Clinical trials data

Trail Making Test in mild cognitive impairment trials: 213 registered studies

Every registered mild cognitive impairment study on ClinicalTrials.gov that names the Trail Making Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.

Registered mild cognitive impairment studies name it in an outcome measure: 213
Name it in a primary outcome, 38%: 82 of 213
Of the condition's 859 studies name it, against 14% of all registered studies: 25%; Other conditions
Median participants per study: 70; By phase

Try Trail Making Test A Try Trail Making Test B

Tests named in the same studies

The library tests that mild cognitive impairment studies naming the Trail Making Test name most often beside it.

1
Digit Span Test95 studies, 34 as a primary outcome
2
Verbal Fluency86 studies, 28 as a primary outcome
3
Verbal Learning84 studies, 44 as a primary outcome
4
Stroop Color-Word Test64 studies, 22 as a primary outcome
5
Category Fluency51 studies, 23 as a primary outcome
6
Symbol Coding42 studies, 22 as a primary outcome
7
Picture Naming Test41 studies, 11 as a primary outcome
8
Short Story Recall29 studies, 14 as a primary outcome
9
Complex Figure Copy and Recall22 studies, 9 as a primary outcome
10
Clock Drawing Task21 studies, 8 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Studies by start year

Each study counted once. 2026 is partly planned starts.

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table

Registered studies by start year
Start year	Studies	A test as a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	0	0
2005	0	0
2006	1	0
2007	0	0
2008	1	1
2009	1	1
2010	5	3
2011	4	1
2012	5	1
2013	2	0
2014	2	1
2015	6	2
2016	11	3
2017	9	4
2018	6	4
2019	13	5
2020	18	8
2021	19	9
2022	16	5
2023	26	7
2024	23	14
2025	22	5
2026	23	8

Phases and study sizes

By phase

Early phase 14 studies, 2 as a primary outcome
Phase 11 studies, 0 as a primary outcome
Phase 220 studies, 7 as a primary outcome
Phase 2/31 studies, 0 as a primary outcome
Phase 32 studies, 1 as a primary outcome
Phase 45 studies, 1 as a primary outcome
Not applicable165 studies, 67 as a primary outcome
Observational15 studies, 4 as a primary outcome

Participants per study

Phase 278 median, 54 to 142
Not applicable62 median, 38 to 128
Observational140 median, 80 to 425

Participants per study. The bar spans the middle half of the studies in each phase, the mark is the median, and the axis is logarithmic. Phases with fewer than 10 studies that give a size are left out.

Show as a table

Participants per mild cognitive impairment study that names the Trail Making Test, by phase
Phase	Studies with a size	Median	Middle half
Phase 2	19	78	54 to 142
Not applicable	165	62	38 to 128
Observational	15	140	80 to 425

When mild cognitive impairment trials measure it

Half of the primary outcomes that name the Trail Making Test are measured within 13 weeks of the start, and the middle half from 8 weeks to 7 months. 75 primary outcomes give a duration.

Latest time point of each outcome

Within a day11 outcomes, 5 as a primary outcome
Up to 4 weeks17 outcomes, 4 as a primary outcome
1 to 3 months57 outcomes, 31 as a primary outcome
3 to 6 months44 outcomes, 16 as a primary outcome
6 to 12 months43 outcomes, 9 as a primary outcome
1 to 2 years18 outcomes, 9 as a primary outcome
Over 2 years9 outcomes, 1 as a primary outcome
No duration given14 outcomes, 7 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

199 of the 213 outcome measures give a duration. A single visit counts as within a day.

Status, results, interventions and countries

Status

Recruiting48 studies, 18 as a primary outcome
Not yet recruiting15 studies, 3 as a primary outcome
Active, not recruiting6 studies, 4 as a primary outcome
Completed98 studies, 39 as a primary outcome
Stopped early5 studies, 2 as a primary outcome
Status unknown41 studies, 16 as a primary outcome

What they test

Behavioral78 studies, 34 as a primary outcome
Drug27 studies, 9 as a primary outcome
Device46 studies, 10 as a primary outcome
Dietary supplement15 studies, 4 as a primary outcome
Procedure6 studies, 1 as a primary outcome
Diagnostic test3 studies, 2 as a primary outcome
Biological2 studies, 0 as a primary outcome
Radiation1 studies, 0 as a primary outcome
Combination product4 studies, 2 as a primary outcome
Other63 studies, 30 as a primary outcome
None given9 studies, 3 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

35 countries in all. A study with sites in several counts in each; 11 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed mild cognitive impairment studies that name the Trail Making Test: 46 of 98, 47%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed mild cognitive impairment studies that name the Trail Making Test and every completed study, by how they reported results
Results	Completed mild cognitive impairment studies that name the Trail Making Test	Every completed study
Results on ClinicalTrials.gov and a paper	16, 16%	776, 10%
Results on ClinicalTrials.gov only	12, 12%	1,139, 14%
A results paper only	18, 18%	1,711, 22%
Neither	52, 53%	4,327, 54%

The 213 studies

Filter by phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.

213 studies match. 82 name the Trail Making Test in a primary outcome. Median size 70 participants. Median time to the primary outcome: 13 weeks.

Loading 213 studies; the filters turn on when they arrive.

By start year

2026 is partly planned starts.

Show as a table

Matching studies by start year
Start year	Studies	As a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	0	0
2005	0	0
2006	1	0
2007	0	0
2008	1	1
2009	1	1
2010	5	3
2011	4	1
2012	5	1
2013	2	0
2014	2	1
2015	6	2
2016	11	3
2017	9	4
2018	6	4
2019	13	5
2020	18	8
2021	19	9
2022	16	5
2023	26	7
2024	23	14
2025	22	5
2026	23	8

Library tests named most

Largest condition groups

Mild cognitive impairment213 studies, 82 as a primary outcome
Dementia and Alzheimer's71 studies, 21 as a primary outcome
Aging, frailty and exercise25 studies, 9 as a primary outcome
Parkinson's disease12 studies, 1 as a primary outcome
Depression and bipolar disorder9 studies, 3 as a primary outcome
Healthy volunteers9 studies, 3 as a primary outcome
Obesity and diabetes7 studies, 5 as a primary outcome
Cardiovascular disease6 studies, 3 as a primary outcome
Cancer4 studies, 1 as a primary outcome
Sleep and sleep disorders4 studies, 2 as a primary outcome
Stroke3 studies, 0 as a primary outcome
Brain injury and concussion3 studies, 0 as a primary outcome

Phases

Participants

Lead sponsor: industry 17, other 196. Interventional 198, observational 15.

As a primary outcomeSecondary or other outcomeThe Trail Making Test

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
Study	Start	Phase	Conditions	Participants	Lead sponsor	Status	Library tests named, with the latest time point
NCT07883148	Start2024	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants52	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary8 months Verbal LearningSecondary8 months Verbal FluencySecondary8 months Digit Span TestSecondary8 months Complex Figure Copy and RecallSecondary8 months
NCT07865260	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease	Participants80	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary8 weeks Stroop Color-Word TestSecondary8 weeks Corsi Block-Tapping TestSecondary8 weeks
NCT07856043	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Cardiovascular disease	Participants18	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary12 weeks Symbol CodingSecondary12 weeks Selective Reminding TaskSecondary12 weeks
NCT07775079	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants96	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary8 weeks Task Switching TestPrimary8 weeks
NCT07764250	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants96	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary8 weeks
NCT07735910	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Depression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD	Participants60	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary2 weeks Stroop Color-Word TestPrimary2 weeks Digit Span TestPrimary2 weeks
NCT07733726	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Aging, frailty and exercise	Participants66	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary7 months Verbal FluencySecondary7 months
NCT07731334	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants384	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months Verbal LearningSecondary12 months Verbal FluencySecondary12 months Digit Span TestSecondary12 months Complex Figure Copy and RecallSecondary12 months Corsi Block-Tapping TestSecondary12 months Oddball Target DetectionSecondary
NCT07667478	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months
NCT07652775	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Depression and bipolar disorder	Participants45	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary5 weeks Stroop Color-Word TestSecondary5 weeks Verbal LearningSecondary5 weeks Digit Span TestSecondary5 weeks
NCT07646054	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants1,200	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months
NCT07642518	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Obesity and diabetes	Participants38	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary6 months Stroop Color-Word TestSecondary6 months Digit Span TestSecondary6 months Category FluencySecondary6 months Picture Naming TestSecondary6 months Short Story RecallSecondary6 months
NCT07636538	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease	Participants30	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary Stroop Color-Word TestSecondary Digit Span TestSecondary
NCT07629349	Start2020	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants600	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Block Copy TestPrimary6 months
NCT07616050	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease, Multiple sclerosis, Aging, frailty and exercise	Participants70	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary9 weeks Stroop Color-Word TestSecondary9 weeks
NCT07598409	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Healthy volunteers, Aging, frailty and exercise	Participants156	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary13 weeks Digit Span TestSecondary13 weeks
NCT07547111	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants42	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary8 weeks
NCT07517380	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Stroop Color-Word TestPrimary6 months Verbal LearningPrimary6 months Verbal FluencyPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Corsi Block-Tapping TestPrimary6 months
NCT07512193	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants10	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary4 weeks Verbal LearningPrimary4 weeks Verbal FluencySecondary4 weeks Digit Span TestSecondary4 weeks Picture Naming TestSecondary4 weeks Mnemonic Similarity TaskSecondary4 weeks
NCT07497334	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Aging, frailty and exercise	Participants45	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Stroop Color-Word TestSecondary6 months Digit Span TestSecondary6 months Symbol CodingSecondary6 months Task Switching TestSecondary6 months
NCT07423260	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants38	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary16 weeks Category FluencyPrimary16 weeks Arithmetic Fluency TaskPrimary16 weeks
NCT07402356	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Depression and bipolar disorder	Participants140	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Verbal LearningSecondary6 months Verbal FluencySecondary6 months N-Back TaskPrimarysame day Category FluencySecondary6 months Picture Naming TestSecondary6 months
NCT07385937	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants150	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary18 months Verbal FluencySecondary18 months Digit Span TestSecondary18 months Category FluencySecondary18 months Clock Drawing TaskSecondary18 months Cancellation TestSecondary18 months Delayed Recall ModuleSecondary18 months
NCT07376135	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants300	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestOther outcome18 months Stroop Color-Word TestOther outcome18 months Verbal LearningOther outcome18 months Digit Span TestOther outcome18 months Symbol CodingOther outcome18 months Short Story RecallOther outcome18 months Complex Figure Copy and RecallOther outcome18 months
NCT07366346	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants100	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary5 months Verbal LearningPrimary5 months Verbal FluencyPrimary5 months Category FluencyPrimary5 months

Questions, answered from the data

How many mild cognitive impairment trials use the Trail Making Test?

213 registered mild cognitive impairment studies on ClinicalTrials.gov name it in an outcome measure, 82 of them in a primary outcome: 25% of the condition's 859 studies with a cognitive outcome, against 14% of all of them. It is the test mild cognitive impairment trials name most.

Which tests do mild cognitive impairment trials use with the Trail Making Test?

The Digit Span Test (95 studies), Verbal Fluency (86 studies) and Verbal Learning (84 studies).

How many participants do phase 2 mild cognitive impairment trials that use the Trail Making Test enroll?

Half of the phase 2 studies that name it enroll 78 participants or fewer, and the middle half enroll 54 to 142. 19 of them give a size.

When do mild cognitive impairment trials measure the Trail Making Test?

Half of the primary outcomes that name the Trail Making Test are measured within 13 weeks of the start, and the middle half from 8 weeks to 7 months. 75 primary outcomes give a duration.

How many completed mild cognitive impairment trials that use the Trail Making Test have reported results?

46 of the 98 completed studies that name it, 47%, have reported results: 28 posted them on ClinicalTrials.gov, 34 have a results paper linked to the registry record, and 16 did both. The other 52 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.

How the studies are counted

For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.

The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.

A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.

A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.

The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.

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Clinical trials data

Trail Making Test in mild cognitive impairment trials: 213 registered studies

Registered mild cognitive impairment studies name it in an outcome measure: 213
Name it in a primary outcome, 38%: 82 of 213
Of the condition's 859 studies name it, against 14% of all registered studies: 25%; Other conditions
Median participants per study: 70; By phase

Try Trail Making Test A Try Trail Making Test B

Tests named in the same studies

The library tests that mild cognitive impairment studies naming the Trail Making Test name most often beside it.

1
Digit Span Test95 studies, 34 as a primary outcome
2
Verbal Fluency86 studies, 28 as a primary outcome
3
Verbal Learning84 studies, 44 as a primary outcome
4
Stroop Color-Word Test64 studies, 22 as a primary outcome
5
Category Fluency51 studies, 23 as a primary outcome
6
Symbol Coding42 studies, 22 as a primary outcome
7
Picture Naming Test41 studies, 11 as a primary outcome
8
Short Story Recall29 studies, 14 as a primary outcome
9
Complex Figure Copy and Recall22 studies, 9 as a primary outcome
10
Clock Drawing Task21 studies, 8 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Studies by start year

Each study counted once. 2026 is partly planned starts.

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table

Registered studies by start year
Start year	Studies	A test as a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	0	0
2005	0	0
2006	1	0
2007	0	0
2008	1	1
2009	1	1
2010	5	3
2011	4	1
2012	5	1
2013	2	0
2014	2	1
2015	6	2
2016	11	3
2017	9	4
2018	6	4
2019	13	5
2020	18	8
2021	19	9
2022	16	5
2023	26	7
2024	23	14
2025	22	5
2026	23	8

Phases and study sizes

By phase

Early phase 14 studies, 2 as a primary outcome
Phase 11 studies, 0 as a primary outcome
Phase 220 studies, 7 as a primary outcome
Phase 2/31 studies, 0 as a primary outcome
Phase 32 studies, 1 as a primary outcome
Phase 45 studies, 1 as a primary outcome
Not applicable165 studies, 67 as a primary outcome
Observational15 studies, 4 as a primary outcome

Participants per study

Phase 278 median, 54 to 142
Not applicable62 median, 38 to 128
Observational140 median, 80 to 425

Show as a table

Participants per mild cognitive impairment study that names the Trail Making Test, by phase
Phase	Studies with a size	Median	Middle half
Phase 2	19	78	54 to 142
Not applicable	165	62	38 to 128
Observational	15	140	80 to 425

When mild cognitive impairment trials measure it

Half of the primary outcomes that name the Trail Making Test are measured within 13 weeks of the start, and the middle half from 8 weeks to 7 months. 75 primary outcomes give a duration.

Latest time point of each outcome

Within a day11 outcomes, 5 as a primary outcome
Up to 4 weeks17 outcomes, 4 as a primary outcome
1 to 3 months57 outcomes, 31 as a primary outcome
3 to 6 months44 outcomes, 16 as a primary outcome
6 to 12 months43 outcomes, 9 as a primary outcome
1 to 2 years18 outcomes, 9 as a primary outcome
Over 2 years9 outcomes, 1 as a primary outcome
No duration given14 outcomes, 7 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

199 of the 213 outcome measures give a duration. A single visit counts as within a day.

Status, results, interventions and countries

Status

Recruiting48 studies, 18 as a primary outcome
Not yet recruiting15 studies, 3 as a primary outcome
Active, not recruiting6 studies, 4 as a primary outcome
Completed98 studies, 39 as a primary outcome
Stopped early5 studies, 2 as a primary outcome
Status unknown41 studies, 16 as a primary outcome

What they test

Behavioral78 studies, 34 as a primary outcome
Drug27 studies, 9 as a primary outcome
Device46 studies, 10 as a primary outcome
Dietary supplement15 studies, 4 as a primary outcome
Procedure6 studies, 1 as a primary outcome
Diagnostic test3 studies, 2 as a primary outcome
Biological2 studies, 0 as a primary outcome
Radiation1 studies, 0 as a primary outcome
Combination product4 studies, 2 as a primary outcome
Other63 studies, 30 as a primary outcome
None given9 studies, 3 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

35 countries in all. A study with sites in several counts in each; 11 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed mild cognitive impairment studies that name the Trail Making Test: 46 of 98, 47%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed mild cognitive impairment studies that name the Trail Making Test and every completed study, by how they reported results
Results	Completed mild cognitive impairment studies that name the Trail Making Test	Every completed study
Results on ClinicalTrials.gov and a paper	16, 16%	776, 10%
Results on ClinicalTrials.gov only	12, 12%	1,139, 14%
A results paper only	18, 18%	1,711, 22%
Neither	52, 53%	4,327, 54%

The 213 studies

Filter by phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.

213 studies match. 82 name the Trail Making Test in a primary outcome. Median size 70 participants. Median time to the primary outcome: 13 weeks.

Loading 213 studies; the filters turn on when they arrive.

By start year

2026 is partly planned starts.

Show as a table

Matching studies by start year
Start year	Studies	As a primary outcome
2000	0	0
2001	0	0
2002	0	0
2003	0	0
2004	0	0
2005	0	0
2006	1	0
2007	0	0
2008	1	1
2009	1	1
2010	5	3
2011	4	1
2012	5	1
2013	2	0
2014	2	1
2015	6	2
2016	11	3
2017	9	4
2018	6	4
2019	13	5
2020	18	8
2021	19	9
2022	16	5
2023	26	7
2024	23	14
2025	22	5
2026	23	8

Library tests named most

Largest condition groups

Mild cognitive impairment213 studies, 82 as a primary outcome
Dementia and Alzheimer's71 studies, 21 as a primary outcome
Aging, frailty and exercise25 studies, 9 as a primary outcome
Parkinson's disease12 studies, 1 as a primary outcome
Depression and bipolar disorder9 studies, 3 as a primary outcome
Healthy volunteers9 studies, 3 as a primary outcome
Obesity and diabetes7 studies, 5 as a primary outcome
Cardiovascular disease6 studies, 3 as a primary outcome
Cancer4 studies, 1 as a primary outcome
Sleep and sleep disorders4 studies, 2 as a primary outcome
Stroke3 studies, 0 as a primary outcome
Brain injury and concussion3 studies, 0 as a primary outcome

Phases

Participants

Lead sponsor: industry 17, other 196. Interventional 198, observational 15.

As a primary outcomeSecondary or other outcomeThe Trail Making Test

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
Study	Start	Phase	Conditions	Participants	Lead sponsor	Status	Library tests named, with the latest time point
NCT07883148	Start2024	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants52	Lead sponsorOther	StatusCompleted	Library tests named Trail Making TestSecondary8 months Verbal LearningSecondary8 months Verbal FluencySecondary8 months Digit Span TestSecondary8 months Complex Figure Copy and RecallSecondary8 months
NCT07865260	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease	Participants80	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary8 weeks Stroop Color-Word TestSecondary8 weeks Corsi Block-Tapping TestSecondary8 weeks
NCT07856043	Start2026	PhasePhase 1	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Cardiovascular disease	Participants18	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary12 weeks Symbol CodingSecondary12 weeks Selective Reminding TaskSecondary12 weeks
NCT07775079	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants96	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary8 weeks Task Switching TestPrimary8 weeks
NCT07764250	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants96	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary8 weeks
NCT07735910	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Depression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD	Participants60	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary2 weeks Stroop Color-Word TestPrimary2 weeks Digit Span TestPrimary2 weeks
NCT07733726	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Aging, frailty and exercise	Participants66	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary7 months Verbal FluencySecondary7 months
NCT07731334	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants384	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months Verbal LearningSecondary12 months Verbal FluencySecondary12 months Digit Span TestSecondary12 months Complex Figure Copy and RecallSecondary12 months Corsi Block-Tapping TestSecondary12 months Oddball Target DetectionSecondary
NCT07667478	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months
NCT07652775	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Depression and bipolar disorder	Participants45	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary5 weeks Stroop Color-Word TestSecondary5 weeks Verbal LearningSecondary5 weeks Digit Span TestSecondary5 weeks
NCT07646054	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants1,200	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary12 months Stroop Color-Word TestSecondary12 months
NCT07642518	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Obesity and diabetes	Participants38	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary6 months Stroop Color-Word TestSecondary6 months Digit Span TestSecondary6 months Category FluencySecondary6 months Picture Naming TestSecondary6 months Short Story RecallSecondary6 months
NCT07636538	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease	Participants30	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary Stroop Color-Word TestSecondary Digit Span TestSecondary
NCT07629349	Start2020	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants600	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Verbal LearningPrimary6 months Digit Span TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Block Copy TestPrimary6 months
NCT07616050	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment, Stroke, Parkinson's disease, Multiple sclerosis, Aging, frailty and exercise	Participants70	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary9 weeks Stroop Color-Word TestSecondary9 weeks
NCT07598409	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Healthy volunteers, Aging, frailty and exercise	Participants156	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary13 weeks Digit Span TestSecondary13 weeks
NCT07547111	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants42	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary8 weeks
NCT07517380	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants40	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary6 months Stroop Color-Word TestPrimary6 months Verbal LearningPrimary6 months Verbal FluencyPrimary6 months Digit Span TestPrimary6 months Picture Naming TestPrimary6 months Complex Figure Copy and RecallPrimary6 months Matrix ReasoningPrimary6 months Corsi Block-Tapping TestPrimary6 months
NCT07512193	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants10	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary4 weeks Verbal LearningPrimary4 weeks Verbal FluencySecondary4 weeks Digit Span TestSecondary4 weeks Picture Naming TestSecondary4 weeks Mnemonic Similarity TaskSecondary4 weeks
NCT07497334	Start2025	PhaseNot applicable	ConditionsMild cognitive impairment, Aging, frailty and exercise	Participants45	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Stroop Color-Word TestSecondary6 months Digit Span TestSecondary6 months Symbol CodingSecondary6 months Task Switching TestSecondary6 months
NCT07423260	Start2026	PhaseNot applicable	ConditionsMild cognitive impairment	Participants38	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestPrimary16 weeks Category FluencyPrimary16 weeks Arithmetic Fluency TaskPrimary16 weeks
NCT07402356	Start2025	PhaseObservational	ConditionsDementia and Alzheimer's, Mild cognitive impairment, Depression and bipolar disorder	Participants140	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestSecondary6 months Verbal LearningSecondary6 months Verbal FluencySecondary6 months N-Back TaskPrimarysame day Category FluencySecondary6 months Picture Naming TestSecondary6 months
NCT07385937	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants150	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestSecondary18 months Verbal FluencySecondary18 months Digit Span TestSecondary18 months Category FluencySecondary18 months Clock Drawing TaskSecondary18 months Cancellation TestSecondary18 months Delayed Recall ModuleSecondary18 months
NCT07376135	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants300	Lead sponsorOther	StatusNot yet recruiting	Library tests named Trail Making TestOther outcome18 months Stroop Color-Word TestOther outcome18 months Verbal LearningOther outcome18 months Digit Span TestOther outcome18 months Symbol CodingOther outcome18 months Short Story RecallOther outcome18 months Complex Figure Copy and RecallOther outcome18 months
NCT07366346	Start2026	PhaseNot applicable	ConditionsDementia and Alzheimer's, Mild cognitive impairment	Participants100	Lead sponsorOther	StatusRecruiting	Library tests named Trail Making TestPrimary5 months Verbal LearningPrimary5 months Verbal FluencyPrimary5 months Category FluencyPrimary5 months

Questions, answered from the data

How many mild cognitive impairment trials use the Trail Making Test?

Which tests do mild cognitive impairment trials use with the Trail Making Test?

The Digit Span Test (95 studies), Verbal Fluency (86 studies) and Verbal Learning (84 studies).

How many participants do phase 2 mild cognitive impairment trials that use the Trail Making Test enroll?

Half of the phase 2 studies that name it enroll 78 participants or fewer, and the middle half enroll 54 to 142. 19 of them give a size.

When do mild cognitive impairment trials measure the Trail Making Test?

Half of the primary outcomes that name the Trail Making Test are measured within 13 weeks of the start, and the middle half from 8 weeks to 7 months. 75 primary outcomes give a duration.

How many completed mild cognitive impairment trials that use the Trail Making Test have reported results?

How the studies are counted

The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.

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Trail Making Test in mild cognitive impairment trials: 213 registered studies

Tests named in the same studies

Studies by start year

Phases and study sizes

By phase

Participants per study

When mild cognitive impairment trials measure it

Latest time point of each outcome

Status, results, interventions and countries

Status

What they test

Where their sites are

Reported results

The 213 studies

Library tests named most

Largest condition groups

Phases

Participants

The studies, newest registration first

Questions, answered from the data

How many mild cognitive impairment trials use the Trail Making Test?

Which tests do mild cognitive impairment trials use with the Trail Making Test?

How many participants do phase 2 mild cognitive impairment trials that use the Trail Making Test enroll?

When do mild cognitive impairment trials measure the Trail Making Test?

How many completed mild cognitive impairment trials that use the Trail Making Test have reported results?

More on the Trail Making Test and mild cognitive impairment

The Trail Making Test in other conditions

Other tests in mild cognitive impairment trials

How the studies are counted

Run the Trail Making Test in your trial

Trail Making Test in mild cognitive impairment trials: 213 registered studies

Tests named in the same studies

Studies by start year

Phases and study sizes

By phase

Participants per study

When mild cognitive impairment trials measure it

Latest time point of each outcome

Status, results, interventions and countries

Status

What they test

Where their sites are

Reported results

The 213 studies

Library tests named most

Largest condition groups

Phases

Participants

The studies, newest registration first

Questions, answered from the data

How many mild cognitive impairment trials use the Trail Making Test?

Which tests do mild cognitive impairment trials use with the Trail Making Test?

How many participants do phase 2 mild cognitive impairment trials that use the Trail Making Test enroll?

When do mild cognitive impairment trials measure the Trail Making Test?

How many completed mild cognitive impairment trials that use the Trail Making Test have reported results?

More on the Trail Making Test and mild cognitive impairment

The Trail Making Test in other conditions

Other tests in mild cognitive impairment trials

How the studies are counted

Run the Trail Making Test in your trial