Clinical trials data
Trail Making Test in substance use and addiction trials: 52 registered studies
Every registered substance use and addiction study on ClinicalTrials.gov that names the Trail Making Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.
- Registered substance use and addiction studies name it in an outcome measure
- 52
- Name it in a primary outcome, 29%
- 15 of 52
Tests named in the same studies
- 1
Stroop Color-Word Test15 studies, 5 as a primary outcome
- 2
Verbal Learning15 studies, 5 as a primary outcome
- 3
Continuous Performance Test11 studies, 4 as a primary outcome
- 4
Card Sorting Test (Berg)10 studies, 6 as a primary outcome
- 5
Digit Span Test10 studies, 4 as a primary outcome
- 6
Verbal Fluency8 studies, 3 as a primary outcome
- 7
Stop-Signal Task6 studies, 3 as a primary outcome
- 8
Symbol Coding6 studies, 2 as a primary outcome
- 9
Iowa Gambling Lite5 studies, 3 as a primary outcome
- 10
Go/No-Go Task5 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 1 | 0 |
| 2003 | 0 | 0 |
| 2004 | 1 | 1 |
| 2005 | 0 | 0 |
| 2006 | 2 | 1 |
| 2007 | 1 | 1 |
| 2008 | 0 | 0 |
| 2009 | 1 | 1 |
| 2010 | 3 | 1 |
| 2011 | 1 | 1 |
| 2012 | 1 | 0 |
| 2013 | 1 | 1 |
| 2014 | 1 | 0 |
| 2015 | 2 | 2 |
| 2016 | 0 | 0 |
| 2017 | 2 | 1 |
| 2018 | 3 | 0 |
| 2019 | 2 | 0 |
| 2020 | 5 | 3 |
| 2021 | 6 | 0 |
| 2022 | 2 | 0 |
| 2023 | 5 | 0 |
| 2024 | 7 | 2 |
| 2025 | 2 | 0 |
| 2026 | 3 | 0 |
Phases and study sizes
By phase
- Early phase 13 studies, 0 as a primary outcome
- Phase 11 studies, 1 as a primary outcome
- Phase 1/21 studies, 0 as a primary outcome
- Phase 28 studies, 2 as a primary outcome
- Phase 34 studies, 2 as a primary outcome
- Phase 45 studies, 2 as a primary outcome
- Not applicable25 studies, 6 as a primary outcome
- Observational5 studies, 2 as a primary outcome
Participants per study
- Not applicable56 median, 46 to 116
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Not applicable | 23 | 56 | 46 to 116 |
When substance use and addiction trials measure it
Latest time point of each outcome
- Within a day9 outcomes, 2 as a primary outcome
- Up to 4 weeks12 outcomes, 4 as a primary outcome
- 1 to 3 months15 outcomes, 6 as a primary outcome
- 3 to 6 months7 outcomes, 1 as a primary outcome
- 6 to 12 months1 outcomes, 0 as a primary outcome
- Over 2 years1 outcomes, 1 as a primary outcome
- No duration given7 outcomes, 1 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
45 of the 52 outcome measures give a duration. A single visit counts as within a day.
Status, results, interventions and countries
Status
- Recruiting10 studies, 1 as a primary outcome
- Active, not recruiting2 studies, 0 as a primary outcome
- Completed25 studies, 13 as a primary outcome
- Stopped early7 studies, 0 as a primary outcome
- Status unknown8 studies, 1 as a primary outcome
What they test
- Behavioral12 studies, 3 as a primary outcome
- Drug21 studies, 7 as a primary outcome
- Device7 studies, 1 as a primary outcome
- Dietary supplement3 studies, 0 as a primary outcome
- Procedure2 studies, 0 as a primary outcome
- Diagnostic test2 studies, 1 as a primary outcome
- Other5 studies, 2 as a primary outcome
- None given3 studies, 1 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States18 studies, 8 as a primary outcome
- Canada8 studies, 1 as a primary outcome
- France6 studies, 2 as a primary outcome
- Australia3 studies, 0 as a primary outcome
- Brazil2 studies, 1 as a primary outcome
- Türkiye2 studies, 1 as a primary outcome
- Belgium1 studies, 0 as a primary outcome
- Chile1 studies, 0 as a primary outcome
- China1 studies, 1 as a primary outcome
- Czechia1 studies, 1 as a primary outcome
- Denmark1 studies, 0 as a primary outcome
- Hong Kong1 studies, 0 as a primary outcome
16 countries in all. A study with sites in several counts in each; 4 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed substance use and addiction studies that name the Trail Making Test: 13 of 25, 52%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed substance use and addiction studies that name the Trail Making Test | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 4, 16% | 776, 10% |
| Results on ClinicalTrials.gov only | 4, 16% | 1,139, 14% |
| A results paper only | 5, 20% | 1,711, 22% |
| Neither | 12, 48% | 4,327, 54% |
The 52 studies
52 studies match. 15 name the Trail Making Test in a primary outcome. Median size 56 participants. Median time to the primary outcome: 7 weeks.
Loading 52 studies; the filters turn on when they arrive.
2026 is partly planned starts.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 1 | 0 |
| 2003 | 0 | 0 |
| 2004 | 1 | 1 |
| 2005 | 0 | 0 |
| 2006 | 2 | 1 |
| 2007 | 1 | 1 |
| 2008 | 0 | 0 |
| 2009 | 1 | 1 |
| 2010 | 3 | 1 |
| 2011 | 1 | 1 |
| 2012 | 1 | 0 |
| 2013 | 1 | 1 |
| 2014 | 1 | 0 |
| 2015 | 2 | 2 |
| 2016 | 0 | 0 |
| 2017 | 2 | 1 |
| 2018 | 3 | 0 |
| 2019 | 2 | 0 |
| 2020 | 5 | 3 |
| 2021 | 6 | 0 |
| 2022 | 2 | 0 |
| 2023 | 5 | 0 |
| 2024 | 7 | 2 |
| 2025 | 2 | 0 |
| 2026 | 3 | 0 |
Library tests named most
Conditions
Phases
Participants
Lead sponsor: industry 1, other 51. Interventional 47, observational 5.
As a primary outcomeSecondary or other outcomeThe Trail Making Test
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07633392 | Start2026 | PhaseNot applicable | ConditionsAging, frailty and exercise, Substance use and addiction, Sleep and sleep disorders, Cardiovascular disease | Participants240 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07464613 | Start2026 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants60 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07160153 | Start2024 | PhaseObservational | ConditionsSubstance use and addiction | Participants29 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07056894 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Substance use and addiction | Participants50 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07001878 | Start2025 | PhasePhase 4 | ConditionsSchizophrenia and psychosis, Substance use and addiction | Participants24 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06933186 | Start2024 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants48 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT06899594 | Start2025 | PhaseEarly phase 1 | ConditionsSubstance use and addiction | Participants20 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06636929 | Start2024 | PhaseObservational | ConditionsSubstance use and addiction | Participants131 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06505239 | Start2024 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants26 | Lead sponsorIndustry | StatusCompleted | Library tests named
|
| NCT06387719 | Start2023 | PhaseObservational | ConditionsObesity and diabetes, Substance use and addiction | Participants102 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06380985 | Start2024 | PhaseNot applicable | ConditionsBrain injury and concussion, Substance use and addiction | ParticipantsNot given | Lead sponsorOther | StatusStopped early | Library tests named
|
| NCT06244329 | Start2020 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants48 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06030362 | Start2023 | PhaseNot applicable | ConditionsObesity and diabetes, Substance use and addiction | Participants106 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT05859347 | Start2023 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants46 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05596058 | Start2022 | PhaseNot applicable | ConditionsSubstance use and addiction, Pain and fatigue | Participants30 | Lead sponsorOther | StatusStopped early | Library tests named
|
| NCT05568251 | Start2019 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants38 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT05408247 | Start2023 | PhasePhase 4 | ConditionsSubstance use and addiction | Participants280 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05387148 | Start2022 | PhasePhase 2 | ConditionsSubstance use and addiction | Participants20 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT04997330 | Start2021 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants95 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT04964843 | Start2023 | PhasePhase 2 | ConditionsSubstance use and addiction | ParticipantsNot given | Lead sponsorOther | StatusStopped early | Library tests named
|
| NCT04935619 | Start2021 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Substance use and addiction, Anxiety, PTSD and OCD | Participants52 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT04822987 | Start2021 | PhaseObservational | ConditionsSubstance use and addiction | Participants120 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT04647422 | Start2020 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants216 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT04574167 | Start2020 | PhaseNot applicable | ConditionsSubstance use and addiction | Participants45 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT04569760 | Start2021 | PhasePhase 3 | ConditionsSubstance use and addiction, Anxiety, PTSD and OCD | ParticipantsNot given | Lead sponsorOther | StatusStopped early | Library tests named
|
Questions, answered from the data
How many substance use and addiction trials use the Trail Making Test?
52 registered substance use and addiction studies on ClinicalTrials.gov name it in an outcome measure, 15 of them in a primary outcome: 6% of the condition's 895 studies with a cognitive outcome, against 14% of all of them. It is the 11th most named test in substance use and addiction trials.
Which tests do substance use and addiction trials use with the Trail Making Test?
The Stroop Color-Word Test (15 studies), Verbal Learning (15 studies) and the Continuous Performance Test (11 studies).
When do substance use and addiction trials measure the Trail Making Test?
Half of the primary outcomes that name the Trail Making Test are measured within 7 weeks of the start, and the middle half from 3 weeks to 9 weeks. 14 primary outcomes give a duration.
How many completed substance use and addiction trials that use the Trail Making Test have reported results?
13 of the 25 completed studies that name it, 52%, have reported results: 8 posted them on ClinicalTrials.gov, 9 have a results paper linked to the registry record, and 4 did both. The other 12 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.
Run the Trail Making Test in your trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.