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  5. /Serial Reaction Time

Clinical trials data

Serial Reaction Time in clinical trials: 27 registered studies

Every registered study on ClinicalTrials.gov that names Serial Reaction Time in an outcome measure: the conditions it is used in, how often it is a primary outcome, the tests it is named with, and how large the studies are.

Registered studies name it in an outcome measure
27
Name it in a primary outcome, 48%
13 of 27
Against similar tests
Of studies started 2021 to 2025 name it, against 0.2% in 2016 to 2020
0.1%
By year
Median participants per study
45
By phase
Try Serial Reaction Time

The conditions it is used in

Each study counted once in each condition group it falls in.
  1. Healthy volunteers6 studies, 5 as a primary outcome

  2. Aging, frailty and exercise6 studies, 3 as a primary outcome

  3. Parkinson's disease5 studies, 3 as a primary outcome

  4. Stroke4 studies, 1 as a primary outcome

  5. Brain injury and concussion3 studies, 1 as a primary outcome

  6. Depression and bipolar disorder2 studies, 0 as a primary outcome

  7. Cancer2 studies, 0 as a primary outcome

  8. Dementia and Alzheimer's1 study, 0 as a primary outcome

  9. ADHD1 study, 1 as a primary outcome

  10. Epilepsy1 study, 1 as a primary outcome

  11. Other conditions3 studies, 1 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

How often it is a primary outcome

Serial Reaction Time is a primary outcome in 48% of its studies. Across the 11 processing speed tests with a page here, the median is 42%.
  1. Motor Sequence Task53% of 30 studies

  2. Serial Reaction Time48% of 27 studies

  3. Arithmetic Fluency Task47% of 101 studies

  4. Mirror Tracing Task43% of 23 studies

  5. Symbol Scan Task42% of 129 studies

  6. Paced Visual Serial Addition Test42% of 337 studies

  7. Simple Reaction Time40% of 210 studies

  8. Finger Tapping Task38% of 144 studies

  9. Pattern and Letter Comparison35% of 147 studies

  10. Symbol Coding31% of 1,457 studies

  11. Trail Making Test31% of 2,293 studies

Studies by start year

0.1% of the registered studies that started in 2021 to 2025 name it, against 0.2% of those that started in 2016 to 2020. 2026 is partly planned starts.
02000: 0 studies, 0 with a test as a primary outcome20002001: 0 studies, 0 with a test as a primary outcome2002: 0 studies, 0 with a test as a primary outcome2003: 0 studies, 0 with a test as a primary outcome2004: 0 studies, 0 with a test as a primary outcome2005: 0 studies, 0 with a test as a primary outcome20052006: 0 studies, 0 with a test as a primary outcome2007: 0 studies, 0 with a test as a primary outcome2008: 0 studies, 0 with a test as a primary outcome2009: 0 studies, 0 with a test as a primary outcome2010: 0 studies, 0 with a test as a primary outcome20102011: 0 studies, 0 with a test as a primary outcome2012: 1 studies, 0 with a test as a primary outcome2013: 0 studies, 0 with a test as a primary outcome2014: 0 studies, 0 with a test as a primary outcome2015: 4 studies, 2 with a test as a primary outcome20152016: 0 studies, 0 with a test as a primary outcome2017: 1 studies, 0 with a test as a primary outcome2018: 1 studies, 0 with a test as a primary outcome2019: 4 studies, 3 with a test as a primary outcome2020: 5 studies, 2 with a test as a primary outcome20202021: 1 studies, 1 with a test as a primary outcome2022: 2 studies, 1 with a test as a primary outcome2023: 2 studies, 1 with a test as a primary outcome2024: 3 studies, 2 with a test as a primary outcome2025: 1 studies, 0 with a test as a primary outcome20252026: 2 studies, 1 with a test as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Show as a table
Registered studies by start year
Start yearStudiesA test as a primary outcome
200000
200100
200200
200300
200400
200500
200600
200700
200800
200900
201000
201100
201210
201300
201400
201542
201600
201710
201810
201943
202052
202111
202221
202321
202432
202510
202621

Phases and study sizes

By phase

  • Phase 21 studies, 0 as a primary outcome
  • Not applicable22 studies, 11 as a primary outcome
  • Observational4 studies, 2 as a primary outcome

Participants per study

102050100
  • Not applicable45 median, 31 to 63
Participants per study. The bar spans the middle half of the studies in each phase, the mark is the median, and the axis is logarithmic. Phases with fewer than 10 studies that give a size are left out.
Show as a table
Participants per study that names Serial Reaction Time, by phase
PhaseStudies with a sizeMedianMiddle half
Not applicable224531 to 63

When trials measure it

Half of the primary outcomes that name Serial Reaction Time are measured within 6 days of the start, and the middle half from the first day to 5 weeks. 10 primary outcomes give a duration.

Latest time point of each outcome

  • Within a day9 outcomes, 4 as a primary outcome
  • Up to 4 weeks8 outcomes, 3 as a primary outcome
  • 1 to 3 months5 outcomes, 3 as a primary outcome
  • 6 to 12 months1 outcomes, 0 as a primary outcome
  • 1 to 2 years1 outcomes, 0 as a primary outcome
  • No duration given3 outcomes, 3 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

24 of the 27 outcome measures give a duration. A single visit counts as within a day.

Status, results, interventions and countries

Status

  • Recruiting5 studies, 1 as a primary outcome
  • Active, not recruiting1 studies, 1 as a primary outcome
  • Completed17 studies, 10 as a primary outcome
  • Stopped early1 studies, 0 as a primary outcome
  • Status unknown3 studies, 1 as a primary outcome

What they test

  • Behavioral9 studies, 4 as a primary outcome
  • Drug1 studies, 0 as a primary outcome
  • Device10 studies, 6 as a primary outcome
  • Procedure1 studies, 0 as a primary outcome
  • Other5 studies, 3 as a primary outcome
  • None given3 studies, 1 as a primary outcome

Intervention types as registered. A study can list several; observational studies often list none.

Where their sites are

  • United States7 studies, 3 as a primary outcome
  • France4 studies, 0 as a primary outcome
  • Belgium2 studies, 2 as a primary outcome
  • Brazil2 studies, 2 as a primary outcome
  • Canada2 studies, 0 as a primary outcome
  • Germany2 studies, 1 as a primary outcome
  • Taiwan2 studies, 1 as a primary outcome
  • Netherlands1 studies, 0 as a primary outcome
  • Singapore1 studies, 1 as a primary outcome
  • Sweden1 studies, 0 as a primary outcome
  • Thailand1 studies, 1 as a primary outcome
  • Türkiye1 studies, 1 as a primary outcome

13 countries in all. A study with sites in several counts in each; 0 list no site.

Reported results

Completed studies with results posted on ClinicalTrials.gov, a results paper the registry links to the study, or both.

Completed studies that name Serial Reaction Time: 10 of 17, 59%

Every completed study with a cognitive outcome: 3,626 of 7,953, 46%

Completed studies that name Serial Reaction Time and every completed study, by how they reported results
ResultsCompleted studies that name Serial Reaction TimeEvery completed study
Results on ClinicalTrials.gov and a paper1, 6%776, 10%
Results on ClinicalTrials.gov only3, 18%1,139, 14%
A results paper only6, 35%1,711, 22%
Neither7, 41%4,327, 54%

Tests named in the same studies

The library tests that studies naming Serial Reaction Time name most often beside it.
  1. 1

    Trail Making Test5 studies, 1 as a primary outcome

  2. 2

    Digit Span Test4 studies, 1 as a primary outcome

  3. 3

    Stroop Color-Word Test4 studies, 1 as a primary outcome

  4. 4

    Go/No-Go Task3 studies, 1 as a primary outcome

  5. 5

    N-Back Task3 studies, 1 as a primary outcome

  6. 6

    Verbal Fluency3 studies, 0 as a primary outcome

  7. 7

    Motor Sequence Task2 studies, 1 as a primary outcome

  8. 8

    Paired Associate Learning2 studies, 1 as a primary outcome

  9. 9

    Stop-Signal Task2 studies, 1 as a primary outcome

  10. 10

    Task Switching Test2 studies, 0 as a primary outcome

A test as a primary outcomeOnly in secondary or other outcomes

Compared over time

Studies per start year for Serial Reaction Time and the tests named with it most. Add or remove tests to compare.
Serial Reaction Time27 studies, 2000 to 2026
01252502000201020202026
Trail Making Test2,281 studies, 2000 to 2026
01252502000201020202026
Digit Span Test1,619 studies, 2000 to 2026
01252502000201020202026
Stroop Color-Word Test1,922 studies, 2000 to 2026
01252502000201020202026

The panel's testThe other tests chosenEvery panel has the same scale. 2026 is partly planned starts.

Show as a table
Registered studies per start year that name each test
Start yearSerial Reaction TimeTrail Making TestDigit Span TestStroop Color-Word Test
20000233
20010023
20020315
20030842
200401048
2005014711
200601446
20070211413
20080171915
20090292216
20100323729
20110472631
20121443632
20130604442
20140664964
20154857967
201601036985
201711228279
2018111785103
20194155110119
202051229099
20211172122151
20222188121168
20232228164198
20243211141182
20251210147198
20262201137193

Explore the 27 studies

Filter by condition, phase, sponsor, status, country, intervention, outcome list, size and start year. Each study links to its record on ClinicalTrials.gov.
TestSerial Reaction Time

27 studies match. 13 name Serial Reaction Time in a primary outcome. Median size 45 participants. Median time to the primary outcome: 6 days.

Loading 27 studies; the filters turn on when they arrive.

By start year
02462000: 0 studies, 0 naming Serial Reaction Time in a primary outcome20002001: 0 studies, 0 naming Serial Reaction Time in a primary outcome2002: 0 studies, 0 naming Serial Reaction Time in a primary outcome2003: 0 studies, 0 naming Serial Reaction Time in a primary outcome2004: 0 studies, 0 naming Serial Reaction Time in a primary outcome2005: 0 studies, 0 naming Serial Reaction Time in a primary outcome20052006: 0 studies, 0 naming Serial Reaction Time in a primary outcome2007: 0 studies, 0 naming Serial Reaction Time in a primary outcome2008: 0 studies, 0 naming Serial Reaction Time in a primary outcome2009: 0 studies, 0 naming Serial Reaction Time in a primary outcome2010: 0 studies, 0 naming Serial Reaction Time in a primary outcome20102011: 0 studies, 0 naming Serial Reaction Time in a primary outcome2012: 1 studies, 0 naming Serial Reaction Time in a primary outcome2013: 0 studies, 0 naming Serial Reaction Time in a primary outcome2014: 0 studies, 0 naming Serial Reaction Time in a primary outcome2015: 4 studies, 2 naming Serial Reaction Time in a primary outcome20152016: 0 studies, 0 naming Serial Reaction Time in a primary outcome2017: 1 studies, 0 naming Serial Reaction Time in a primary outcome2018: 1 studies, 0 naming Serial Reaction Time in a primary outcome2019: 4 studies, 3 naming Serial Reaction Time in a primary outcome2020: 5 studies, 2 naming Serial Reaction Time in a primary outcome20202021: 1 studies, 1 naming Serial Reaction Time in a primary outcome2022: 2 studies, 1 naming Serial Reaction Time in a primary outcome2023: 2 studies, 1 naming Serial Reaction Time in a primary outcome2024: 3 studies, 2 naming Serial Reaction Time in a primary outcome2025: 1 studies, 0 naming Serial Reaction Time in a primary outcome20252026: 2 studies, 1 naming Serial Reaction Time in a primary outcome

2026 is partly planned starts.

Show as a table
Matching studies by start year
Start yearStudiesAs a primary outcome
200000
200100
200200
200300
200400
200500
200600
200700
200800
200900
201000
201100
201210
201300
201400
201542
201600
201710
201810
201943
202052
202111
202221
202321
202432
202510
202621

Library tests named most

  • Serial Reaction Time27 studies, 13 as a primary outcome
  • Trail Making Test5 studies, 1 as a primary outcome
  • Digit Span Test4 studies, 1 as a primary outcome
  • Stroop Color-Word Test4 studies, 1 as a primary outcome
  • Go/No-Go Task3 studies, 1 as a primary outcome
  • N-Back Task3 studies, 1 as a primary outcome
  • Verbal Fluency3 studies, 0 as a primary outcome
  • Motor Sequence Task2 studies, 1 as a primary outcome
  • Paired Associate Learning2 studies, 1 as a primary outcome
  • Stop-Signal Task2 studies, 1 as a primary outcome

Conditions

Phases

Participants

Lead sponsor: other 27. Interventional 23, observational 4.

As a primary outcomeSecondary or other outcomeSerial Reaction Time

The studies, newest registration first

Each number opens the study's record on ClinicalTrials.gov.

Registered studies that match the filters, newest registration first, with the library tests each one names and the outcome list that names them.
StudyStartPhaseConditionsParticipantsLead sponsorStatusLibrary tests named, with the latest time point
NCT07345481Start2026PhaseObservationalConditionsStroke, Brain injury and concussionParticipants40Lead sponsorOtherStatusRecruitingLibrary tests named
  • Trail Making TestSecondarysame day
  • Stroop Color-Word TestSecondarysame day
  • Verbal LearningSecondarysame day
  • Digit Span TestSecondarysame day
  • Task Switching TestSecondarysame day
  • Serial Reaction TimeSecondarysame day
NCT06950060Start2026PhaseNot applicableConditionsStroke, Aging, frailty and exerciseParticipants48Lead sponsorOtherStatusActive, not recruitingLibrary tests named
  • Verbal FluencySecondary5 days
  • Motor Sequence TaskPrimary5 days
  • Serial Reaction TimePrimary5 days
NCT06599931Start2024PhaseNot applicableConditionsStroke, Healthy volunteersParticipants45Lead sponsorOtherStatusRecruitingLibrary tests named
  • Serial Reaction TimeSecondarysame day
  • Visuomotor Adaptation TaskSecondarysame day
NCT06599879Start2025PhaseNot applicableConditionsCancerParticipants130Lead sponsorOtherStatusRecruitingLibrary tests named
  • Serial Reaction TimeSecondary2 years
NCT06491160Start2024PhaseObservationalConditionsADHDParticipants20Lead sponsorOtherStatusCompletedLibrary tests named
  • Stop-Signal TaskPrimarysame day
  • Serial Reaction TimePrimarysame day
NCT06340893Start2024PhaseNot applicableConditionsOther conditionsParticipants40Lead sponsorOtherStatusRecruitingLibrary tests named
  • Serial Reaction TimePrimary12 weeks
  • Novel Word Learning TaskPrimary12 weeks
NCT06038643Start2023PhaseNot applicableConditionsDementia and Alzheimer's, Aging, frailty and exerciseParticipants76Lead sponsorOtherStatusCompleted

Results

Library tests named
  • Digit Span TestSecondary4 weeks
  • Go/No-Go TaskSecondary4 weeks
  • Continuous Performance TestSecondary4 weeks
  • Matrix ReasoningSecondary4 weeks
  • Choice Reaction TimeSecondary4 weeks
  • AX Continuous Performance TestWording unclear
  • Serial Reaction TimeSecondary4 weeks
  • Gradual-Onset Continuous Performance TaskSecondary4 weeks
NCT05929014Start2023PhaseNot applicableConditionsHealthy volunteersParticipants20Lead sponsorOtherStatusCompleted

Paper

Library tests named
  • Serial Reaction TimePrimarysame day
NCT05511259Start2022PhaseNot applicableConditionsAging, frailty and exerciseParticipants93Lead sponsorOtherStatusCompletedLibrary tests named
  • Trail Making TestPrimary13 weeks
  • Stroop Color-Word TestPrimary13 weeks
  • Digit Span TestPrimary13 weeks
  • N-Back TaskPrimary13 weeks
  • Go/No-Go TaskPrimary13 weeks
  • Serial Reaction TimePrimary13 weeks
NCT05159609Start2020PhaseNot applicableConditionsEpilepsyParticipants17Lead sponsorOtherStatusCompletedLibrary tests named
  • Paired Associate LearningPrimary
  • Serial Reaction TimePrimary
NCT04932057Start2021PhaseNot applicableConditionsHealthy volunteersParticipants60Lead sponsorOtherStatusCompleted

Paper

Library tests named
  • Cancellation TestPrimary
  • Serial Reaction TimePrimary
NCT04890639Start2022PhaseNot applicableConditionsBrain injury and concussionParticipants12Lead sponsorOtherStatusCompleted

Results

Library tests named
  • Trail Making TestSecondary2 weeks
  • Verbal LearningSecondary2 weeks
  • Verbal FluencySecondary2 weeks
  • Finger Tapping TaskSecondary2 weeks
  • Serial Reaction TimeSecondary2 weeks
NCT04708691Start2020PhaseNot applicableConditionsDepression and bipolar disorderParticipants40Lead sponsorOtherStatusStatus unknownLibrary tests named
  • N-Back TaskSecondary4 weeks
  • Serial Reaction TimeSecondary4 weeks
NCT04611009Start2020PhasePhase 2ConditionsOther conditionsParticipants54Lead sponsorOtherStatusRecruitingLibrary tests named
  • Motor Sequence TaskSecondary12 months
  • Serial Reaction TimeSecondary12 months
NCT04606979Start2020PhaseNot applicableConditionsParkinson's disease, Healthy volunteersParticipants30Lead sponsorOtherStatusCompletedLibrary tests named
  • Serial Reaction TimePrimary1 week
NCT04324450Start2020PhaseNot applicableConditionsCancerParticipants60Lead sponsorOtherStatusCompleted

Paper 1Paper 2Paper 3Paper 4

Library tests named
  • Stroop Color-Word TestSecondary2 days
  • Card Sorting Test (Berg)Secondary2 days
  • Vocabulary TestSecondary2 days
  • Serial Reaction TimeSecondary2 days
NCT04189887Start2019PhaseObservationalConditionsParkinson's diseaseParticipants60Lead sponsorOtherStatusCompleted

Paper

Library tests named
  • Trail Making TestOther outcomesame day
  • Stroop Color-Word TestOther outcomesame day
  • Task Switching TestOther outcomesame day
  • Serial Reaction TimePrimarysame day
NCT04144283Start2019PhaseNot applicableConditionsParkinson's disease, Aging, frailty and exerciseParticipants80Lead sponsorOtherStatusStatus unknown

Paper

Library tests named
  • Serial Reaction TimePrimary
NCT04138953Start2019PhaseNot applicableConditionsBrain injury and concussionParticipants64Lead sponsorOtherStatusCompleted

Results

Library tests named
  • Serial Reaction TimePrimarysame day
NCT03970239Start2019PhaseNot applicableConditionsParkinson's diseaseParticipants45Lead sponsorOtherStatusStatus unknownLibrary tests named
  • Stop-Signal TaskSecondary3 days
  • Serial Reaction TimeSecondary3 days
NCT03453983Start2018PhaseNot applicableConditionsOther conditionsParticipants35Lead sponsorOtherStatusCompleted

Paper

Library tests named
  • Serial Reaction TimeSecondarysame day
NCT03213873Start2017PhaseNot applicableConditionsParkinson's disease, Aging, frailty and exerciseParticipants95Lead sponsorOtherStatusCompleted

ResultsPaper 1Paper 2Paper 3Paper 4Paper 5Paper 6Paper 7

Library tests named
  • Verbal FluencySecondary10 weeks
  • Digit Span TestSecondary10 weeks
  • Serial Reaction TimeSecondary10 weeks
NCT02559518Start2015PhaseNot applicableConditionsHealthy volunteersParticipants18Lead sponsorOtherStatusCompletedLibrary tests named
  • Serial Reaction TimePrimary6 weeks
NCT02557841Start2015PhaseNot applicableConditionsHealthy volunteersParticipants12Lead sponsorOtherStatusCompletedLibrary tests named
  • Serial Reaction TimePrimary1 week
NCT02465034Start2015PhaseNot applicableConditionsStrokeParticipants45Lead sponsorOtherStatusStopped early

Results

Library tests named
  • Serial Reaction TimeSecondarysame day

Page 1 of 2

Questions, answered from the data

How many clinical trials use Serial Reaction Time?

27 registered studies on ClinicalTrials.gov name it in an outcome measure, 13 of them in a primary outcome.

In which conditions do trials use Serial Reaction Time?

Most often in healthy volunteers (6), aging, frailty and exercise (6) and Parkinson's disease (5).

Do new trials use Serial Reaction Time more or less?

0.1% of the studies that started in 2021 to 2025 name it, against 0.2% of those that started in 2016 to 2020: a share 48% smaller.

Which tests do trials use with Serial Reaction Time?

The Trail Making Test (5 studies), the Digit Span Test (4 studies) and the Stroop Color-Word Test (4 studies).

When do trials measure Serial Reaction Time?

Half of the primary outcomes that name Serial Reaction Time are measured within 6 days of the start, and the middle half from the first day to 5 weeks. 10 primary outcomes give a duration.

How many completed trials that use Serial Reaction Time have reported results?

10 of the 17 completed studies that name it, 59%, have reported results: 4 posted them on ClinicalTrials.gov, 7 have a results paper linked to the registry record, and 1 did both. The other 7 show neither. Of all completed studies with a cognitive outcome, 46% have reported results.

More on tests in clinical trials

  • Serial Reaction Time: what it measures, its scores, and a version to try
  • All 101 tests in clinical trials
  • Cognitive tests by condition
  • Every registered study, by test, condition, phase and year

How the studies are counted

For each test family, the census runs ClinicalTrials.gov's own outcome search for the family's names and reads every study first posted by the day the family was counted. These studies were read on 10 November 2026. A study counts once on a page, however many tests it names. Counts for a test cover every version of the task under any of its names, so a page can count studies that used a commercial version.

The census adds two things to each record and changes nothing in it: which outcome list names the test (primary, then secondary, then other), and the condition groups, matched on the study's condition names and MeSH terms. A study can fall in several groups; one whose only condition is cognitive impairment or decline falls in “Cognitive impairment and decline”. Studies that name only instruments outside the library count in every total and share but are not listed.

A second read on 10 November 2026 added each study's overall status, whether results are posted, its intervention types, the countries of its sites and the time frame of the outcome that names each test. A time frame counts by the latest time point it names: “Baseline, 12 and 24 weeks” is 24 weeks, a single visit is within a day, and one that names no duration, such as “end of treatment”, is left out of the timings.

A third read on 10 November 2026 added the papers the registry links to each study: those its sponsor lists as reporting results, and those PubMed links to it through the study's NCT number. A study has a results paper when one of them came out in or after the month of its primary completion and PubMed does not class it as a protocol, review or comment. A paper that never gives the NCT number is not linked, so some studies counted as reporting neither did publish.

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine, which does not endorse these pages. Every study line is in the data release 2.1.0, and the explorer's own file is clinical-trials-studies.json.

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