Clinical trials data
Trail Making Test in depression and bipolar disorder trials: 204 registered studies
Every registered depression and bipolar disorder study on ClinicalTrials.gov that names the Trail Making Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.
- Registered depression and bipolar disorder studies name it in an outcome measure
- 204
- Name it in a primary outcome, 25%
- 52 of 204
Tests named in the same studies
- 1
Verbal Learning69 studies, 21 as a primary outcome
- 2
Symbol Coding67 studies, 25 as a primary outcome
- 3
Digit Span Test67 studies, 19 as a primary outcome
- 4
Verbal Fluency57 studies, 18 as a primary outcome
- 5
Stroop Color-Word Test57 studies, 13 as a primary outcome
- 6
Card Sorting Test (Berg)21 studies, 7 as a primary outcome
- 7
Continuous Performance Test21 studies, 6 as a primary outcome
- 8
N-Back Task19 studies, 7 as a primary outcome
- 9
Category Fluency19 studies, 6 as a primary outcome
- 10
Choice Reaction Time19 studies, 5 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 2 | 1 |
| 2004 | 2 | 1 |
| 2005 | 1 | 1 |
| 2006 | 4 | 0 |
| 2007 | 2 | 0 |
| 2008 | 1 | 0 |
| 2009 | 1 | 0 |
| 2010 | 2 | 0 |
| 2011 | 7 | 0 |
| 2012 | 5 | 1 |
| 2013 | 3 | 1 |
| 2014 | 4 | 1 |
| 2015 | 10 | 7 |
| 2016 | 5 | 2 |
| 2017 | 15 | 6 |
| 2018 | 12 | 2 |
| 2019 | 10 | 1 |
| 2020 | 14 | 6 |
| 2021 | 14 | 2 |
| 2022 | 8 | 1 |
| 2023 | 27 | 6 |
| 2024 | 19 | 5 |
| 2025 | 22 | 5 |
| 2026 | 12 | 2 |
Phases and study sizes
By phase
- Early phase 13 studies, 0 as a primary outcome
- Phase 14 studies, 1 as a primary outcome
- Phase 1/23 studies, 0 as a primary outcome
- Phase 225 studies, 4 as a primary outcome
- Phase 2/33 studies, 1 as a primary outcome
- Phase 317 studies, 1 as a primary outcome
- Phase 415 studies, 3 as a primary outcome
- Not applicable109 studies, 27 as a primary outcome
- Observational25 studies, 15 as a primary outcome
Participants per study
- Phase 264 median, 30 to 100
- Phase 3152 median, 60 to 266
- Phase 456 median, 28 to 81
- Not applicable64 median, 43 to 120
- Observational121 median, 73 to 153
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Phase 2 | 24 | 64 | 30 to 100 |
| Phase 3 | 17 | 152 | 60 to 266 |
| Phase 4 | 15 | 56 | 28 to 81 |
| Not applicable | 107 | 64 | 43 to 120 |
| Observational | 25 | 121 | 73 to 153 |
When depression and bipolar disorder trials measure it
Latest time point of each outcome
- Within a day9 outcomes, 2 as a primary outcome
- Up to 4 weeks52 outcomes, 12 as a primary outcome
- 1 to 3 months77 outcomes, 20 as a primary outcome
- 3 to 6 months27 outcomes, 7 as a primary outcome
- 6 to 12 months13 outcomes, 1 as a primary outcome
- 1 to 2 years5 outcomes, 3 as a primary outcome
- Over 2 years3 outcomes, 0 as a primary outcome
- No duration given18 outcomes, 7 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
186 of the 204 outcome measures give a duration. A single visit counts as within a day.
Status, results, interventions and countries
Status
- Recruiting45 studies, 8 as a primary outcome
- Not yet recruiting6 studies, 1 as a primary outcome
- Active, not recruiting6 studies, 2 as a primary outcome
- Completed95 studies, 31 as a primary outcome
- Stopped early16 studies, 4 as a primary outcome
- Status unknown36 studies, 6 as a primary outcome
What they test
- Behavioral47 studies, 10 as a primary outcome
- Drug65 studies, 8 as a primary outcome
- Device55 studies, 11 as a primary outcome
- Dietary supplement10 studies, 4 as a primary outcome
- Procedure6 studies, 1 as a primary outcome
- Diagnostic test2 studies, 1 as a primary outcome
- Biological3 studies, 1 as a primary outcome
- Radiation1 studies, 1 as a primary outcome
- Combination product2 studies, 0 as a primary outcome
- Genetic1 studies, 1 as a primary outcome
- Other35 studies, 14 as a primary outcome
- None given14 studies, 8 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States56 studies, 16 as a primary outcome
- Canada24 studies, 6 as a primary outcome
- China23 studies, 4 as a primary outcome
- Denmark18 studies, 6 as a primary outcome
- Germany14 studies, 1 as a primary outcome
- France13 studies, 1 as a primary outcome
- Spain9 studies, 1 as a primary outcome
- Italy5 studies, 2 as a primary outcome
- Netherlands5 studies, 1 as a primary outcome
- Switzerland5 studies, 1 as a primary outcome
- Taiwan5 studies, 1 as a primary outcome
- Austria4 studies, 1 as a primary outcome
42 countries in all. A study with sites in several counts in each; 7 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed depression and bipolar disorder studies that name the Trail Making Test: 55 of 95, 58%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed depression and bipolar disorder studies that name the Trail Making Test | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 12, 13% | 776, 10% |
| Results on ClinicalTrials.gov only | 12, 13% | 1,139, 14% |
| A results paper only | 31, 33% | 1,711, 22% |
| Neither | 40, 42% | 4,327, 54% |
The 204 studies
204 studies match. 52 name the Trail Making Test in a primary outcome. Median size 73 participants. Median time to the primary outcome: 9 weeks.
Loading 204 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 1 that started before 2000 and 1 planned to start after 2026.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 2 | 1 |
| 2004 | 2 | 1 |
| 2005 | 1 | 1 |
| 2006 | 4 | 0 |
| 2007 | 2 | 0 |
| 2008 | 1 | 0 |
| 2009 | 1 | 0 |
| 2010 | 2 | 0 |
| 2011 | 7 | 0 |
| 2012 | 5 | 1 |
| 2013 | 3 | 1 |
| 2014 | 4 | 1 |
| 2015 | 10 | 7 |
| 2016 | 5 | 2 |
| 2017 | 15 | 6 |
| 2018 | 12 | 2 |
| 2019 | 10 | 1 |
| 2020 | 14 | 6 |
| 2021 | 14 | 2 |
| 2022 | 8 | 1 |
| 2023 | 27 | 6 |
| 2024 | 19 | 5 |
| 2025 | 22 | 5 |
| 2026 | 12 | 2 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: industry 15, NIH 1, other 188. Interventional 179, observational 25.
As a primary outcomeSecondary or other outcomeThe Trail Making Test
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07845409 | Start2027 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants138 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07780695 | Start2023 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants45 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07765355 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Anxiety, PTSD and OCD | Participants60 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07757997 | Start2026 | PhaseObservational | ConditionsDepression and bipolar disorder | Participants143 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07755839 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Cancer, Anxiety, PTSD and OCD | Participants60 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07735910 | Start2026 | PhaseNot applicable | ConditionsMild cognitive impairment, Depression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD | Participants60 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07710222 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants60 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07665840 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD | Participants67 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07664852 | Start2026 | PhasePhase 3 | ConditionsDepression and bipolar disorder | Participants126 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07652775 | Start2026 | PhaseNot applicable | ConditionsMild cognitive impairment, Depression and bipolar disorder | Participants45 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07633626 | Start2026 | PhaseObservational | ConditionsDepression and bipolar disorder, Cancer | Participants24 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07619092 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants145 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07608796 | Start2026 | PhasePhase 2 | ConditionsDepression and bipolar disorder | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07523048 | Start2025 | PhasePhase 2 | ConditionsDepression and bipolar disorder | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07508215 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07462013 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07402356 | Start2025 | PhaseObservational | ConditionsDementia and Alzheimer's, Mild cognitive impairment, Depression and bipolar disorder | Participants140 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07350226 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants86 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT07324070 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants50 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07309302 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Anxiety, PTSD and OCD | Participants64 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07258914 | Start2024 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Autism | Participants25 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07143838 | Start2026 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants12 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07039903 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, ADHD | Participants68 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07022171 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder | Participants86 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07009223 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Aging, frailty and exercise | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
Questions, answered from the data
How many depression and bipolar disorder trials use the Trail Making Test?
204 registered depression and bipolar disorder studies on ClinicalTrials.gov name it in an outcome measure, 52 of them in a primary outcome: 16% of the condition's 1,247 studies with a cognitive outcome, against 14% of all of them. It is the test depression and bipolar disorder trials name most.
Which tests do depression and bipolar disorder trials use with the Trail Making Test?
Verbal Learning (69 studies), Symbol Coding (67 studies) and the Digit Span Test (67 studies).
How many participants do phase 2 depression and bipolar disorder trials that use the Trail Making Test enroll?
Half of the phase 2 studies that name it enroll 64 participants or fewer, and the middle half enroll 30 to 100. 24 of them give a size.
When do depression and bipolar disorder trials measure the Trail Making Test?
Half of the primary outcomes that name the Trail Making Test are measured within 9 weeks of the start, and the middle half from 4 weeks to 13 weeks. 45 primary outcomes give a duration.
How many completed depression and bipolar disorder trials that use the Trail Making Test have reported results?
55 of the 95 completed studies that name it, 58%, have reported results: 24 posted them on ClinicalTrials.gov, 43 have a results paper linked to the registry record, and 12 did both. The other 40 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.
Run the Trail Making Test in your trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.