Clinical trials data
Digit Span Test in healthy volunteer trials: 64 registered studies
Every registered healthy volunteers study on ClinicalTrials.gov that names the Digit Span Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.
- Registered healthy volunteers studies name it in an outcome measure
- 64
- Name it in a primary outcome, 48%
- 31 of 64
Tests named in the same studies
- 1
Stroop Color-Word Test20 studies, 11 as a primary outcome
- 2
Trail Making Test19 studies, 11 as a primary outcome
- 3
Verbal Fluency11 studies, 1 as a primary outcome
- 4
Card Sorting Test (Berg)10 studies, 7 as a primary outcome
- 5
Verbal Learning10 studies, 6 as a primary outcome
- 6
Matrix Reasoning8 studies, 4 as a primary outcome
- 7
Task Switching Test6 studies, 6 as a primary outcome
- 8
Symbol Coding6 studies, 4 as a primary outcome
- 9
Go/No-Go Task5 studies, 2 as a primary outcome
- 10
N-Back Task5 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 1 | 1 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 2 | 2 |
| 2011 | 1 | 0 |
| 2012 | 2 | 2 |
| 2013 | 3 | 2 |
| 2014 | 2 | 2 |
| 2015 | 5 | 1 |
| 2016 | 5 | 1 |
| 2017 | 4 | 2 |
| 2018 | 1 | 0 |
| 2019 | 6 | 3 |
| 2020 | 1 | 0 |
| 2021 | 1 | 1 |
| 2022 | 4 | 2 |
| 2023 | 6 | 2 |
| 2024 | 3 | 1 |
| 2025 | 8 | 4 |
| 2026 | 7 | 4 |
Phases and study sizes
By phase
- Phase 12 studies, 1 as a primary outcome
- Phase 1/21 studies, 0 as a primary outcome
- Phase 23 studies, 1 as a primary outcome
- Phase 41 studies, 1 as a primary outcome
- Not applicable49 studies, 22 as a primary outcome
- Observational8 studies, 6 as a primary outcome
Participants per study
- Not applicable90 median, 44 to 200
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Not applicable | 49 | 90 | 44 to 200 |
When healthy volunteer trials measure it
Latest time point of each outcome
- Within a day15 outcomes, 5 as a primary outcome
- Up to 4 weeks13 outcomes, 8 as a primary outcome
- 1 to 3 months18 outcomes, 7 as a primary outcome
- 3 to 6 months8 outcomes, 5 as a primary outcome
- 6 to 12 months2 outcomes, 1 as a primary outcome
- 1 to 2 years2 outcomes, 1 as a primary outcome
- Over 2 years1 outcomes, 1 as a primary outcome
- No duration given5 outcomes, 3 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
59 of the 64 outcome measures give a duration. A single visit counts as within a day.
Status, results, interventions and countries
Status
- Recruiting8 studies, 5 as a primary outcome
- Not yet recruiting3 studies, 2 as a primary outcome
- Active, not recruiting1 studies, 0 as a primary outcome
- Completed41 studies, 18 as a primary outcome
- Stopped early2 studies, 1 as a primary outcome
- Status unknown9 studies, 5 as a primary outcome
What they test
- Behavioral22 studies, 11 as a primary outcome
- Drug9 studies, 3 as a primary outcome
- Device8 studies, 3 as a primary outcome
- Dietary supplement9 studies, 5 as a primary outcome
- Procedure1 studies, 0 as a primary outcome
- Diagnostic test2 studies, 1 as a primary outcome
- Other19 studies, 8 as a primary outcome
- None given3 studies, 2 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States10 studies, 8 as a primary outcome
- Taiwan7 studies, 4 as a primary outcome
- Germany6 studies, 1 as a primary outcome
- Spain4 studies, 1 as a primary outcome
- Singapore3 studies, 3 as a primary outcome
- Switzerland3 studies, 0 as a primary outcome
- Türkiye3 studies, 1 as a primary outcome
- United Kingdom3 studies, 1 as a primary outcome
- China2 studies, 0 as a primary outcome
- France2 studies, 0 as a primary outcome
- Hong Kong2 studies, 1 as a primary outcome
- Israel2 studies, 1 as a primary outcome
21 countries in all. A study with sites in several counts in each; 8 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed healthy volunteers studies that name the Digit Span Test: 16 of 41, 39%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed healthy volunteers studies that name the Digit Span Test | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 0, 0% | 776, 10% |
| Results on ClinicalTrials.gov only | 5, 12% | 1,139, 14% |
| A results paper only | 11, 27% | 1,711, 22% |
| Neither | 25, 61% | 4,327, 54% |
The 64 studies
64 studies match. 31 name the Digit Span Test in a primary outcome. Median size 90 participants. Median time to the primary outcome: 6 weeks.
Loading 64 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 1 that started before 2000 and 1 planned to start after 2026.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 1 | 1 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 0 | 0 |
| 2009 | 0 | 0 |
| 2010 | 2 | 2 |
| 2011 | 1 | 0 |
| 2012 | 2 | 2 |
| 2013 | 3 | 2 |
| 2014 | 2 | 2 |
| 2015 | 5 | 1 |
| 2016 | 5 | 1 |
| 2017 | 4 | 2 |
| 2018 | 1 | 0 |
| 2019 | 6 | 3 |
| 2020 | 1 | 0 |
| 2021 | 1 | 1 |
| 2022 | 4 | 2 |
| 2023 | 6 | 2 |
| 2024 | 3 | 1 |
| 2025 | 8 | 4 |
| 2026 | 7 | 4 |
Library tests named most
Conditions
Phases
Participants
Lead sponsor: industry 7, other 57. Interventional 56, observational 8.
As a primary outcomeSecondary or other outcomeThe Digit Span Test
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07841457 | Start2027 | PhaseNot applicable | ConditionsHealthy volunteers | Participants20 | Lead sponsorIndustry | StatusNot yet recruiting | Library tests named
|
| NCT07809412 | Start2025 | PhaseNot applicable | ConditionsHealthy volunteers | Participants20 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07650006 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants30 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07637487 | Start2023 | PhaseNot applicable | ConditionsHealthy volunteers | Participants220 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07623811 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants313 | Lead sponsorIndustry | StatusCompleted | Library tests named
|
| NCT07598409 | Start2025 | PhaseNot applicable | ConditionsMild cognitive impairment, Healthy volunteers, Aging, frailty and exercise | Participants156 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07572240 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants72 | Lead sponsorIndustry | StatusActive, not recruiting | Library tests named
|
| NCT07569120 | Start2026 | PhaseNot applicable | ConditionsParkinson's disease, Healthy volunteers, Aging, frailty and exercise | Participants165 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07556250 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants225 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07494149 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants158 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07443904 | Start2026 | PhaseNot applicable | ConditionsHealthy volunteers | Participants297 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07443189 | Start2021 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants233 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07379164 | Start2025 | PhaseNot applicable | ConditionsHealthy volunteers, Pain and fatigue | Participants80 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07258433 | Start2025 | PhaseNot applicable | ConditionsHealthy volunteers, Sleep and sleep disorders | Participants120 | Lead sponsorIndustry | StatusCompleted | Library tests named
|
| NCT07208279 | Start2025 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants16 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07144930 | Start2025 | PhaseNot applicable | ConditionsStroke, Healthy volunteers | Participants210 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07132281 | Start2025 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants120 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07039708 | Start2025 | PhaseNot applicable | ConditionsMild cognitive impairment, Healthy volunteers, Aging, frailty and exercise | Participants60 | Lead sponsorOther | StatusStopped early | Library tests named
|
| NCT06816667 | Start2024 | PhasePhase 1/2 | ConditionsDepression and bipolar disorder, Healthy volunteers, Anxiety, PTSD and OCD | Participants40 | Lead sponsorIndustry | StatusCompleted | Library tests named
|
| NCT06616285 | Start2024 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants80 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06588920 | Start2024 | PhaseObservational | ConditionsParkinson's disease, Healthy volunteers, Aging, frailty and exercise | Participants70 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06425679 | Start2023 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants120 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06412887 | Start2023 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants24 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06240286 | Start2015 | PhaseNot applicable | ConditionsHealthy volunteers | Participants44 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06090942 | Start2023 | PhaseNot applicable | ConditionsHealthy volunteers, Aging, frailty and exercise | Participants90 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
Questions, answered from the data
How many healthy volunteer trials use the Digit Span Test?
64 registered healthy volunteers studies on ClinicalTrials.gov name it in an outcome measure, 31 of them in a primary outcome: 10% of the condition's 656 studies with a cognitive outcome, against 10% of all of them. It is the 3rd most named test in healthy volunteer trials.
Which tests do healthy volunteer trials use with the Digit Span Test?
The Stroop Color-Word Test (20 studies), the Trail Making Test (19 studies) and Verbal Fluency (11 studies).
When do healthy volunteer trials measure the Digit Span Test?
Half of the primary outcomes that name the Digit Span Test are measured within 6 weeks of the start, and the middle half from 1 week to 4 months. 28 primary outcomes give a duration.
How many completed healthy volunteer trials that use the Digit Span Test have reported results?
16 of the 41 completed studies that name it, 39%, have reported results: 5 posted them on ClinicalTrials.gov, 11 have a results paper linked to the registry record, and 0 did both. The other 25 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Run the Digit Span Test in your trial
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