Clinical trials data
Digit Span Test in cardiovascular trials: 59 registered studies
Every registered cardiovascular disease study on ClinicalTrials.gov that names the Digit Span Test in an outcome measure: how often it is a primary outcome, the tests named with it, how large the studies are and when they measure it.
- Registered cardiovascular disease studies name it in an outcome measure
- 59
- Name it in a primary outcome, 34%
- 20 of 59
Tests named in the same studies
- 1
Trail Making Test32 studies, 12 as a primary outcome
- 2
Verbal Learning29 studies, 11 as a primary outcome
- 3
Verbal Fluency22 studies, 5 as a primary outcome
- 4
Stroop Color-Word Test18 studies, 6 as a primary outcome
- 5
Symbol Coding11 studies, 4 as a primary outcome
- 6
Category Fluency7 studies, 5 as a primary outcome
- 7
Picture Naming Test6 studies, 2 as a primary outcome
- 8
N-Back Task5 studies, 4 as a primary outcome
- 9
Pattern and Letter Comparison4 studies, 3 as a primary outcome
- 10
Stop-Signal Task3 studies, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
Studies by start year
A test as a primary outcomeOnly in secondary or other outcomes
Show as a table
| Start year | Studies | A test as a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 0 | 0 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 2 | 1 |
| 2009 | 1 | 1 |
| 2010 | 1 | 1 |
| 2011 | 0 | 0 |
| 2012 | 1 | 0 |
| 2013 | 3 | 2 |
| 2014 | 4 | 0 |
| 2015 | 3 | 0 |
| 2016 | 3 | 2 |
| 2017 | 1 | 0 |
| 2018 | 3 | 1 |
| 2019 | 3 | 0 |
| 2020 | 4 | 4 |
| 2021 | 5 | 1 |
| 2022 | 4 | 0 |
| 2023 | 5 | 0 |
| 2024 | 6 | 1 |
| 2025 | 5 | 4 |
| 2026 | 4 | 1 |
Phases and study sizes
By phase
- Early phase 11 studies, 0 as a primary outcome
- Phase 11 studies, 0 as a primary outcome
- Phase 26 studies, 1 as a primary outcome
- Phase 41 studies, 0 as a primary outcome
- Not applicable40 studies, 16 as a primary outcome
- Observational10 studies, 3 as a primary outcome
Participants per study
- Not applicable58 median, 32 to 143
- Observational63 median, 33 to 100
Show as a table
| Phase | Studies with a size | Median | Middle half |
|---|---|---|---|
| Not applicable | 40 | 58 | 32 to 143 |
| Observational | 10 | 63 | 33 to 100 |
When cardiovascular trials measure it
Latest time point of each outcome
- Within a day8 outcomes, 3 as a primary outcome
- Up to 4 weeks4 outcomes, 3 as a primary outcome
- 1 to 3 months8 outcomes, 3 as a primary outcome
- 3 to 6 months22 outcomes, 5 as a primary outcome
- 6 to 12 months11 outcomes, 2 as a primary outcome
- 1 to 2 years2 outcomes, 2 as a primary outcome
- Over 2 years2 outcomes, 0 as a primary outcome
- No duration given2 outcomes, 2 as a primary outcome
A test as a primary outcomeOnly in secondary or other outcomes
57 of the 59 outcome measures give a duration. A single visit counts as within a day.
Status, results, interventions and countries
Status
- Recruiting8 studies, 2 as a primary outcome
- Not yet recruiting2 studies, 2 as a primary outcome
- Active, not recruiting3 studies, 0 as a primary outcome
- Completed28 studies, 11 as a primary outcome
- Stopped early5 studies, 2 as a primary outcome
- Status unknown13 studies, 3 as a primary outcome
What they test
- Behavioral14 studies, 4 as a primary outcome
- Drug9 studies, 1 as a primary outcome
- Device8 studies, 1 as a primary outcome
- Dietary supplement8 studies, 3 as a primary outcome
- Procedure7 studies, 2 as a primary outcome
- Diagnostic test7 studies, 1 as a primary outcome
- Biological1 studies, 0 as a primary outcome
- Other16 studies, 7 as a primary outcome
- None given3 studies, 2 as a primary outcome
Intervention types as registered. A study can list several; observational studies often list none.
Where their sites are
- United States23 studies, 8 as a primary outcome
- Canada9 studies, 4 as a primary outcome
- China5 studies, 0 as a primary outcome
- United Kingdom4 studies, 3 as a primary outcome
- Brazil2 studies, 1 as a primary outcome
- Netherlands2 studies, 0 as a primary outcome
- Spain2 studies, 0 as a primary outcome
- Taiwan2 studies, 0 as a primary outcome
- Belgium1 studies, 1 as a primary outcome
- Denmark1 studies, 1 as a primary outcome
- Finland1 studies, 1 as a primary outcome
- France1 studies, 0 as a primary outcome
18 countries in all. A study with sites in several counts in each; 2 list no site.
Reported results
Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.
Completed cardiovascular disease studies that name the Digit Span Test: 15 of 28, 54%
Every completed study with a cognitive outcome: 3,626 of 7,953, 46%
| Results | Completed cardiovascular disease studies that name the Digit Span Test | Every completed study |
|---|---|---|
| Results on ClinicalTrials.gov and a paper | 8, 29% | 776, 10% |
| Results on ClinicalTrials.gov only | 4, 14% | 1,139, 14% |
| A results paper only | 3, 11% | 1,711, 22% |
| Neither | 13, 46% | 4,327, 54% |
The 59 studies
59 studies match. 20 name the Digit Span Test in a primary outcome. Median size 62 participants. Median time to the primary outcome: 15 weeks.
Loading 59 studies; the filters turn on when they arrive.
2026 is partly planned starts. Not shown: 1 planned to start after 2026.
Show as a table
| Start year | Studies | As a primary outcome |
|---|---|---|
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 0 |
| 2003 | 0 | 0 |
| 2004 | 0 | 0 |
| 2005 | 0 | 0 |
| 2006 | 0 | 0 |
| 2007 | 0 | 0 |
| 2008 | 2 | 1 |
| 2009 | 1 | 1 |
| 2010 | 1 | 1 |
| 2011 | 0 | 0 |
| 2012 | 1 | 0 |
| 2013 | 3 | 2 |
| 2014 | 4 | 0 |
| 2015 | 3 | 0 |
| 2016 | 3 | 2 |
| 2017 | 1 | 0 |
| 2018 | 3 | 1 |
| 2019 | 3 | 0 |
| 2020 | 4 | 4 |
| 2021 | 5 | 1 |
| 2022 | 4 | 0 |
| 2023 | 5 | 0 |
| 2024 | 6 | 1 |
| 2025 | 5 | 4 |
| 2026 | 4 | 1 |
Library tests named most
Largest condition groups
Phases
Participants
Lead sponsor: other 59. Interventional 49, observational 10.
As a primary outcomeSecondary or other outcomeThe Digit Span Test
The studies, newest registration first
Each number opens the study's record on ClinicalTrials.gov.
| Study | Start | Phase | Conditions | Participants | Lead sponsor | Status | Library tests named, with the latest time point |
|---|---|---|---|---|---|---|---|
| NCT07862452 | Start2027 | PhaseNot applicable | ConditionsObesity and diabetes, Cardiovascular disease | Participants400 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT07740967 | Start2026 | PhaseNot applicable | ConditionsSleep and sleep disorders, Pain and fatigue, Cardiovascular disease | Participants34 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07729930 | Start2026 | PhaseNot applicable | ConditionsSleep and sleep disorders, Pain and fatigue, Cardiovascular disease | Participants38 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07692958 | Start2026 | PhaseNot applicable | ConditionsCardiovascular disease | Participants160 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07689500 | Start2025 | PhaseNot applicable | ConditionsDelirium, surgery and intensive care, Cardiovascular disease | Participants153 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT07607795 | Start2026 | PhaseNot applicable | ConditionsCardiovascular disease | Participants30 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07319117 | Start2025 | PhaseNot applicable | ConditionsDepression and bipolar disorder, Sleep and sleep disorders, Anxiety, PTSD and OCD, Pain and fatigue, Cardiovascular disease | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT07200661 | Start2024 | PhaseNot applicable | ConditionsStroke, Cardiovascular disease | Participants30 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06867198 | Start2025 | PhaseNot applicable | ConditionsObesity and diabetes, Cardiovascular disease | Participants72 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06857994 | Start2025 | PhaseObservational | ConditionsObesity and diabetes, Cardiovascular disease | Participants101 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT06855953 | Start2025 | PhaseNot applicable | ConditionsCardiovascular disease | Participants40 | Lead sponsorOther | StatusNot yet recruiting | Library tests named
|
| NCT06735599 | Start2024 | PhaseNot applicable | ConditionsObesity and diabetes, Cardiovascular disease | Participants40 | Lead sponsorOther | StatusRecruiting | Library tests named
|
| NCT06463496 | Start2024 | PhaseObservational | ConditionsCardiovascular disease | Participants60 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT06369402 | Start2024 | PhaseObservational | ConditionsCardiovascular disease | Participants40 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT06027788 | Start2023 | PhaseNot applicable | ConditionsStroke, Delirium, surgery and intensive care, Cardiovascular disease | Participants842 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT05980195 | Start2024 | PhaseNot applicable | ConditionsCardiovascular disease | Participants90 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05848934 | Start2023 | PhaseObservational | ConditionsCardiovascular disease | Participants100 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05848921 | Start2023 | PhaseObservational | ConditionsCardiovascular disease | Participants100 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05647473 | Start2024 | PhasePhase 2 | ConditionsDementia and Alzheimer's, Cardiovascular disease | Participants66 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05595577 | Start2023 | PhaseNot applicable | ConditionsCancer, Cardiovascular disease | Participants105 | Lead sponsorOther | StatusActive, not recruiting | Library tests named
|
| NCT05539261 | Start2022 | PhaseObservational | ConditionsCardiovascular disease | Participants30 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05317104 | Start2022 | PhaseNot applicable | ConditionsCardiovascular disease | Participants26 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT05249296 | Start2020 | PhaseNot applicable | ConditionsCardiovascular disease | Participants50 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
| NCT05243784 | Start2022 | PhaseNot applicable | ConditionsAging, frailty and exercise, Obesity and diabetes, Cardiovascular disease | Participants62 | Lead sponsorOther | StatusCompleted | Library tests named
|
| NCT05223426 | Start2023 | PhaseNot applicable | ConditionsCardiovascular disease | Participants54 | Lead sponsorOther | StatusStatus unknown | Library tests named
|
Questions, answered from the data
How many cardiovascular trials use the Digit Span Test?
59 registered cardiovascular disease studies on ClinicalTrials.gov name it in an outcome measure, 20 of them in a primary outcome: 9% of the condition's 682 studies with a cognitive outcome, against 10% of all of them. It is the 5th most named test in cardiovascular trials.
Which tests do cardiovascular trials use with the Digit Span Test?
The Trail Making Test (32 studies), Verbal Learning (29 studies) and Verbal Fluency (22 studies).
When do cardiovascular trials measure the Digit Span Test?
Half of the primary outcomes that name the Digit Span Test are measured within 15 weeks of the start, and the middle half from 4 weeks to 6 months. 18 primary outcomes give a duration.
How many completed cardiovascular trials that use the Digit Span Test have reported results?
15 of the 28 completed studies that name it, 54%, have reported results: 12 posted them on ClinicalTrials.gov, 11 have a results paper linked to the registry record, and 8 did both. The other 13 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.
How the studies are counted
For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.
The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.
A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.
A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.
Run the Digit Span Test in your trial
Choose tests with a record in registered trials, and run them in a browser at every site, on the same version each visit.