies, 7 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

36 countries in all. A study with sites in several counts in each; 16 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed dementia and Alzheimer's disease studies that name the Trail Making Test: 73 of 122, 60%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed dementia and Alzheimer's disease studies that name the Trail Making Test and every completed study, by how they reported results
Results	Completed dementia and Alzheimer's disease studies that name the Trail Making Test	Every completed study
Results on ClinicalTrials.gov and a paper	23, 19%	776, 10%
Results on ClinicalTrials.gov only	16, 13%	1,139, 14%
A results paper only	34, 28%	1,711, 22%
Neither	49, 40%	4,327, 54%

The 273 studies

Filter by phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.

273 studies match. 83 name the Trail Making Test in a primary outcome. Median size 72 participants. Median time to the primary outcome: 4 months.

Loading 273 studies; the filters turn on when they arrive.

By start year

2026 is partly planned starts.

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Matching studies by start year
Start year	Studies	As a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	1	1
2005	3	1
2006	3	1
2007	3	0
2008	3	1
2009	5	1
2010	9	3
2011	8	4
2012	8	3
2013	13	2
2014	7	0
2015	10	5
2016	8	0
2017	12	4
2018	11	5
2019	22	6
2020	12	5
2021	15	6
2022	26	9
2023	22	3
2024	23	7
2025	32	11
2026	17	5

Library tests named most

Largest condition groups

Dementia and Alzheimer's273 studies, 83 as a primary outcome
Mild cognitive impairment71 studies, 21 as a primary outcome
Aging, frailty and exercise22 studies, 7 as a primary outcome
Healthy volunteers9 studies, 6 as a primary outcome
Parkinson's disease8 studies, 4 as a primary outcome
Obesity and diabetes8 studies, 4 as a primary outcome
Depression and bipolar disorder6 studies, 1 as a primary outcome
Cardiovascular disease6 studies, 0 as a primary outcome
Cancer5 studies, 1 as a primary outcome
Sleep and sleep disorders5 studies, 1 as a primary outcome
Delirium, surgery and intensive care5 studies, 2 as a primary outcome
Stroke4 studies, 1 as a primary outcome

Phases

Participants

Lead sponsor: industry 33, other 240. Interventional 241, observational 32.

As a primary outcomeSecondary or other outcomeThe Trail Making Test

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
Study	Start	Phase	Conditions	Participants	Lead sponsor	Status	Library tests named, with the latest time point
NCT07883148	Start2024	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants52	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary8 months Verbal LearningSecondary8 months Verbal FluencySecondary8 months Digit Span TestSecondary8 months Complex Figure Copy and RecallSecondary8 months
NCT07856043	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Cardiovascular disease	Participants18	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary12 weeks Symbol CodingSecondary12 weeks Selective Reminding TaskSecondary12 weeks
NCT07841145	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants68	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary13 weeks Verbal FluencySecondary13 weeks
NCT07839650	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants30	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Category FluencyPrimary6 months Task Switching TestPrimary6 months Face-name Memory TaskPrimary6 months
NCT07741071	Start2026	PhasePhase 2	ConditionsDementia and Alzheimer's	Participants270	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary2 years Verbal FluencySecondary2 years
NCT07731334	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants384	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months Verbal LearningSecondary12 months Verbal FluencySecondary12 months Digit Span TestSecondary12 months Complex Figure Copy and RecallSecondary12 months Corsi Block-Tapping TestSecondary12 months Oddball Target DetectionSecondary
NCT07717411	Start2026	PhasePhase 3	ConditionsDementia and Alzheimer's	Participants1,600	Lead sponsorIndustry	StatusRecruiting	Library tests named Trail Making TestSecondary4 years Symbol CodingSecondary4 years Category FluencySecondary4 years Short Story RecallSecondary4 years Selective Reminding TaskSecondary4 years
NCT07700615	Start2025	PhasePhase 4	ConditionsDementia and Alzheimer's	Participants120	Lead sponsorIndustry	StatusCompleted	Library tests named Trail Making TestSecondary9 weeks Symbol CodingSecondary9 weeks
NCT07692542	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary2 weeks Stroop Color-Word TestSecondary2 weeks
NCT07667478	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months
NCT07646054	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants1,200	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months
NCT07645638	Start2025	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants33	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary Verbal FluencySecondary
NCT07642726	Start2018	PhaseObservational	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants276	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestPrimary12 months Verbal FluencySecondary12 months Delayed Recall ModuleSecondary12 months
NCT07629349	Start2020	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants600	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Block Copy TestPrimary6 months
NCT07505784	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants30	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary Verbal FluencyPrimary Digit Span TestPrimary Go/No-Go TaskPrimary Category FluencyPrimary Task Switching TestPrimary Emoji Emotion RecognitionPrimary
NCT07413744	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestOther outcome8 months Task Switching TestOther outcome8 months
NCT07402356	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Depression and bipolar disorder	Participants140	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Verbal LearningSecondary6 months Verbal FluencySecondary6 months N-Back TaskPrimarysame day Category FluencySecondary6 months Picture Naming TestSecondary6 months
NCT07399418	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's	Participants80	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimarysame day Stroop Color-Word TestPrimarysame day Verbal FluencyPrimarysame day Digit Span TestPrimarysame day Go/No-Go TaskPrimarysame day Category FluencyPrimarysame day Clock Drawing TaskPrimarysame day Complex Figure Copy and RecallPrimarysame day Matrix ReasoningPrimarysame day Selective Reminding TaskPrimarysame day
NCT07392944	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants60	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary4 months Symbol CodingSecondary4 months
NCT07392723	Start2025	PhasePhase 2	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants20	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Digit Span TestSecondary6 months Category FluencySecondary6 months Delayed Recall ModuleSecondary6 months
NCT07385937	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants150	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary18 months Verbal FluencySecondary18 months Digit Span TestSecondary18 months Category FluencySecondary18 months Clock Drawing TaskSecondary18 months Cancellation TestSecondary18 months Delayed Recall ModuleSecondary18 months
NCT07376135	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants300	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestOther outcome18 months Stroop Color-Word TestOther outcome18 months Verbal LearningOther outcome18 months Digit Span TestOther outcome18 months Symbol CodingOther outcome18 months Short Story RecallOther outcome18 months Complex Figure Copy and RecallOther outcome18 months
NCT07375771	Start2025	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary12 weeks Verbal LearningPrimary12 weeks Verbal FluencyPrimary12 weeks Digit Span TestPrimary12 weeks Category FluencyPrimary12 weeks Task Switching TestPrimary12 weeks Clock Drawing TaskPrimary12 weeks Complex Figure Copy and RecallPrimary12 weeks Visual Search TestPrimary12 weeks
NCT07366346	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants100	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary5 months Verbal LearningPrimary5 months Verbal FluencyPrimary5 months Category FluencyPrimary5 months
NCT07272863	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise, Sleep and sleep disorders	Participants214	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary12 months Verbal FluencyPrimary12 months

Questions, answered from the data

How many dementia and Alzheimer's trials use the Trail Making Test?

273 registered dementia and Alzheimer's disease studies on ClinicalTrials.gov name it in an outcome measure, 83 of them in a primary outcome: 16% of the condition's 1,673 studies with a cognitive outcome, against 14% of all of them. It is the test dementia and Alzheimer's trials name most.

Which tests do dementia and Alzheimer's trials use with the Trail Making Test?

The Digit Span Test (104 studies), Verbal Fluency (101 studies) and Verbal Learning (99 studies).

How many participants do phase 2 dementia and Alzheimer's trials that use the Trail Making Test enroll?

Half of the phase 2 studies that name it enroll 55 participants or fewer, and the middle half enroll 32 to 80. 37 of them give a size.

When do dementia and Alzheimer's trials measure the Trail Making Test?

Half of the primary outcomes that name the Trail Making Test are measured within 4 months of the start, and the middle half from 8 weeks to 12 months. 77 primary outcomes give a duration.

How many completed dementia and Alzheimer's trials that use the Trail Making Test have reported results?

73 of the 122 completed studies that name it, 60%, have reported results: 39 posted them on ClinicalTrials.gov, 57 have a results paper linked to the registry record, and 23 did both. The other 49 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.

How the studies are counted

For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.

The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.

A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.

A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.

The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.

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Clinical trials data

Trail Making Test in dementia and Alzheimer's trials: 273 registered studies

Registered dementia and Alzheimer's disease studies name it in an outcome measure: 273
Name it in a primary outcome, 30%: 83 of 273
Of the condition's 1,673 studies name it, against 14% of all registered studies: 16%; Other conditions
Median participants per study: 72; By phase

Try Trail Making Test A Try Trail Making Test B

Tests named in the same studies

The library tests that dementia and Alzheimer's disease studies naming the Trail Making Test name most often beside it.

1
Digit Span Test104 studies, 37 as a primary outcome
2
Verbal Fluency101 studies, 38 as a primary outcome
3
Verbal Learning99 studies, 47 as a primary outcome
4
Category Fluency71 studies, 27 as a primary outcome
5
Stroop Color-Word Test63 studies, 24 as a primary outcome
6
Symbol Coding51 studies, 22 as a primary outcome
7
Picture Naming Test50 studies, 20 as a primary outcome
8
Complex Figure Copy and Recall38 studies, 18 as a primary outcome
9
Short Story Recall35 studies, 18 as a primary outcome
10
Clock Drawing Task33 studies, 10 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Studies by start year

Each study counted once. 2026 is partly planned starts.

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table

Registered studies by start year
Start year	Studies	A test as a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	1	1
2005	3	1
2006	3	1
2007	3	0
2008	3	1
2009	5	1
2010	9	3
2011	8	4
2012	8	3
2013	13	2
2014	7	0
2015	10	5
2016	8	0
2017	12	4
2018	11	5
2019	22	6
2020	12	5
2021	15	6
2022	26	9
2023	22	3
2024	23	7
2025	32	11
2026	17	5

Phases and study sizes

By phase

Early phase 15 studies, 2 as a primary outcome
Phase 14 studies, 1 as a primary outcome
Phase 1/29 studies, 2 as a primary outcome
Phase 238 studies, 10 as a primary outcome
Phase 2/35 studies, 0 as a primary outcome
Phase 311 studies, 2 as a primary outcome
Phase 413 studies, 2 as a primary outcome
Not applicable156 studies, 53 as a primary outcome
Observational32 studies, 11 as a primary outcome

Participants per study

Phase 255 median, 32 to 80
Phase 3390 median, 220 to 1,107
Phase 4160 median, 92 to 257
Not applicable61 median, 34 to 141
Observational250 median, 116 to 713

Show as a table

Participants per dementia and Alzheimer's disease study that names the Trail Making Test, by phase
Phase	Studies with a size	Median	Middle half
Phase 2	37	55	32 to 80
Phase 3	11	390	220 to 1,107
Phase 4	12	160	92 to 257
Not applicable	154	61	34 to 141
Observational	30	250	116 to 713

When dementia and Alzheimer's trials measure it

Half of the primary outcomes that name the Trail Making Test are measured within 4 months of the start, and the middle half from 8 weeks to 12 months. 77 primary outcomes give a duration.

Latest time point of each outcome

Within a day14 outcomes, 8 as a primary outcome
Up to 4 weeks19 outcomes, 5 as a primary outcome
1 to 3 months66 outcomes, 22 as a primary outcome
3 to 6 months55 outcomes, 16 as a primary outcome
6 to 12 months61 outcomes, 13 as a primary outcome
1 to 2 years25 outcomes, 6 as a primary outcome
Over 2 years23 outcomes, 7 as a primary outcome
No duration given10 outcomes, 6 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

263 of the 273 outcome measures give a duration. A single visit counts as within a day.

Status, results, interventions and countries

Status

Recruiting55 studies, 18 as a primary outcome
Not yet recruiting16 studies, 4 as a primary outcome
Active, not recruiting14 studies, 5 as a primary outcome
Completed122 studies, 36 as a primary outcome
Stopped early21 studies, 6 as a primary outcome
Status unknown45 studies, 14 as a primary outcome

What they test

Behavioral68 studies, 31 as a primary outcome
Drug74 studies, 18 as a primary outcome
Device57 studies, 14 as a primary outcome
Dietary supplement12 studies, 2 as a primary outcome
Procedure10 studies, 3 as a primary outcome
Diagnostic test4 studies, 2 as a primary outcome
Biological6 studies, 0 as a primary outcome
Radiation2 studies, 1 as a primary outcome
Combination product1 studies, 1 as a primary outcome
Genetic1 studies, 1 as a primary outcome
Other66 studies, 21 as a primary outcome
None given19 studies, 7 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

36 countries in all. A study with sites in several counts in each; 16 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed dementia and Alzheimer's disease studies that name the Trail Making Test: 73 of 122, 60%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed dementia and Alzheimer's disease studies that name the Trail Making Test and every completed study, by how they reported results
Results	Completed dementia and Alzheimer's disease studies that name the Trail Making Test	Every completed study
Results on ClinicalTrials.gov and a paper	23, 19%	776, 10%
Results on ClinicalTrials.gov only	16, 13%	1,139, 14%
A results paper only	34, 28%	1,711, 22%
Neither	49, 40%	4,327, 54%

The 273 studies

Filter by phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.

273 studies match. 83 name the Trail Making Test in a primary outcome. Median size 72 participants. Median time to the primary outcome: 4 months.

Loading 273 studies; the filters turn on when they arrive.

By start year

2026 is partly planned starts.

Show as a table

Matching studies by start year
Start year	Studies	As a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	1	1
2005	3	1
2006	3	1
2007	3	0
2008	3	1
2009	5	1
2010	9	3
2011	8	4
2012	8	3
2013	13	2
2014	7	0
2015	10	5
2016	8	0
2017	12	4
2018	11	5
2019	22	6
2020	12	5
2021	15	6
2022	26	9
2023	22	3
2024	23	7
2025	32	11
2026	17	5

Library tests named most

Largest condition groups

Dementia and Alzheimer's273 studies, 83 as a primary outcome
Mild cognitive impairment71 studies, 21 as a primary outcome
Aging, frailty and exercise22 studies, 7 as a primary outcome
Healthy volunteers9 studies, 6 as a primary outcome
Parkinson's disease8 studies, 4 as a primary outcome
Obesity and diabetes8 studies, 4 as a primary outcome
Depression and bipolar disorder6 studies, 1 as a primary outcome
Cardiovascular disease6 studies, 0 as a primary outcome
Cancer5 studies, 1 as a primary outcome
Sleep and sleep disorders5 studies, 1 as a primary outcome
Delirium, surgery and intensive care5 studies, 2 as a primary outcome
Stroke4 studies, 1 as a primary outcome

Phases

Participants

Lead sponsor: industry 33, other 240. Interventional 241, observational 32.

As a primary outcomeSecondary or other outcomeThe Trail Making Test

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
Study	Start	Phase	Conditions	Participants	Lead sponsor	Status	Library tests named, with the latest time point
NCT07883148	Start2024	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants52	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary8 months Verbal LearningSecondary8 months Verbal FluencySecondary8 months Digit Span TestSecondary8 months Complex Figure Copy and RecallSecondary8 months
NCT07856043	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Cardiovascular disease	Participants18	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary12 weeks Symbol CodingSecondary12 weeks Selective Reminding TaskSecondary12 weeks
NCT07841145	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants68	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary13 weeks Verbal FluencySecondary13 weeks
NCT07839650	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants30	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Category FluencyPrimary6 months Task Switching TestPrimary6 months Face-name Memory TaskPrimary6 months
NCT07741071	Start2026	PhasePhase 2	ConditionsDementia and Alzheimer's	Participants270	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary2 years Verbal FluencySecondary2 years
NCT07731334	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants384	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months Verbal LearningSecondary12 months Verbal FluencySecondary12 months Digit Span TestSecondary12 months Complex Figure Copy and RecallSecondary12 months Corsi Block-Tapping TestSecondary12 months Oddball Target DetectionSecondary
NCT07717411	Start2026	PhasePhase 3	ConditionsDementia and Alzheimer's	Participants1,600	Lead sponsorIndustry	StatusRecruiting	Library tests named Trail Making TestSecondary4 years Symbol CodingSecondary4 years Category FluencySecondary4 years Short Story RecallSecondary4 years Selective Reminding TaskSecondary4 years
NCT07700615	Start2025	PhasePhase 4	ConditionsDementia and Alzheimer's	Participants120	Lead sponsorIndustry	StatusCompleted	Library tests named Trail Making TestSecondary9 weeks Symbol CodingSecondary9 weeks
NCT07692542	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary2 weeks Stroop Color-Word TestSecondary2 weeks
NCT07667478	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months
NCT07646054	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants1,200	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months
NCT07645638	Start2025	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants33	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary Verbal FluencySecondary
NCT07642726	Start2018	PhaseObservational	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants276	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestPrimary12 months Verbal FluencySecondary12 months Delayed Recall ModuleSecondary12 months
NCT07629349	Start2020	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants600	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Block Copy TestPrimary6 months
NCT07505784	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants30	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary Verbal FluencyPrimary Digit Span TestPrimary Go/No-Go TaskPrimary Category FluencyPrimary Task Switching TestPrimary Emoji Emotion RecognitionPrimary
NCT07413744	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestOther outcome8 months Task Switching TestOther outcome8 months
NCT07402356	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Depression and bipolar disorder	Participants140	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Verbal LearningSecondary6 months Verbal FluencySecondary6 months N-Back TaskPrimarysame day Category FluencySecondary6 months Picture Naming TestSecondary6 months
NCT07399418	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's	Participants80	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimarysame day Stroop Color-Word TestPrimarysame day Verbal FluencyPrimarysame day Digit Span TestPrimarysame day Go/No-Go TaskPrimarysame day Category FluencyPrimarysame day Clock Drawing TaskPrimarysame day Complex Figure Copy and RecallPrimarysame day Matrix ReasoningPrimarysame day Selective Reminding TaskPrimarysame day
NCT07392944	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants60	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary4 months Symbol CodingSecondary4 months
NCT07392723	Start2025	PhasePhase 2	ConditionsDementia and Alzheimer's, Aging, frailty and exercise	Participants20	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Digit Span TestSecondary6 months Category FluencySecondary6 months Delayed Recall ModuleSecondary6 months
NCT07385937	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants150	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary18 months Verbal FluencySecondary18 months Digit Span TestSecondary18 months Category FluencySecondary18 months Clock Drawing TaskSecondary18 months Cancellation TestSecondary18 months Delayed Recall ModuleSecondary18 months
NCT07376135	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants300	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestOther outcome18 months Stroop Color-Word TestOther outcome18 months Verbal LearningOther outcome18 months Digit Span TestOther outcome18 months Symbol CodingOther outcome18 months Short Story RecallOther outcome18 months Complex Figure Copy and RecallOther outcome18 months
NCT07375771	Start2025	PhaseNot applicable	ConditionsDementia and Alzheimer's	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary12 weeks Verbal LearningPrimary12 weeks Verbal FluencyPrimary12 weeks Digit Span TestPrimary12 weeks Category FluencyPrimary12 weeks Task Switching TestPrimary12 weeks Clock Drawing TaskPrimary12 weeks Complex Figure Copy and RecallPrimary12 weeks Visual Search TestPrimary12 weeks
NCT07366346	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants100	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary5 months Verbal LearningPrimary5 months Verbal FluencyPrimary5 months Category FluencyPrimary5 months
NCT07272863	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Aging, frailty and exercise, Sleep and sleep disorders	Participants214	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary12 months Verbal FluencyPrimary12 months

Questions, answered from the data

How many dementia and Alzheimer's trials use the Trail Making Test?

Which tests do dementia and Alzheimer's trials use with the Trail Making Test?

The Digit Span Test (104 studies), Verbal Fluency (101 studies) and Verbal Learning (99 studies).

How many participants do phase 2 dementia and Alzheimer's trials that use the Trail Making Test enroll?

Half of the phase 2 studies that name it enroll 55 participants or fewer, and the middle half enroll 32 to 80. 37 of them give a size.

When do dementia and Alzheimer's trials measure the Trail Making Test?

Half of the primary outcomes that name the Trail Making Test are measured within 4 months of the start, and the middle half from 8 weeks to 12 months. 77 primary outcomes give a duration.

How many completed dementia and Alzheimer's trials that use the Trail Making Test have reported results?

How the studies are counted

The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.

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Trail Making Test in dementia and Alzheimer's trials: 273 registered studies

Tests named in the same studies

Studies by start year

Phases and study sizes

By phase

Participants per study

When dementia and Alzheimer's trials measure it

Latest time point of each outcome

Status, results, interventions and countries

Status

What they test

Where their sites are

Reported results

The 273 studies

Library tests named most

Largest condition groups

Phases

Participants

The studies, newest registration first

Questions, answered from the data

How many dementia and Alzheimer's trials use the Trail Making Test?

Which tests do dementia and Alzheimer's trials use with the Trail Making Test?

How many participants do phase 2 dementia and Alzheimer's trials that use the Trail Making Test enroll?

When do dementia and Alzheimer's trials measure the Trail Making Test?

How many completed dementia and Alzheimer's trials that use the Trail Making Test have reported results?

More on the Trail Making Test and dementia and Alzheimer's disease

The Trail Making Test in other conditions

Other tests in dementia and Alzheimer's trials

How the studies are counted

Run the Trail Making Test in your trial

Trail Making Test in dementia and Alzheimer's trials: 273 registered studies

Tests named in the same studies

Studies by start year

Phases and study sizes

By phase

Participants per study

When dementia and Alzheimer's trials measure it

Latest time point of each outcome

Status, results, interventions and countries

Status

What they test

Where their sites are

Reported results

The 273 studies

Library tests named most

Largest condition groups

Phases

Participants

The studies, newest registration first

Questions, answered from the data

How many dementia and Alzheimer's trials use the Trail Making Test?

Which tests do dementia and Alzheimer's trials use with the Trail Making Test?

How many participants do phase 2 dementia and Alzheimer's trials that use the Trail Making Test enroll?

When do dementia and Alzheimer's trials measure the Trail Making Test?

How many completed dementia and Alzheimer's trials that use the Trail Making Test have reported results?

More on the Trail Making Test and dementia and Alzheimer's disease

The Trail Making Test in other conditions

Other tests in dementia and Alzheimer's trials

How the studies are counted

Run the Trail Making Test in your trial