Clinical trials data
Trail Making Test in schizophrenia and psychosis trials: 102 registered studies
Every registered schizophrenia and psychosis study on ClinicalTrials.gov that names the Trail Making Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.
- Registered schizophrenia and psychosis studies name it in an outcome measure
- 102
- Name it in a primary outcome, 18%
- 18 of 102
Tests named in the same studies
- 1
Verbal Learning43 studies, 9 as a primary outcome
- 2
Verbal Fluency30 studies, 4 as a primary outcome
- 3
Digit Span Test27 studies, 6 as a primary outcome
- 4
Continuous Performance Test21 studies, 8 as a primary outcome
- 5
Category Fluency21 studies, 5 as a primary outcome
- 6
Card Sorting Test (Berg)19 studies, 2 as a primary outcome
- 7
Symbol Coding18 studies, 2 as a primary outcome
- 8
Stroop Color-Word Test14 studies, 0 as a primary outcome
- 9
Letter-Number Sequencing Task12 studies, 2 as a primary outcome
- 10
Tower Planning12 studies, 0 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 1 | 1 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 1 | 0 |
| 2004 | 2 | 0 |
| 2005 | 3 | 0 |
| 2006 | 1 | 1 |
| 2007 | 3 | 1 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 4 | 2 |
| 2011 | 3 | 0 |
| 2012 | 4 | 1 |
| 2013 | 4 | 1 |
| 2014 | 7 | 1 |
| 2015 | 4 | 0 |
| 2016 | 9 | 0 |
| 2017 | 3 | 1 |
| 2018 | 5 | 0 |
| 2019 | 9 | 3 |
| 2020 | 5 | 1 |
| 2021 | 4 | 2 |
| 2022 | 8 | 1 |
| 2023 | 4 | 0 |
| 2024 | 9 | 1 |
| 2025 | 4 | 0 |
| 2026 | 5 | 1 |
Phases and study sizes
By phase
- Phase 1/21 studies, 0 as a primary outcome
- Phase 212 studies, 2 as a primary outcome
- Phase 2/32 studies, 0 as a primary outcome
- Phase 36 studies, 1 as a primary outcome
- Phase 411 studies, 3 as a primary outcome
- Not applicable67 studies, 11 as a primary outcome
- Observational3 studies, 1 as a primary outcome
Participants per study
- Phase 259 median, 40 to 74
- Phase 475 median, 43 to 135
- Not applicable60 median, 40 to 110
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Phase 2 | 12 | 59 | 40 to 74 |
| Phase 4 | 11 | 75 | 43 to 135 |
| Not applicable | 66 | 60 | 40 to 110 |
When schizophrenia and psychosis trials measure it
Latest time point of each outcome
- Within a day10 outcomes, 1 as a primary outcome
- Up to 4 weeks20 outcomes, 6 as a primary outcome
- 1 to 3 months25 outcomes, 5 as a primary outcome
- 3 to 6 months25 outcomes, 4 as a primary outcome
- 6 to 12 months11 outcomes, 0 as a primary outcome
- 1 to 2 years5 outcomes, 0 as a primary outcome
- Over 2 years2 outcomes, 1 as a primary outcome
- No duration given4 outcomes, 1 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
98 of the 102 outcome measures give a duration. A single visit counts as within a day.
Status, results, interventions and countries
Status
- Recruiting16 studies, 1 as a primary outcome
- Not yet recruiting1 studies, 1 as a primary outcome
- Active, not recruiting2 studies, 0 as a primary outcome
- Completed60 studies, 12 as a primary outcome
- Stopped early5 studies, 0 as a primary outcome
- Status unknown18 studies, 4 as a primary outcome
What they test
- Behavioral38 studies, 8 as a primary outcome
- Drug30 studies, 6 as a primary outcome
- Device22 studies, 3 as a primary outcome
- Dietary supplement5 studies, 0 as a primary outcome
- Diagnostic test1 studies, 0 as a primary outcome
- Biological1 studies, 0 as a primary outcome
- Other24 studies, 6 as a primary outcome
- None given2 studies, 1 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States25 studies, 6 as a primary outcome
- Canada10 studies, 1 as a primary outcome
- France9 studies, 1 as a primary outcome
- Spain9 studies, 2 as a primary outcome
- Taiwan8 studies, 2 as a primary outcome
- Germany6 studies, 0 as a primary outcome
- China4 studies, 2 as a primary outcome
- Denmark4 studies, 0 as a primary outcome
- India4 studies, 1 as a primary outcome
- Italy4 studies, 1 as a primary outcome
- Hong Kong3 studies, 1 as a primary outcome
- Israel3 studies, 0 as a primary outcome
26 countries in all. A study with sites in several counts in each; 8 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed schizophrenia and psychosis studies that name the Trail Making Test: 35 of 60, 58%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed schizophrenia and psychosis studies that name the Trail Making Test | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 5, 8% | 776, 10% |
| Results on ClinicalTrials.gov only | 13, 22% | 1,139, 14% |
| A results paper only | 17, 28% | 1,711, 22% |
| Neither | 25, 42% | 4,327, 54% |
The 102 studies
102 studies match. 18 name the Trail Making Test in a primary outcome. Median size 60 participants. Median time to the primary outcome: 8 weeks.
Loading 102 studies; the filters turn on when they arrive.
2026 is partly planned starts.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 1 | 1 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 1 | 0 |
| 2004 | 2 | 0 |
| 2005 | 3 | 0 |
| 2006 | 1 | 1 |
| 2007 | 3 | 1 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 4 | 2 |
| 2011 | 3 | 0 |
| 2012 | 4 | 1 |
| 2013 | 4 | 1 |
| 2014 | 7 | 1 |
| 2015 | 4 | 0 |
| 2016 | 9 | 0 |
| 2017 | 3 | 1 |
| 2018 | 5 | 0 |
| 2019 | 9 | 3 |
| 2020 | 5 | 1 |
| 2021 | 4 | 2 |
| 2022 | 8 | 1 |
| 2023 | 4 | 0 |
| 2024 | 9 | 1 |
| 2025 | 4 | 0 |
| 2026 | 5 | 1 |
Library tests named most
Conditions
Phases
Participants
Lead sponsor: industry 8, other 94. Interventional 99, observational 3.
As a primary outcomeSecondary or other outcomeThe Trail Making Test
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07747181 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants135 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07702526 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants160 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07680959 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants100 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07633899 | Start2022 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants32 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07427485 | Start2025 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants40 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07196423 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants106 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07184619 | Start2026 | PhasePhase 3 | ConditionsSchizophrenia and psychosis | Participants400 | Lead sponsorIndustry | StatusRecruiting | Library tests named
|
| NCT07091344 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07056894 | Start2026 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Substance use and addiction | Participants50 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07001878 | Start2025 | PhasePhase 4 | ConditionsSchizophrenia and psychosis, Substance use and addiction | Participants24 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06743711 | Start2025 | PhaseObservational | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder, Cardiovascular disease | Participants75 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06643871 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants40 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06624462 | Start2023 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder, Obesity and diabetes | Participants84 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06603922 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants252 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06542640 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Healthy volunteers | Participants300 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06474195 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants104 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT06426134 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder | Participants28 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06423651 | Start2022 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants160 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06038955 | Start2022 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder | Participants62 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06005103 | Start2024 | PhaseNot applicable | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder | Participants117 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05973110 | Start2023 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants52 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05958875 | Start2024 | PhasePhase 4 | ConditionsSchizophrenia and psychosis | Participants418 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05731414 | Start2023 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants360 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT05603104 | Start2025 | PhasePhase 3 | ConditionsSchizophrenia and psychosis, Depression and bipolar disorder | Participants1 | Lead sponsorOther | StatusStopped early | Library tests named
|
| NCT05582980 | Start2020 | PhaseNot applicable | ConditionsSchizophrenia and psychosis | Participants60 | Lead sponsorOther | StatusCompleted | Library tests named
|
Questions, answered from the data
How many schizophrenia and psychosis trials use the Trail Making Test?
102 registered schizophrenia and psychosis studies on ClinicalTrials.gov name it in an outcome measure, 18 of them in a primary outcome: 16% of the condition's 640 studies with a cognitive outcome, against 14% of all of them. It is the 3rd most named test in schizophrenia and psychosis trials.
Which tests do schizophrenia and psychosis trials use with the Trail Making Test?
Verbal Learning (43 studies), Verbal Fluency (30 studies) and the Digit Span Test (27 studies).
How many participants do phase 2 schizophrenia and psychosis trials that use the Trail Making Test enroll?
Half of the phase 2 studies that name it enroll 59 participants or fewer, and the middle half enroll 40 to 74. 12 of them give a size.
When do schizophrenia and psychosis trials measure the Trail Making Test?
Half of the primary outcomes that name the Trail Making Test are measured within 8 weeks of the start, and the middle half from 4 weeks to 16 weeks. 17 primary outcomes give a duration.
How many completed schizophrenia and psychosis trials that use the Trail Making Test have reported results?
35 of the 60 completed studies that name it, 58%, have reported results: 18 posted them on ClinicalTrials.gov, 22 have a results paper linked to the registry record, and 5 did both. The other 25 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
The census counts Trail Making Test A and Trail Making Test B as one test family, so this page counts their studies together.
Run the Trail Making Test in your trial
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